ID   A0A182FLN5_ANOAL        Unreviewed;       804 AA.
AC   A0A182FLN5;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=Origin recognition complex subunit 1 {ECO:0000256|ARBA:ARBA00019081, ECO:0000256|RuleBase:RU365058};
OS   Anopheles albimanus (New world malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7167 {ECO:0000313|EnsemblMetazoa:AALB007444-PA, ECO:0000313|Proteomes:UP000069272};
RN   [1] {ECO:0000313|Proteomes:UP000069272}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=STECLA/ALBI9_A {ECO:0000313|Proteomes:UP000069272};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles albimanus ALBI9_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AALB007444-PA}
RP   IDENTIFICATION.
RC   STRAIN=STECLA/ALBI9_A {ECO:0000313|EnsemblMetazoa:AALB007444-PA};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC       origins of replication. DNA-binding is ATP-dependent, however specific
CC       DNA sequences that define origins of replication have not been
CC       identified so far. ORC is required to assemble the pre-replication
CC       complex necessary to initiate DNA replication.
CC       {ECO:0000256|RuleBase:RU365058}.
CC   -!- SUBUNIT: ORC is composed of six subunits.
CC       {ECO:0000256|RuleBase:RU365058}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU365058}.
CC   -!- SIMILARITY: Belongs to the ORC1 family. {ECO:0000256|ARBA:ARBA00008398,
CC       ECO:0000256|RuleBase:RU365058}.
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DR   AlphaFoldDB; A0A182FLN5; -.
DR   STRING; 7167.A0A182FLN5; -.
DR   EnsemblMetazoa; AALB007444-RA; AALB007444-PA; AALB007444.
DR   VEuPathDB; VectorBase:AALB007444; -.
DR   VEuPathDB; VectorBase:AALB20_032319; -.
DR   Proteomes; UP000069272; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 2.30.30.490; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041083; AAA_lid_10.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR001025; BAH_dom.
DR   InterPro; IPR043151; BAH_sf.
DR   InterPro; IPR015163; Cdc6_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR   PANTHER; PTHR10763:SF23; ORIGIN RECOGNITION COMPLEX SUBUNIT 1; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF17872; AAA_lid_10; 1.
DR   Pfam; PF09079; Cdc6_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00439; BAH; 1.
DR   SMART; SM01074; Cdc6_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51038; BAH; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU365058};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|RuleBase:RU365058};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU365058};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU365058};
KW   Nucleus {ECO:0000256|RuleBase:RU365058}.
SQ   SEQUENCE   804 AA;  90528 MW;  907E640102819F4B CRC64;
     MKVVAPKPVK WVDDVIGLED TDLRRRDVAF HSKCMFGTLT IEVGCYVLVS NMNATNPDSI
     EGCDVAQILR MYELVGYDRN YNKDPFRATV RWFSRPSALP KSILSDKIVS FDAHEVVEDP
     RFNPEISIET IYGLCCVHYA TFPEEKLPNE YSQIKTRYLV RYKLMKSSGR KWVLQPLEPV
     PTRTHVSHGK SVKEQTLPAN TPKLKLKRTK SIENCTATSI GLEKKIHEDH WKVQLVDCMA
     DLTNALSDVE ISKKRKARIS HVSQIAKTEK GIANNPKSHL DPSLRVNYDD GNEEKKNYSI
     VKSKSNTADM KIKIRISDNQ TEIDLGTSSN IPRKRVLNGT TPLNNQSSPP KTRKKSASFD
     HICRKNMVKL VNNQQLVEDD ISQIIVDDRF EQRKEYESPK HEGDGTTLTK HIRIGSIKPT
     DFKSTPRGCV SNDLSIVREK LHVAAIPSSL PCREKEYDIL FSFLENKICD GSGGCMYVSG
     VPGTGKTATT SAVISSLKML SEAEEIPKFQ LVDINGMRLT EPRQAYVQIY RQLTGKTLAW
     EQAYTLLNKR FTTKGPRRIT MVLVIDELDI LCNRRQDVVY NLLNWPTLPE AQLIVVTIAN
     TMDLPERVLM GKISSRLGLT RLTFQPYNFR QLQEIVMARL AGTNTFNSDA VQLVSRKVAA
     VSGDARRALD ICRRATELCD SSSSVVSMAK VQIVLAEMIT SPQVKTIRSC SRIEQMFLHA
     VMIELTRIGI DECCFLGVYA QLETLCTFSG ISVPNPGRAM MICAKLGAFR LLICENSSSD
     AYQKILLNVN ADDVHYALQK NDDL
//