ID A0A182GAA8_AEDAL Unreviewed; 300 AA.
AC A0A182GAA8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN ORFNames=RP20_CCG006254 {ECO:0000313|EMBL:KXJ77878.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EnsemblMetazoa:AALF006254-PA.1, ECO:0000313|Proteomes:UP000069940};
RN [1] {ECO:0000313|EMBL:KXJ77878.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ77878.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ77878.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ77878.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ77878.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ77878.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:AALF006254-PA.1}
RP IDENTIFICATION.
RC STRAIN=Foshan {ECO:0000313|EnsemblMetazoa:AALF006254-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000256|RuleBase:RU079119}.
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DR EMBL; JXUM01050835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01050836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01050837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01050838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01050839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01050840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01050841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01050842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01050843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KQ561664; KXJ77878.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182GAA8; -.
DR STRING; 7160.A0A182GAA8; -.
DR EnsemblMetazoa; AALF006254-RA; AALF006254-PA; AALF006254.
DR VEuPathDB; VectorBase:AALC636_021379; -.
DR VEuPathDB; VectorBase:AALF006254; -.
DR VEuPathDB; VectorBase:AALFPA_065892; -.
DR Proteomes; UP000069940; Unplaced.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR PANTHER; PTHR12246; PALMITOYLTRANSFERASE ZDHHC16; 1.
DR PANTHER; PTHR12246:SF13; PALMITOYLTRANSFERASE ZDHHC16; 1.
DR Pfam; PF01529; DHHC; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU079119};
KW Membrane {ECO:0000256|RuleBase:RU079119};
KW Reference proteome {ECO:0000313|Proteomes:UP000249989};
KW Transferase {ECO:0000256|RuleBase:RU079119};
KW Transmembrane {ECO:0000256|RuleBase:RU079119};
KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT TRANSMEM 36..59
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 65..87
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 187..210
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 222..250
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT DOMAIN 143..259
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 300 AA; 35155 MW; DA350C8510ADEC98 CRC64;
MSITGNYDHY HRSGSTGSGG SDRPERCACC VRTMKWFPVL FIVSVIGWSY YAFVVQLSFF
TVTSVVQRIL FLLFYHLILI MFLWSYYQTV FTDIGRVPSR FRVPRSELDR LLRATSEEEQ
KQILEAFAKE LPIVTRTLNA SVRFCEKCRL IKPDRAHHCS VCGVCVLKLD HHCPWVNNCI
NFTNYKYFIL FLGYALLYCL YIAFTTVMYM ELIWSGKVDG RFHILFLFFV SLMFAISLVS
LFGYHCYLVL LNRTTLESFR TPIFRYGGPD KNGFSLGKFN NFQEVFGDDR KLWFVPVYTR
//
