ID A0A182GA91_AEDAL Unreviewed; 304 AA.
AC A0A182GA91;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=GPN-loop GTPase 2 {ECO:0000256|ARBA:ARBA00014588, ECO:0000256|RuleBase:RU365059};
GN ORFNames=RP20_CCG006225 {ECO:0000313|EMBL:KXJ83492.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EnsemblMetazoa:AALF006225-PA.1, ECO:0000313|Proteomes:UP000069940};
RN [1] {ECO:0000313|EMBL:KXJ83492.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ83492.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ83492.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ83492.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ83492.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ83492.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:AALF006225-PA.1}
RP IDENTIFICATION.
RC STRAIN=Foshan {ECO:0000313|EnsemblMetazoa:AALF006225-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- FUNCTION: Small GTPase required for proper localization of RNA
CC polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC step prior to nuclear import. {ECO:0000256|ARBA:ARBA00003181,
CC ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II (RNAPII).
CC {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR EMBL; JXUM01008452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KQ560261; KXJ83492.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182GA91; -.
DR STRING; 7160.A0A182GA91; -.
DR EnsemblMetazoa; AALF006225-RA; AALF006225-PA; AALF006225.
DR VEuPathDB; VectorBase:AALC636_019368; -.
DR VEuPathDB; VectorBase:AALF006225; -.
DR VEuPathDB; VectorBase:AALFPA_064400; -.
DR OMA; ATHNYFL; -.
DR OrthoDB; 168004at2759; -.
DR Proteomes; UP000069940; Unplaced.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd17871; GPN2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030231; Gpn2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF3; GPN-LOOP GTPASE 2; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059};
KW Reference proteome {ECO:0000313|Proteomes:UP000249989}.
SQ SEQUENCE 304 AA; 34564 MW; AE5A206FB1F1C8DC CRC64;
MQNKVVTLRT QSPLYGQLVI GPPGSGKTTY CAKMKQFLEK LERKVTVVNL DPANDNMEYE
TTIDIMQLIT VEDVMEQFNL GPNGALIYCM EFLETNFGWL LEQLKASPDK YFIFDCPGQV
ELYTHHNSMK NIFEQLEKLG YHLCTVHLVE SHHCSEPHKF ISTLLLSLHT MLQMGLPHVN
VLSKADLLKE YESKLAFNLE YYTDVLDLNY LLESVDNSMG PKNKYKKLNA AIVSMVEDYS
LVSFCLLDCN RDDSLLRLKN AIDKANGYVY GAGEEKNVNT LLACAVGAET QTDRMERDVN
PYVS
//
