ID A0A182GN84_AEDAL Unreviewed; 730 AA.
AC A0A182GN84;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=phosphoenolpyruvate carboxykinase (GTP) {ECO:0000256|ARBA:ARBA00012306};
DE EC=4.1.1.32 {ECO:0000256|ARBA:ARBA00012306};
GN ORFNames=RP20_CCG012840 {ECO:0000313|EMBL:KXJ74854.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EMBL:KXJ74854.1};
RN [1] {ECO:0000313|EMBL:KXJ74854.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ74854.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ74854.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ74854.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ74854.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ74854.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the phosphoenolpyruvate carboxykinase [GTP]
CC family. {ECO:0000256|ARBA:ARBA00005796}.
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DR EMBL; KQ562915; KXJ74854.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182GN84; -.
DR STRING; 7160.A0A182GN84; -.
DR VEuPathDB; VectorBase:AALC636_008459; -.
DR VEuPathDB; VectorBase:AALF012840; -.
DR VEuPathDB; VectorBase:AALFPA_041090; -.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004613; F:phosphoenolpyruvate carboxykinase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0043648; P:dicarboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0006094; P:gluconeogenesis; IEA:InterPro.
DR CDD; cd00819; PEPCK_GTP; 1.
DR Gene3D; 3.90.228.20; -; 1.
DR Gene3D; 3.40.449.10; Phosphoenolpyruvate Carboxykinase, domain 1; 1.
DR Gene3D; 2.170.8.10; Phosphoenolpyruvate Carboxykinase, domain 2; 1.
DR HAMAP; MF_00452; PEPCK_GTP; 1.
DR InterPro; IPR018091; PEP_carboxykin_GTP_CS.
DR InterPro; IPR013035; PEP_carboxykinase_C.
DR InterPro; IPR008209; PEP_carboxykinase_GTP.
DR InterPro; IPR035077; PEP_carboxykinase_GTP_C.
DR InterPro; IPR035078; PEP_carboxykinase_GTP_N.
DR InterPro; IPR008210; PEP_carboxykinase_N.
DR PANTHER; PTHR11561; PHOSPHOENOLPYRUVATE CARBOXYKINASE; 1.
DR PANTHER; PTHR11561:SF0; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP)-RELATED; 1.
DR Pfam; PF00821; PEPCK_GTP; 1.
DR Pfam; PF17297; PEPCK_N; 1.
DR SUPFAM; SSF68923; PEP carboxykinase N-terminal domain; 1.
DR SUPFAM; SSF53795; PEP carboxykinase-like; 1.
DR PROSITE; PS00505; PEPCK_GTP; 1.
PE 3: Inferred from homology;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000249989}.
FT DOMAIN 132..358
FT /note="Phosphoenolpyruvate carboxykinase GTP-utilising N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF17297"
FT DOMAIN 363..726
FT /note="Phosphoenolpyruvate carboxykinase C-terminal P-loop"
FT /evidence="ECO:0000259|Pfam:PF00821"
SQ SEQUENCE 730 AA; 81221 MW; E42228791AB644C8 CRC64;
MPNAIRGYRS YKEDHENNNS HRRRLRIKTA TGNPNDRSAT AVRTTTDDED EPVRCEEGEP
YQLSDATRTS LRHPSRVRIF PMTTRVPAKA SCLLPTAFGC SPKLRSLADN QIRGITIVNG
HVSQLSVKIR SYVEESVAMC LPDRIHIVDG SKQESATLIN TLHALGTVQP LPKYENCWLA
RTNPADVARV ESKTFICTQR REQAIPTAKD GIKGTLGNWI SPDDYEKAIR SRFPGCMKGR
TMYVVPFSMG PIASPLSKFG IELTDSAYVV CSMRIMTRMG LEVLEKLADN SDFIKCLHSV
GTPASGKITM PSWPCDPERT IILHKPANNE IVSYGSGYGG NSLLGKKCFA LRIGSTIAQR
EGWLAEHMLI LGITDPNGVK KYIAAAFPSA CGKTNLAMMT PTLPGYTMEC VGDDIAWMKF
DSKGQLRAIN PENGFFGVAP GTSSETNPNA MKTVYKNTIF TNVAATSDGG VFWEGMEKEI
DPEVEITDWL GQPWKMGISK TPAAHPNSRF CAPASQCPII DPAWEDNEGV PISAILFGGR
RPEGVPLVYE ANSWSHGVFI GSAMRSETTA AAEHKGKMIM NDPFAMRPFF GYNFGDYLKH
WISMEARAAA VGGQMPKIFH VNWFRKDANG KFLWPGFGEN CRVLEWVLQR VDEHECYEET
AIGRIPAKGA LNFDNLTCPI NEKELFSIPK DFWLKEVEEI KQYYDNQLPH DLPQEIAQEL
VELKSRVVQM
//
