ID   A0A182FR68_ANOAL        Unreviewed;      2126 AA.
AC   A0A182FR68;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=Signaling protein {ECO:0008006|Google:ProtNLM};
OS   Anopheles albimanus (New world malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7167 {ECO:0000313|EnsemblMetazoa:AALB009044-PA, ECO:0000313|Proteomes:UP000069272};
RN   [1] {ECO:0000313|EnsemblMetazoa:AALB009044-PA}
RP   IDENTIFICATION.
RC   STRAIN=STECLA/ALBI9_A {ECO:0000313|EnsemblMetazoa:AALB009044-PA};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00983}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   STRING; 7167.A0A182FR68; -.
DR   EnsemblMetazoa; AALB009044-RA; AALB009044-PA; AALB009044.
DR   VEuPathDB; VectorBase:AALB009044; -.
DR   VEuPathDB; VectorBase:AALB20_026938; -.
DR   Proteomes; UP000069272; Chromosome 2R.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.20.58.740; -; 1.
DR   Gene3D; 1.25.40.410; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR027007; C2_DOCK-type_domain.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR026791; DOCK.
DR   InterPro; IPR043161; DOCK_C_lobe_A.
DR   InterPro; IPR043162; DOCK_C_lobe_C.
DR   InterPro; IPR032376; DOCK_N.
DR   InterPro; IPR042455; DOCK_N_sub1.
DR   InterPro; IPR027357; DOCKER_dom.
DR   InterPro; IPR046769; DOCKER_Lobe_A.
DR   InterPro; IPR046770; DOCKER_Lobe_B.
DR   InterPro; IPR046773; DOCKER_Lobe_C.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR   PANTHER; PTHR45653:SF10; MYOBLAST CITY, ISOFORM B; 1.
DR   Pfam; PF06920; DHR-2_Lobe_A; 1.
DR   Pfam; PF20422; DHR-2_Lobe_B; 1.
DR   Pfam; PF20421; DHR-2_Lobe_C; 1.
DR   Pfam; PF14429; DOCK-C2; 1.
DR   Pfam; PF16172; DOCK_N; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS51650; C2_DOCK; 1.
DR   PROSITE; PS51651; DOCKER; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192}.
SQ   SEQUENCE   2126 AA;  241485 MW;  90246D6F88ED29C0 CRC64;
     MILISLVCSL FPSTAKANYS AADKEHHIDL DVGDTVIIEQ ESYHWYYGRN GSSGTVGVFP
     KAYVHPVESR TSRDGELIIL RSEIVEEITT VLKEWQYHYR RLYLATDPCF KQLQGKMLEL
     IRLRSQLLSG NLPVDEMRNI KLKATSEIDT GNKILQLDMI VRDESGNILD IERTSTTQLY
     EHHLNAVDRI KRANNSTSKN RTPDIVNRHS HNLLLSVYNF VCRLSEDTEI LFTLYDGDEM
     RAITENFVVR WSRQGMAADL DQFNNIKVLF TDLSGNDLSR NKIYLVAYVV RIGAMEGKDT
     ELRRSSMANS VGNGTYKTNR NHITSQMSNP ASPSTGSGGT SSGTPSSTGS LNGVPDLNMR
     RPFGVATLDL KPILRRSEDF KSDTQLKMPF IPCEKEPLEA TLRKLITNKD LGEKSDSAIW
     ISVDMLYGDI KQVRDEYPHL VLGNVAFARK MGFPEVIFPG DVRNDLYLTL VSGEFSKGSK
     SSDKNIEVMA YVCNKQGMTI PGVISYGGGG GALNEYKSVI YYHEDRPKWS ETFKIDVPIE
     EFKQCHLKFT FRHRSSNEAK DRTEKPFGMS FVRLMNDDGT TLQHRRHTLL VYKIDHKKYD
     EESQYNYLNL PSLADELPNG STKPAIAGFS LASKDSFIIE TNLCSTKLTQ NVDILGLLNW
     SSRKEKLEES LHALMKVRCE EVVKFLQDIL DALFNILVDN EDPDKYDKLV FECLLRLIEI
     VYDLKYQHFQ SVLDLYINES FSATLAYEKL IQVVQTDIRN AINSIASTAT INRSASNIYT
     VNENDEKLYR TTKYLQYIIK FIVRSRVLFA ELNQNRGREE FEAGLEQLLE SFTELIKYQN
     DLLKSQGALL KYLHIIASDL MQVYEPLKLG QKIVDIITNV PTGRLNQSKM TCIKDVVDSK
     LFKLPECRAI LLPVFCRQIK DKLESKEEGD FMCDIRQQEK NLIKAAKVLG ESKSQLHTRE
     TTAKTKVAEC VNIMNNMLEL LFQKDADIGP VDGDIRNIML ILLRTVIQSS IAMDRSNPLV
     GNLVAVMLGI FRSMHASHYQ CYVQSFLTSY DLLDFLTEIL LVFQELVSKP VFPADWLDMI
     MHQNTVILES LRHFAGIIMD QFFSPFEKQV WSNYFQCSIT FLTQPSLQLN MFSKTKQSVI
     RSNYRDIRRE TVYEIRKMWF NLGEHKISFV PRLVGPILEM SLIPEEDLRR ATIPIFFDMM
     QCEYYSSRFA TESYGDTRRN TAHIKGNFND FEKEIIEKLD HYIEGGYGDA EYKDLFYDIM
     YESCSSHSTL QTYGVQCVQI LTRLMEKLLE YRCLIHDESK ENRMACTVSL LQFYSDVNRK
     EMYIRYVDKL YELHMEFDNF TEAAYTLKLH SNELSWDETP LSLLLKSKRH ILSSTHRTLK
     EQLYRNMIDL FDKGKMWECA IELCKELAQQ YENEVYDYLS LSELYKRMSI FYENILRTTR
     YESIYYRVTF FGLGFPEFLR NRAFVYRGNE YEDAGSFNMR ILSQHPRAEL LTTLTPEPEV
     QQSEGQFVQI VKVDPVYRDM HFGSKNTQSI ASNIVKFYKS NNVSEFQFSR PIRDSTVGGD
     DIANTSYERT IMRTTDPLPG ILRWFPVKSC ETVMITPIEM AIETVDAKNR AIRDLVLEHQ
     SDPRIPVHSL SAIIKGVVDA AINGGIPIYE EAFLKPEYLD RHPDDDHLVA RLKDLIASQI
     PLLEVALLLH KMKTPASLLP LHDQLEKCFA TIQANVEAKY GKRSTDIKID RDAEVTFRRQ
     TSAMPQLSME SSRLSEASVG SSDSGSSKNQ NSRPTTTSSG GFKNTFANLT NFNTVNLASD
     LFEFDRISLS SFTANGTGGK LITNLSTKIG TKLRQTSLGT SPSSKTKKDK TLTKRRSSRK
     MDRETMSLSI PNSQFYTAPL GTTSEHSYSM MSSDNSRDSA GSVSLLSTTS TVTVGSPISS
     PMNSLPVYEL TEELHPKRPL RSEVEKEKRL SRPPSIATPT MGTKSSVTGV SSNVANGGGD
     TNSIGSADSS SNRNSIITND STTSEEDTVP PPLPLKTSAR CDTGSDYANF GSRTEYRNSS
     QQAVVTNASH YITFKPMLAT PIAEQQHSNK AHDDLANNAS YDTVQTTGNH NIIIINSPTG
     PGAVGMYDDK KRPPTPPPKP ARNVKV
//