ID A0A182FJ51_ANOAL Unreviewed; 1559 AA.
AC A0A182FJ51;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AALB006546-PA};
OS Anopheles albimanus (New world malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7167 {ECO:0000313|EnsemblMetazoa:AALB006546-PA, ECO:0000313|Proteomes:UP000069272};
RN [1] {ECO:0000313|EnsemblMetazoa:AALB006546-PA}
RP IDENTIFICATION.
RC STRAIN=STECLA/ALBI9_A {ECO:0000313|EnsemblMetazoa:AALB006546-PA};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR STRING; 7167.A0A182FJ51; -.
DR EnsemblMetazoa; AALB006546-RA; AALB006546-PA; AALB006546.
DR VEuPathDB; VectorBase:AALB006546; -.
DR VEuPathDB; VectorBase:AALB20_036335; -.
DR Proteomes; UP000069272; Chromosome X.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:UniProt.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 2.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF133; INTEGRIN ALPHA-PS2; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 2.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 6.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 6.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1504..1527
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT DOMAIN 477..644
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 645..784
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 795..939
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT DOMAIN 1375..1495
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1559 AA; 168438 MW; 9357DA5D242B6EFB CRC64;
MGIGRTPDGR RRSSTVMGAA TVNAALLVLL VCCFCRTAAF NLDTINYILQ EGDPNSMFGF
SVALHREQNK SWVIVGAPTA NTTQPDVIEG GAVYRCDIYD DSRCSLVPFD MEGNRENDQK
EQIDTKSNQW FGATVVSAGI DGPLVACAPR YVFHQLQPRK AERVEPVGTC HIAKNNMREF
QELSPCRTSY WGYHRQGSCQ AGFSAALTKD GTRVFIGAPG SYYWQGQIYS YSLNNPKDKV
YKTLEDKKDE DDSYLGYSAT TGDFNGDGTQ GVAVGKPRGA GLLGKVLIYA WNMTNQQNIT
GEQIGAYFGY SLAAVDVDGD GLDDLIIGAP MHTEPNNEGK YETGRVYIIY HGGGDGTDQR
RFGELETRDG STSRGRFGLS LCSLADINLD GYGDFAVGAP YDGPTGRGAV YVFYGARTGT
LAKASQVLQA EELAWGVPGR LTTFGFSLAG GIDLDGNQYP DLAVGAYDTD KVLVFRSRPV
ATMEASTLFE TENKLISLDE RNCTLERSQK QVACTVVNSC LKYGGINVPP VLDIEIGWTL
DARSPRSPRL FFLNDEGRNV LNQSMRLYRG KLECRSERVY VGESVRDKIT PLEVEMRYGL
RESRGGGGAL AGQHRQRRPR LNVEPVLDAN RGTVQRDSIN IQKNCGPDNV CIPDLRLDIK
SVDEYLLGSN NLLTIEVLIT NRGEDAFEAG FYMLVPAGLD FRRVDRLGEV RDVPVLCTAP
SHANNGTLRC DIGNPLASGK VVNFKVILAP SFAVGMAPSY DFYLEANSTN PELPGAALQD
NVVRKSIGIS IRTNLALSGV SLPDEFLYNY TEYRPLAEAT SERDLGPQIV HIYEIRNEGP
STIDEAEFYV LWPTETIDQV PLMYLLNQPE THGNIQCQPT EYANSRHLAL DTVLARKSFL
DKVGVSTGTS YSSVAGGTGR LTATVTPSIS FSSSSSGAAA GGGSRVQATE STSNRGRYAG
ESSERRDGSY ERRQHSSSSS SSSTVTSAGG GASGASVSTS AERRQESSSR QQGQSYGGQG
QQQQEVSGGG TGSSSTFYTY RNRTVHRTED GTGSRVSYES NEYRKSGSGA GAGIVGPNAL
GVGIGKEGSS SSSSSSTTTS SSSSSSSSSS SSKNYDQQYG GSSGRFVGTS QTQGSSLSVA
SGSSSASSGS GRRRMMSQQD GDSQYGHGSH RNGVLVTDFL SLDGGAHRSG SSHGGEGHGA
AGTLDSMANR FRTDYSSTAS TGSSSYGGRT GSSIASSSSS SSSQQQQQQQ QQQQHTERTE
AGTGSYHHTA GGGYRQQHYQ GMTSNGTHMI YTSGSTYGGL GDGEDEDSYD DTLYDRSEEA
YEEATGGTDV PPRTAHDYAL GTHRVHQQQQ QYAGQHYHTG TTIPHLSKQH LNEGHETVDQ
KFRYYQRFDQ RTRERRQAPA DTDDNGPDRA LEEALTCHTA RCAMLRCVAG PIGNKDVAFI
ALRTRAVAHT LHQLSAATPL HFSTKIVARV TKLPYIGQPK EKPIKTHEIR VLAVPEPIPK
PDVVPLWIVV LAACAGTLIL LLLIYLLSKC GFFERNRPTD SSERQPLNRN GNYPGDEHL
//
