ID A0A182GB67_AEDAL Unreviewed; 575 AA.
AC A0A182GB67;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=G-protein coupled receptors family 2 profile 2 domain-containing protein {ECO:0000259|PROSITE:PS50261};
GN ORFNames=RP20_CCG006783 {ECO:0000313|EMBL:KXJ77715.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EnsemblMetazoa:AALF006783-PA.1, ECO:0000313|Proteomes:UP000069940};
RN [1] {ECO:0000313|EMBL:KXJ77715.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ77715.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ77715.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ77715.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ77715.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ77715.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:AALF006783-PA.1}
RP IDENTIFICATION.
RC STRAIN=Foshan {ECO:0000313|EnsemblMetazoa:AALF006783-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JXUM01052188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KQ561724; KXJ77715.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182GB67; -.
DR STRING; 7160.A0A182GB67; -.
DR EnsemblMetazoa; AALF006783-RA; AALF006783-PA; AALF006783.
DR VEuPathDB; VectorBase:AALC636_004357; -.
DR VEuPathDB; VectorBase:AALF006783; -.
DR VEuPathDB; VectorBase:AALFPA_073816; -.
DR Proteomes; UP000069940; Unplaced.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF473; FI21270P1-RELATED; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000249989};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 516..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 218..378
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 95..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 575 AA; 64635 MW; 35C9C3DE85C122AB CRC64;
MTRGSGPGVM VRTLDCHAED LGSNPTPVKL AKSKATAARL KYPNYEARYI NDFINYTRPA
ADIMEPIFYD YDAEPSRKAY NREYEEGVAE LGYRVPPLPL AMDPPEDGTS STSSSSSSSS
AASQETEVTR PPDIYPDPDH IYATFLNKST MKRNRFPGEE NVIKVYSGKS LRKSPQARID
DDGSFDSLNN DMKGHDFIDN IMYIYYGTNG TLRKDLGGNV IVIGAVFALA PQILTAIILF
LRNRRPRHFN TFYPICLNLL LSLAASNFAF VLGVQATRNP VKCELIAIVL HYLHLCTSIW
CFIYIYVIYD LIVNECGPKL KYNYLMGYGV PAVYVLFSYA SSIDTFEVRH YCWMSIQKGM
IVSFMIPISF LIILTTVLGT ISLKRISSKQ TAILCESIES IIETTSKCND IMFPRLPSVG
AQLANRSNSY PQLELKEKCC QEYANQTMEN RQSVVTLPQQ TTIGHHHGFS VSGFKKSLEC
YDTRIDLGQL SLAELSTPSL ASDIQDFTEF KRAIKFGLFF QPIYSICWFL SVIALENMHS
CVMPVIFAIC LNILVSTLNV YEEELPGKHK SFVTC
//
