ID A0A182FRH0_ANOAL Unreviewed; 2219 AA.
AC A0A182FRH0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
OS Anopheles albimanus (New world malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7167 {ECO:0000313|EnsemblMetazoa:AALB009146-PA, ECO:0000313|Proteomes:UP000069272};
RN [1] {ECO:0000313|EnsemblMetazoa:AALB009146-PA}
RP IDENTIFICATION.
RC STRAIN=STECLA/ALBI9_A {ECO:0000313|EnsemblMetazoa:AALB009146-PA};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003,
CC ECO:0000256|RuleBase:RU000617};
CC -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC {ECO:0000256|ARBA:ARBA00007572, ECO:0000256|RuleBase:RU004196}.
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DR STRING; 7167.A0A182FRH0; -.
DR EnsemblMetazoa; AALB009146-RA; AALB009146-PA; AALB009146.
DR VEuPathDB; VectorBase:AALB017589; -.
DR VEuPathDB; VectorBase:AALB017590; -.
DR VEuPathDB; VectorBase:AALB20_026604; -.
DR VEuPathDB; VectorBase:AALB20_028557; -.
DR Proteomes; UP000069272; Chromosome 2R.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd07900; Adenylation_DNA_ligase_I_Euk; 1.
DR CDD; cd07969; OBF_DNA_ligase_I; 1.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR000977; DNA_ligase_ATP-dep.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR InterPro; IPR036599; DNA_ligase_N_sf.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029257; RAB3GAP2_C.
DR InterPro; IPR032839; RAB3GAP_N.
DR NCBIfam; TIGR00574; dnl1; 1.
DR PANTHER; PTHR45674:SF4; DNA LIGASE 1; 1.
DR PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF04675; DNA_ligase_A_N; 1.
DR Pfam; PF14656; RAB3GAP2_C; 1.
DR Pfam; PF14655; RAB3GAP2_N; 1.
DR SUPFAM; SSF117018; ATP-dependent DNA ligase DNA-binding domain; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000617};
KW DNA damage {ECO:0000256|RuleBase:RU000617};
KW DNA recombination {ECO:0000256|RuleBase:RU000617};
KW DNA repair {ECO:0000256|RuleBase:RU000617};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU000617};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000617}.
FT DOMAIN 505..641
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
SQ SEQUENCE 2219 AA; 246418 MW; D47A1501C08D2C9B CRC64;
MKRRNSPESK KQVATLEKKS PKKSTSPEAK KAAGAQTPPK KSPKNVKKEE KSVTLKEETK
KVKKSPSSPV APASSSSSSV KVEKSSPAKS VNGGGGNNFF TSTKKEPTTN GKAGGSSDGS
DYDPGKKNYH PIKDAFWKKG DRVPYLALAR TFQTIEETSG RLRMIEILAN FFRSVILLSP
SDLLASVYLS LNQLAPAYEG VELGIAEHSL MKAIAQSTGR SLGQIKTDAQ TTGDLGLVAE
QSKSSQRMMF RPAPLTVASV FGKLREIASM IGAASMAKKM DKIQAMFVAC RHSESRFIIR
SLAGKLRIGL AEQSLLQALA QACALTPPEL AGGDSPVVDA LAKEPETKVK ARVDEIALTL
KTVYCQCPNY NQIVPVLLQY GVGEVLERCP MLPGTPLKPM LAHPTKGVQE VLQRFDGLEF
TCEWKYDGER AQIHLLSDGG VQIFSRNQEN NTSKYPDVIG RLEFTRKDTV KSAILDCEAV
AWDVEKRQIL PFQVLSTRKR KDANEADIKV QVCVFMFDLL YLNGQPLVER PFSERRELLY
SHFREIEGQW KYATRLDTGD LDELQRFLDE AVRGNCEGLM VKTLQRDATY EIAKRSRNWL
KLKKDYLTGV GDSLDLVVIG GYRGKGKRTG TYGGFLLACY DADNEEYQTI CKIGTGFSDE
DLQRHTEFLG AHVIPRAKPY YRYEANLEPD DWFEAVQVWE VLCADLSLSP IHQAAVGIVD
PEKGISLRFP RFIRVRDDKG ATDATTAQQV SEMYLNQDQI KNQAAGQGGR DGAERIRTKM
SCEVKVLSVI EDLPEVQEQF GLSADENWLN SVSYSLSPAG DTLALGHGSI LLVLTSRWDR
QRQLNVYRTA WRGAIDDASC NITSILCTPI VGQGQSSQTM VDFSYIIVGL DSGLVLFYGE
TGTLVHSQIF HQEPIQALKA QSGKHINEEL YVMYASCTVI LQGSQVFPLL RSLRQQINRY
GAGSPKVNEA QETIACRKWS YEKGMTIVDA VVVGPQKSCT FDHLLTASLE GGFFAKYRHA
APQNSLIVAA GSKPYVGFHY AKEGFTQPLL ADVARAVASK IKSALPSWLG GGGGSSAQQQ
ASAEPQLPPS EPLICRFGLC DLQRNAFAVW LAPNYQLAAV ADNLGRIILV DCQRGIALRI
WKGYRDAQCG FVEVPEKLPK ESSTASGGSS RKLDRRRALF LVLYAPRRSV LEVWSLRSGG
PKVAAFSAAK NGQLLYNTHS QMGVTSGASK IKYSGYGCTF LDPSDNSLKE IVIPFHCALS
DSKSKMAKDL HLLKRLKVCI KSGDGSETEE LDELSDMCRC FETDEIRLQC VEMLAKQRRI
RPRLFAAAVD FFAEASLEGP TASSVASTTA GSMITAEMEQ EEEIETRSEC VLLSKSTLRI
MCENYQRLVM FYLYLHGDMP TMDGEQKPPD ETENECSREG QLSEQEITVI EQLIDLLRMN
NATKEIVQNA GNTSGSAGVG ASSTGAPKGV KFEESVGSGV RNTSFMEYLS SFNVTNDELI
LLREEHGASA YAGLGKIIFE ALYQEDDGRI ARLNGFLSAA EASGLMPEDL LRVFLAYWLR
LPFVYQDMAA LLDDLDRFNA VLHQICLLAR DKIIFDNNTI CLWWQSVREY LLESPCALRG
LLAALMCRNE ALRHEHRRRS VEEEVSERFE EVTQEACQWT LLIDKLEDVA ILGTILAEGV
RCLHPQWPTL KYHKPTVSLK EILTGGKGII GELVAKWIAS TGIEPDMLVI EVPPEATETD
PKPAPLTDTK ASPEKVLPTR NDRRERNRQL ALIKANLLQT SEYGPDERDG DEETKEQLDP
VLYNLNILRL HFPFSLDSGQ LLAQLAWEYI GAWSRNMANI ACLKAGLACL HAIPRLQYSI
KHGLCCMVWN AHLKIPLEAT KKLVNKVGRL PKEKLCLQDI GISDALVPQF LECCLEFFEH
FAGSIDHDKL EPRFEELLQE GPVPLTVLAV QQNSANMALL RLHQELTLVL LMLTSFNVRY
ASKPIQQLFD GMANQAFFAE INRQLSANSA LPKADQLLRK TRLEFLCRTV TATMDLIHEE
MQVVYYTDHN DWMEKVERLA SAWELEFGDI RKHQIIELYA HGWDTYAHEL LENVIPDQTF
ANLLLTIAGR RLALYTKANP STWGQIAAVG PLLTDYLDTL VSNGNYGPPL RFAGLEEETL
QTAAGAEMFI EKITKLTEKA FNALSALAVN AKGTSKELRI AGLIFDACAT IKDHQPRRK
//
