ID A0A182FZQ9_ANOAL Unreviewed; 823 AA.
AC A0A182FZQ9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000632};
DE EC=2.7.10.2 {ECO:0000256|PIRNR:PIRNR000632};
OS Anopheles albimanus (New world malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7167 {ECO:0000313|EnsemblMetazoa:AALB015498-PA, ECO:0000313|Proteomes:UP000069272};
RN [1] {ECO:0000313|EnsemblMetazoa:AALB015498-PA}
RP IDENTIFICATION.
RC STRAIN=STECLA/ALBI9_A {ECO:0000313|EnsemblMetazoa:AALB015498-PA};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001149,
CC ECO:0000256|PIRNR:PIRNR000632};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. Fes/fps subfamily. {ECO:0000256|PIRNR:PIRNR000632}.
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DR AlphaFoldDB; A0A182FZQ9; -.
DR STRING; 7167.A0A182FZQ9; -.
DR EnsemblMetazoa; AALB015498-RA; AALB015498-PA; AALB015498.
DR VEuPathDB; VectorBase:AALB015498; -.
DR VEuPathDB; VectorBase:AALB20_028143; -.
DR Proteomes; UP000069272; Chromosome 2R.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0065008; P:regulation of biological quality; IEA:UniProt.
DR CDD; cd07657; F-BAR_Fes_Fer; 1.
DR CDD; cd05041; PTKc_Fes_like; 1.
DR CDD; cd10361; SH2_Fps_family; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR035849; Fes/Fps/Fer_SH2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR016250; Tyr-prot_kinase_Fes/Fps.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR24418:SF418; TYROSINE-PROTEIN KINASE FER; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF00017; SH2; 1.
DR PIRSF; PIRSF000632; TyrPK_fps; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR000632};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000632};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000632};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000632};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW ECO:0000256|PIRNR:PIRNR000632}.
SQ SEQUENCE 823 AA; 93574 MW; 03A846931CDD4452 CRC64;
MGFSSALQGR AAHDALLNRQ EAELKLLETM KRCLAQKAKC DREYAVSLAA VTQQGLKIDR
TDDLQGSHIM RAWRGFMEEL EHTAKQIRSN AEQLETVCHE KLASLYQEKR RVRKQYQEEH
TKIATQFSHL TEDVARKKSE YQKHLDYYKL LRGRFEEHIK SGRSGRKLDD VIDKYQKACR
KLHQAHNEYV LLISEAVEVE KDFRTTLLPG LLEHQQTLQE GFIQAWSNLL SEIAKLSDTT
SEKYVEIQRR IDASISSINS TEEYREFTDK HKTSPTTPVV FQFDESLVED SLGKLQANTL
TVDNLTVDWL RSRQVELEST IKDLQERQAK LLAEPNGTAG TLATSSSSPA SSSPVSTPGT
KPSTPILNGT GSTVASGKDS QQMTANKSSK ELNNLRCQER QTMKLVEMIR TALNEVGCEE
LPSGCDDIAV EHLIENKKSV SQDLSMTLST NRPLHEEEWF HGVLPREEVV RLLRNEGDFL
VRETTRNDES QTVLSVCWNG HKHFIVQTTA EGHYRFEGPA FPSIQELIVH QYQSELPVTG
RSGAVLRKPV LRERWELSND DVILLDKIGR GNFGDVYKAK LKSSKNTLVA VKTCRMTLPE
EQKRKFLQEG RILKQYDHPN IVKLIGICVQ KQPIMIVMEL VAGGSLLMFL RKNASTLGQR
QMMGMCRDAA AGMRYLESKN CIHRDLAARN CLIGSENIVK ISDFGMSREE EEYIVSGGMK
QIPIKWTAPE ALNFGKYTSL CDVWSYGILV WEIFSRGDTP YSGMSNSMAR ERIDEGYRMP
SPEGAPPEMY RLMLKCWSYE PESRPHFDEI YTVVDALILC TKD
//
