ID A0A182G0C9_ANOAL Unreviewed; 621 AA.
AC A0A182G0C9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein {ECO:0000259|PROSITE:PS00624};
OS Anopheles albimanus (New world malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7167 {ECO:0000313|EnsemblMetazoa:AALB015708-PA, ECO:0000313|Proteomes:UP000069272};
RN [1] {ECO:0000313|EnsemblMetazoa:AALB015708-PA}
RP IDENTIFICATION.
RC STRAIN=STECLA/ALBI9_A {ECO:0000313|EnsemblMetazoa:AALB015708-PA};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR AlphaFoldDB; A0A182G0C9; -.
DR STRING; 7167.A0A182G0C9; -.
DR EnsemblMetazoa; AALB015708-RA; AALB015708-PA; AALB015708.
DR VEuPathDB; VectorBase:AALB015708; -.
DR VEuPathDB; VectorBase:AALB20_036489; -.
DR OrthoDB; 3382025at2759; -.
DR Proteomes; UP000069272; Chromosome 2R.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF158; GH23626P-RELATED; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR000137-2}.
FT DOMAIN 311..325
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT ACT_SITE 552
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-1"
FT ACT_SITE 596
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-1"
FT BINDING 138
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 274
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 621 AA; 69588 MW; A7F953F267C3FC38 CRC64;
MAPASAMQYL PLAAGILGMV SFSRPQDTLM SMLSFLQEGG QDLKHELPDQ PTLRPEYDFV
IVGAGSAGSV LASRLSEVPE WSVLLIEAGP SENLLMDIPM AAHYLQGFNI NWDYRTKPSN
TSCLGFKNRQ CRLPRGKVMG GSSVLNYMIY TRGNRRDFDQ WADQGNPGWS YQDVLPYFRK
LERSRIPNTS PGYAGKDGRL TISYPRYRSA IATAFVQSAM EGGAPYVDYN GPHQIGVSYI
QSTTKDGKRQ SANVAYLHDL HARTNLHVKK QAQVTRIMLD RATNRATGVR FYSAGRIQSV
RARREVIVSA GAIGSPHLLM LSGIGPAGHL RENGIKPVVD LPVGYNFQDH TAAGGLTFLV
NNTDTMKYSQ IFHLDKFMEY QYNKTGPFTS IGGCESIAFY DSEHPTDPDG WPDYELIQIG
GTLAADPTYE HNFNYRPDAF KQLFGEVQKR KLDGYTVFPM VLRPRSRGRI SLNGSNPFRH
PVIEPNYFAD PYDLEVSVRA IRKAIELSEM DGLRHFDARL MRSRMPGCER YVFDSDDYWK
CFTRHATFTI YHHVGTCKMG PRRDPTAVVD ARLRVHGVKG LRVIDASIMP NVPAGHTNAP
TIMIGEKGAD MIKEDWNELT E
//
