ID A0A182FFY7_ANOAL Unreviewed; 1313 AA.
AC A0A182FFY7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=receptor protein serine/threonine kinase {ECO:0000256|ARBA:ARBA00012401};
DE EC=2.7.11.30 {ECO:0000256|ARBA:ARBA00012401};
OS Anopheles albimanus (New world malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7167 {ECO:0000313|EnsemblMetazoa:AALB005429-PA, ECO:0000313|Proteomes:UP000069272};
RN [1] {ECO:0000313|EnsemblMetazoa:AALB005429-PA}
RP IDENTIFICATION.
RC STRAIN=STECLA/ALBI9_A {ECO:0000313|EnsemblMetazoa:AALB005429-PA};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the MT-A70-like family. {ECO:0000256|PROSITE-
CC ProRule:PRU00489}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. TGFB receptor subfamily.
CC {ECO:0000256|ARBA:ARBA00009605}.
CC -!- SIMILARITY: Belongs to the scoloptoxin-05 family.
CC {ECO:0000256|ARBA:ARBA00025739}.
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DR STRING; 7167.A0A182FFY7; -.
DR EnsemblMetazoa; AALB005429-RA; AALB005429-PA; AALB005429.
DR VEuPathDB; VectorBase:AALB005429; -.
DR VEuPathDB; VectorBase:AALB20_026159; -.
DR VEuPathDB; VectorBase:AALB20_026645; -.
DR Proteomes; UP000069272; Chromosome 3L.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016422; F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; IEA:InterPro.
DR GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR Gene3D; 2.10.60.10; CD59; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000472; Activin_recp.
DR InterPro; IPR003605; GS_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR025848; MT-A70.
DR InterPro; IPR007757; MT-A70-like.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR000333; TGFB_receptor.
DR PANTHER; PTHR23255:SF72; RECEPTOR PROTEIN SERINE_THREONINE KINASE; 1.
DR PANTHER; PTHR23255; TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II; 1.
DR Pfam; PF01064; Activin_recp; 1.
DR Pfam; PF05063; MT-A70; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF08515; TGF_beta_GS; 1.
DR SMART; SM00467; GS; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF57302; Snake toxin-like; 1.
DR PROSITE; PS51256; GS; 1.
DR PROSITE; PS51143; MT_A70; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS51563; SAM_MTA70L_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022527}.
FT BINDING 258
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1313 AA; 143394 MW; B8725459DE2DD0E7 CRC64;
MEIELAHANR NVPAPNSIIP HQRYKCLSCE PPDCTTVHQH HCQNAIQCWK SRTRDQEGNE
NVQRGCTTEH DQLPLYCNQN QKSKNGNTNG SGGGGGPKKR HVNSSGTYNI ECCTGDYCND
GDFPELPSPN VPETEEQDPF AGRVAIAVLV PFGSILAITV AAVFCLRRAH AKRVNASRTK
YDQETYYTND DVLRATSAGD STLREYLQHS VTSGSGSGLP LLIQRTLAKQ VSLCECIGRG
RYGEVWRGIW HGESVAVKIF FSRDEDSWKR ETEIYGTVLL RHENILGYVG SDMTSRNSCT
QLWLITHYFP QGSLYDFLNR TAITTHQMIT ICLSIANGLV HLHTEIFGTE GKPAIAHRDL
KTKNILIRAN GTCVIADFGL AVMHSQTTNK IDIGSTARVG TKRYMAPEVL DESINMECFD
ALRKADIYAI GLIFWEVCRR TISCGIAEEY KVPYYDYVSS DPSFEEMRKV VCVDNYRPSV
QNRWTSDQIL AGMSKLMREC WHTNSNVRLP ALRIKKTLLK LASSDETLKI NPDGDFIRIP
RTCAVATVVF VVLLLLPVCW NMSSWEEIQA VKVKRNSLRE KLEKRKKERQ DLLLGNSSPA
GPGGSLIKLE SGVSLGDDKG NKLLLPTIKL DQGAGSAGNT RVCYIDAEVE KCLVKVLADQ
SLILPTNSTQ ITERVESMMQ KTAPLRDSVA YYLHKLASQN LINIKEVSIG GTVGYEVISA
EHTRIQALHD DLGLSHIPMA ALADRESVGK RKALDGDEDE LLLLLKGSST SKVARGAAGL
KEEGYRGKGA GAADSSSSSS SSSTAASSAA ASVQASDIMS LLSLPSTREK QHKKVGEEIL
ELLSKPTAKE RSLAEKFKSQ GGAQVMEFCP HGTRIECMRS LDAANEAAAA AAAAAAKERS
DSNDNRDGGD DRETGTKPDS NSDSQSERGS RSKNGADVGD VKKEPAADVG MDAVSPGSNS
NSSSSGAAPD SKQQQPPPAV SKYRCNKLHF KKIIQNHTDE TLGDCSFLNT CFHMDTCKYV
HYQVDTYQTV GQPGPGGALA GALAKPDGKT KAKVKPKALD DALAGGTGAV GGGGAAAAAA
TGAGLGAKRS PITNEPCATL YPPQWIQCDL RFLDMTVLGK FAVVMADPPW DIHMELPYGT
MSDDEMRQLG VPALQDDGLI FLWVTGRAME LGRECLKLWG YERVDELIWV KTNQLQRIIR
TGRTGHWLNH GKEHCLVGMK GNPPNLNRGL DCDVIVAEVR ATSHKPDEIY GIIERLSPGT
RKIELFGRPH NVQPNWITLG NQLDGIQIVD PELISSFRNR YPDGNCMTPG KNP
//
