ID A0A182G438_AEDAL Unreviewed; 602 AA.
AC A0A182G438;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=cytochrome-b5 reductase {ECO:0000256|ARBA:ARBA00012011};
DE EC=1.6.2.2 {ECO:0000256|ARBA:ARBA00012011};
GN ORFNames=RP20_CCG002514 {ECO:0000313|EMBL:KXJ83737.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EMBL:KXJ83737.1};
RN [1] {ECO:0000313|EMBL:KXJ83737.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ83737.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ83737.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ83737.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ83737.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ83737.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the flavoprotein pyridine nucleotide cytochrome
CC reductase family. {ECO:0000256|ARBA:ARBA00006105}.
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DR EMBL; KQ560227; KXJ83737.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182G438; -.
DR STRING; 7160.A0A182G438; -.
DR VEuPathDB; VectorBase:AALC636_024097; -.
DR VEuPathDB; VectorBase:AALF002514; -.
DR VEuPathDB; VectorBase:AALFPA_047997; -.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0004128; F:cytochrome-b5 reductase activity, acting on NAD(P)H; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd06183; cyt_b5_reduct_like; 1.
DR CDD; cd06490; p23_NCB5OR; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR008333; Cbr1-like_FAD-bd_dom.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR018506; Cyt_B5_heme-BS.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR037908; p23_NCB5OR.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR46237:SF1; CYTOCHROME B5 REDUCTASE 4; 1.
DR PANTHER; PTHR46237; CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF00970; FAD_binding_6; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00406; CYTB5RDTASE.
DR PRINTS; PR00363; CYTOCHROMEB5.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS00191; CYTOCHROME_B5_1; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000249989}.
SQ SEQUENCE 602 AA; 65794 MW; DB2EA0A2321876EE CRC64;
MVRTLDYHAE DLGSNPTPDK LAKCNPRNKT ALKPGHSLMD WIRYGNSGVD LAGTGGRVRP
VQHTELATHN KPGDVWMAIR GKVYNVTSYL DFHPGGVDEL MRGAGKDATK LFDEVHAWVN
YESLLAKCYI GPLRSTGVLK LVPEEPETTS KSPSSSMPPP SPVFLKPPSS SNPSVIVTPS
TPAVAPKVLS ATSVVSSSSE DSAIKLSPVV PRFDWIQKTA EVTFIFYTKA LCNPAVVVEF
VNNLEFNVRI FLEGNVLHRY QFQVTNNLQW PCTVRQSLEA GKVELVFNKL LPSLWTNYGQ
MEHDQIENYP MELHEYDVAT RIEITHDSCA LLLRPKNNSI LQVTPIGHHL SISGTVAEGQ
VVTRSYTPVP PAAVPTDCPP TFIPLLVKTY PLGALSKHLT RPVPLATSLQ ISQPSGNFSL
AKLKHHNRIA LLAAGSGITP MLALLSYLLE RSSNKMESIC LLYFNKTEAD IWCREMLDNL
CAKDKRLTVK HFLSDVESPT TVQPPPTSAK SPGPDDSRPS TSTTVAGSAD EDGSSRPPKA
TATAEFERGR ISLAIVQQLT NVDSPLAASF VCLCGPKPFN ELACQHLEQA GHSMSYVHSF
QG
//
