ID A0A182G7S2_AEDAL Unreviewed; 562 AA.
AC A0A182G7S2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=polo kinase {ECO:0000256|ARBA:ARBA00012424};
DE EC=2.7.11.21 {ECO:0000256|ARBA:ARBA00012424};
GN ORFNames=RP20_CCG004782 {ECO:0000313|EMBL:KXJ78382.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EnsemblMetazoa:AALF004782-PA.1, ECO:0000313|Proteomes:UP000069940};
RN [1] {ECO:0000313|EMBL:KXJ78382.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ78382.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ78382.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ78382.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ78382.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ78382.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:AALF004782-PA.1}
RP IDENTIFICATION.
RC STRAIN=Foshan {ECO:0000313|EnsemblMetazoa:AALF004782-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.21;
CC Evidence={ECO:0000256|ARBA:ARBA00000540};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.21; Evidence={ECO:0000256|ARBA:ARBA00000856};
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DR EMBL; JXUM01046986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KQ561499; KXJ78382.1; -; Genomic_DNA.
DR RefSeq; XP_019526849.1; XM_019671304.1.
DR AlphaFoldDB; A0A182G7S2; -.
DR STRING; 7160.A0A182G7S2; -.
DR EnsemblMetazoa; AALF004782-RA; AALF004782-PA; AALF004782.
DR VEuPathDB; VectorBase:AALC636_000104; -.
DR VEuPathDB; VectorBase:AALF004782; -.
DR VEuPathDB; VectorBase:AALFPA_079138; -.
DR Proteomes; UP000069940; Unplaced.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13118; POLO_box_1; 1.
DR CDD; cd13117; POLO_box_2; 1.
DR CDD; cd14099; STKc_PLK; 1.
DR Gene3D; 3.30.1120.30; POLO box domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033701; POLO_box_1.
DR InterPro; IPR033695; POLO_box_2.
DR InterPro; IPR000959; POLO_box_dom.
DR InterPro; IPR036947; POLO_box_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24345; SERINE/THREONINE-PROTEIN KINASE PLK; 1.
DR PANTHER; PTHR24345:SF0; SERINE_THREONINE-PROTEIN KINASE PLK1; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00659; POLO_box; 2.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF82615; Polo-box domain; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50078; POLO_BOX; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000249989};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 26..278
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 385..448
FT /note="POLO box"
FT /evidence="ECO:0000259|PROSITE:PS50078"
FT DOMAIN 483..551
FT /note="POLO box"
FT /evidence="ECO:0000259|PROSITE:PS50078"
SQ SEQUENCE 562 AA; 65020 MW; 8F49010E985C13F7 CRC64;
MSSIKPDDKS SDIPEKLYDA TARRTYKRLR FFGKGGFAKC YEIMDVVTGE VYAGKIVSKK
LMMKHNQKEK MTQEITIHKS LNHRNIVGFH SFFDDPLNIY IVLELCKKRS MMELHKRRKV
ITDYECRYYI HQVLTGVKYL HDRHIIHRDL KLGNLFLNDD LHVKIGDFGL ATKIEFEGER
KKTLCGTPNY IAPEILNKKG HSYEVDVWSI GCVMFTLLVG QPPFETKSLK DTYTKIRKCD
YRLPSTVRTN AAEMICSMLQ SDPLKRPSVT QMFDFDFMCS AHIPASLPIS CLTMAPRADQ
LENVDRMDDT RLESSFLKNN LHDAITASGT MSRHNEGYRT DIENLYKQLS TLIASKPPKL
ATNLDDENTD PAVQPLFWVS KWVDYSDKYG FGYQLCDEGM GVMFNDTTKL IMLANGLNVH
FIDKEGVETY MDIHNYPPQM EKKMKLLSYF KRYMTEHLVK AGAGAVNIES DQLSRIPHLH
TWFRTMCAVV MHLTNGTVQL NFSDHQKIIL CPLMRAVTLM DNNKNFRTYR FSTIQEQGCS
SDLYQKIRYA HEKLKKLLEK LS
//
