ID A0A182GDE0_AEDAL Unreviewed; 1399 AA.
AC A0A182GDE0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=RP20_CCG007993 {ECO:0000313|EMBL:KXJ77263.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EnsemblMetazoa:AALF007993-PA.1, ECO:0000313|Proteomes:UP000069940};
RN [1] {ECO:0000313|EMBL:KXJ77263.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ77263.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ77263.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ77263.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ77263.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ77263.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:AALF007993-PA.1}
RP IDENTIFICATION.
RC STRAIN=Foshan {ECO:0000313|EnsemblMetazoa:AALF007993-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S1 family. CLIP subfamily.
CC {ECO:0000256|ARBA:ARBA00024195}.
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DR EMBL; JXUM01055673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KQ561879; KXJ77263.1; -; Genomic_DNA.
DR STRING; 7160.A0A182GDE0; -.
DR EnsemblMetazoa; AALF007993-RA; AALF007993-PA; AALF007993.
DR VEuPathDB; VectorBase:AALC636_028209; -.
DR VEuPathDB; VectorBase:AALF007993; -.
DR VEuPathDB; VectorBase:AALFPA_042398; -.
DR Proteomes; UP000069940; Unplaced.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000249989};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 17..140
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 360..398
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 1171..1397
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 1399 AA; 158730 MW; 1324761AD713187A CRC64;
MTDFSQQLLL KFLQEFIQGF TDLSEKFNQP GKGGASKLSQ VLNAYLGAMV QEILSHGGDI
LKFSGDAFLV LFKETSSVSL QDATHRAIDT AIIIQRSFGA YKTEVGVTLR VKIAISAGEV
YFSLIGTEDF SHYVVIGQPV WKVKIAEKVA VAGDIIVNHL AWNYIHPNEY ISEQCDDKVH
FRIKGFTSNW RSAQRLNIFD LLHENELEDD DDSRVVAGEE MKLDSETLGI RPSLKHVATK
TLTTSLRRFM IKPILNAIDT QEPLEFLTEM RQIVTVFLNI VLRTKDMLVV IEEINSIFTS
LCTLVESYEG TVNKVSLFDK DVMFLIIFGL RGYKHDLDSQ IALRCASEIR ELYRTNPKVL
SASIGVTTGS TYCGVVGHFV RREYSVISVT VNKAARLMMA YPNKVTCDKD TFMMSKLDPM
HFLLQEAIEL KGLQNVGTIY EFKEVIPERE MIKPQEYDYP IVGRDEILEV FQEMLDDGLY
LTQTMNGDDI SRIQDYTNQS CLLIRGEAQM GKTRLLNELF HISLKNKKIS SLRLTLSMRD
LKKAYSAAYL YLSRPLGFTE TITSITRENR IKQYLSEYHL NPQLALLNDI LDVEFPKTEM
LRMMNDTEQN EIKRKLFDLL CQKAFQNLWV LIIDDLEFMD DESLELFEIL WKMPQVITVL
ALGYRRRLAT PFKRLFDNPH VCQLKLTPID TLLHKAVTCQ FLNVNAIPLD LERAIHTMSS
GNPGWMNTFV MSLKQSGLLR ITRMGSIEAQ AKGYVFCESS FLIRSSARST ISFRMSGADW
DLFESCSDDD QMYPFVQANF SSKLVDVACL KGEIDTQNYF PSSCLDAFHL MLYDSLSSYE
QYVCKCAAVL GEKFLRVALI FVIAQDNERD VAIAVQKLFD LQILSCAIGD FSAGFSLFQR
NVNTENLKKR TCGCIKVPVT RACRDLPRYA ACGYSKFNSN QFRQTVYNLL TEEQKVEFHS
RALTFIERET KKCATCGGGP FSNLLSSDDQ FDVLMGFKRR RESDVSYRNL LFKSGASGFS
VHSDKHFKLL NCFSAPKPFP FTAKIPILSY REYDFTKCRC YMTLYSMYKE IVYHSNGARM
AEKHIEAQIE WSNCCMKVAN IPKAIQMLES VQKQIKDIDN FDNIAFVAYL KGRLYTLLAM
CRYELKQYTL ATEYFYTASE VMGMPFPKST IVGGQFAEDE KRFPYQAALF EHDEFKCGGS
IIAEKWILTA THCITQPDGT NTPTDSLKVL VGSHHLKEGG KKVKIAKIIP YVDDDYPKIK
YDIGLIKMEE ALVLDTAIQT LELYRGELPV NATVTISGHG KTGSGEPISE VLKHNTMIVM
SEGDCSNEVV NSGWKKIFCV NNAVDNGVCS GDSGSPAVYE GKQLGVANFV LGKCGSERPD
GYAFVPFFVD WIEKTMEKE
//