ID A0A182GF78_AEDAL Unreviewed; 1578 AA.
AC A0A182GF78;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Guanine nucleotide exchange factor for ras-like small gtpase {ECO:0008006|Google:ProtNLM};
GN ORFNames=RP20_CCG008892 {ECO:0000313|EMBL:KXJ76787.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EnsemblMetazoa:AALF008892-PA.1, ECO:0000313|Proteomes:UP000069940};
RN [1] {ECO:0000313|EMBL:KXJ76787.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ76787.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ76787.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ76787.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ76787.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ76787.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:AALF008892-PA.1}
RP IDENTIFICATION.
RC STRAIN=Foshan {ECO:0000313|EnsemblMetazoa:AALF008892-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
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DR EMBL; JXUM01059533; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01059534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01059535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01059536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01059537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01059538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01059539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KQ562059; KXJ76787.1; -; Genomic_DNA.
DR STRING; 7160.A0A182GF78; -.
DR EnsemblMetazoa; AALF008892-RA; AALF008892-PA; AALF008892.
DR VEuPathDB; VectorBase:AALC636_024067; -.
DR VEuPathDB; VectorBase:AALF008892; -.
DR VEuPathDB; VectorBase:AALFPA_047747; -.
DR Proteomes; UP000069940; Unplaced.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF373; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00620; HISTONEH2A.
DR SMART; SM00233; PH; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00135};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000249989}.
FT DOMAIN 208..394
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 439..542
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 591..742
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT REGION 837..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 932..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1015..1057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1140..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1197..1244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1343..1419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1494..1578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..965
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1015..1032
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1229..1244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1361..1377
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1401..1415
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1509..1542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1554..1572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1578 AA; 173119 MW; E9EE2EEFB5D4DF39 CRC64;
MFAGGQHVSI TDATDYDFEK AENAAKWKGV FITSLRKVLE QVHPSLQARE DALLYVESLC
LRLLAMLCAK PPPHTVVDVE ERIGRTFPTP IDKWALDEAR ETIDKSKKKK PVLPVDRVHT
LLQKEVLQYK IDSSVSLFLV AVLEYISADI LKLAGNYVKN IRHIEISRED IEVAMCADKV
LMDMFYQGDN SSSMAPSPLP PTPRTSLSYE EVVKELIHDE KQYQRDLHMI IRVFREELVK
IVKEPKELDP IFSNIVDIYD LSVTLLGSLE DVIEMSQEQT PPCIGSCFEE LAEAAEFDAY
ARYAKDITSL QAKEALANLL SRPEANSLMS AGHGFREAVK FYLPKLLLGP IGHAQLYLDY
IKILLQLSPS QEDKESFEQV QGLLKPLQCE LQGISSLLPK EYFARVNSRA RRQSAIEKTR
DLQNSVEHWD KDVGQCCNEF IREDTLAKLS SGKRQTERKV FLFDGLLVLC KTRRQIVPGN
NYDYRLKERF FMRKVEIIDR PDTEELKYAF EISPREPTSV VLIAKNAQHK NDWMADLVML
NTKSMLERIL DSILLDIEKK HPLKLPSPDK YAFAVPDSPS NIVLEEREGT GVPLIKGATL
TKLIERLTYH IYADPMFVRI FLTTYRSFCS PKELLRLLVE RFQIPEPGQV NDSASDKDLV
SDTDKFHKNS QREDVKRFKK EYMQPVQFRV LNVLRHWVDH HFYDFERDSE LLEELLKFLE
TVAGKPMRKW VDSVLKIVQR KNESEESHRQ ITFAYGNSPP AIEHHLPLNI GENEYNLLIL
HPLELARQLT LLEFEMYKNV KPSELVGSVW TGKDKETTSP NLLRIMHHTT NARKWPDISL
KSPGIKPRRH NSSANSSLNL TGTLPFINKA PLGNNNNIDT GSGAEQQSPT ASSSSSSVLD
YSIFAPVNIT NPSWTTSRHV FPYHQDPDKH MPPLHVIYPH RHNQLPPVPS SSLAAGGQQQ
NNHHFYNYHH GHQHSLSQSV VNLASTADQQ MAPEIPRRSD SIILTTSSLS SHTQYNLNNS
SLSESSSNTG DGGGVGGIRL HPSPRYPSSS MSALSSSSSG ISSSSIYGVM SASNSDGNSN
NNPTTTASFK HTPLLSQNKT VVNPYAEDNP HSILSASGVG GGGSLSLSSS SSTNAASIVS
LSDGPAVPQP PPPNAAGMAT SPCTTISSPS ASSSSTAVTA VGVGPSYGAG ATTVFAASPS
STDIPPAISP RTDRPVCPPP APSRNHGGGS GPTEFSYNTS GLPTSPLATA GSSFRISSSN
TVRNQNCDFT TATGNHSSCE NSPIFPSSPH ILPMGGGQAS VMDFNNCATS PTLSTSVSST
SSVYQTTFNA SSTTADSMIL NTTAASNDLG PPHSPHVNVP NTHNIPPPMP PPLPPRVRRR
ESSGESSQSA QVRQAPDAPR LPPRDISPPP LPPRIHSHSH YSFGNVQQQQ QLAHSSGAFD
SWNHINVLPD ESPSSSSSSS TLTRDNLNQH NMSTTQQALM LPHTSTIMMR RNSAMDRGSR
EKVPNIAASP SLSGLSSATA TTTAVGGAAG TSVGSGPVSL PSTSGVAPPP PCGTKNKSVQ
NSPVSQQQQP PVRDRRTR
//
