ID A0A182GE03_AEDAL Unreviewed; 555 AA.
AC A0A182GE03;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KXJ77115.1};
GN ORFNames=RP20_CCG008287 {ECO:0000313|EMBL:KXJ77115.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EMBL:KXJ77115.1};
RN [1] {ECO:0000313|EMBL:KXJ77115.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ77115.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ77115.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ77115.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ77115.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ77115.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the phosphoglycerate
CC mutase family. {ECO:0000256|ARBA:ARBA00008408}.
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DR EMBL; KQ561934; KXJ77115.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182GE03; -.
DR STRING; 7160.A0A182GE03; -.
DR VEuPathDB; VectorBase:AALC636_031607; -.
DR VEuPathDB; VectorBase:AALF008287; -.
DR VEuPathDB; VectorBase:AALFPA_044039; -.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR GO; GO:0006000; P:fructose metabolic process; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR003094; 6Pfruct_kin.
DR InterPro; IPR013079; 6Phosfructo_kin.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001345; PG/BPGM_mutase_AS.
DR PANTHER; PTHR10606:SF44; 6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM; 1.
DR PANTHER; PTHR10606; 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE; 1.
DR Pfam; PF01591; 6PF2K; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR PRINTS; PR00991; 6PFRUCTKNASE.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00175; PG_MUTASE; 1.
PE 3: Inferred from homology;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000249989}.
FT ACT_SITE 256
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT ACT_SITE 325
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT BINDING 255..262
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
FT BINDING 305
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 555 AA; 65102 MW; D29E2201F3E19076 CRC64;
MAAPAEDKNN DNMKSLGWKF LHKETFGIGE RANYVNSPHV IAMVGLPARG KTYISKKLSR
YLNWIGINTR VFNLGEYRRL ATDAYRSHEF FRPDNEVAMA IRQHCAEMAL QDVCQWLENG
GEVAVFDATN STRERRRMIK DIIVHKMGFK LFFVESICDD PQIIEQNIME VKVSSPDYRN
MNMEEALNDF RLRIEHYQER YEPLVEEIET DLSYMKIYNT GEKVVVHKHE GHIQSRIVYY
LMNIHITPRT IYLTRHGESE HNLKGLIGGD SVLSDRGRRY SQALAKYIQE QHIEGLRVWT
SWLKRTIQTV ADVTAPQERW KALNEIDAGI CEEMTYEQIQ AKFPEEFKAR DQNKFAYRYP
RGESYEDLVV RLEPVMMELE RQGNVLVVSH QAVLRCVLAY FLDKTADELP YLKVPLHTII
KLTPVAYGCK VEHIKLPIDA VDTHRAKPEG KSQKEYQEEY PKDDQEISQK DFQVQSQKAF
QTEFSKDFQE ESSKEFQEEW TSRSNPRKSF RRRDEYLKVL LSEYLRELLK VFLMKLLKAS
LNPPGRTTEL LGRFL
//
