UniProt: A0A182H019

Database: UniProt
Entry: A0A182H019_AEDAL

LinkDB:  A0A182H019_AEDAL 
Original site:  A0A182H019_AEDAL

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Ontology (5)   
   GO (5)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (5)   
   InterPro (4)   
   Pfam (1)   
Literature (1)   
   PubMed (1)   
All databases (15)   

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ID   A0A182H019_AEDAL        Unreviewed;       511 AA.
AC   A0A182H019;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   RecName: Full=Fascin {ECO:0000256|PIRNR:PIRNR005682};
GN   ORFNames=RP20_CCG019010 {ECO:0000313|EMBL:KXJ72069.1};
OS   Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7160 {ECO:0000313|EMBL:KXJ72069.1};
RN   [1] {ECO:0000313|EMBL:KXJ72069.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Foshan {ECO:0000313|EMBL:KXJ72069.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:KXJ72069.1};
RX   PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA   Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA   Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA   Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA   Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA   Yan G., Tu Z.J., Fang X., James A.A.;
RT   "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT   insights into its biology, genetics, and evolution.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN   [2] {ECO:0000313|EMBL:KXJ72069.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Foshan {ECO:0000313|EMBL:KXJ72069.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:KXJ72069.1};
RA   Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR005682}.
CC   -!- SIMILARITY: Belongs to the fascin family.
CC       {ECO:0000256|ARBA:ARBA00007415, ECO:0000256|PIRNR:PIRNR005682}.
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DR   EMBL; KQ564581; KXJ72069.1; -; Genomic_DNA.
DR   RefSeq; XP_019558776.1; XM_019703231.1.
DR   RefSeq; XP_019563223.1; XM_019707678.1.
DR   RefSeq; XP_019563224.1; XM_019707679.1.
DR   AlphaFoldDB; A0A182H019; -.
DR   STRING; 7160.A0A182H019; -.
DR   VEuPathDB; VectorBase:AALC636_021679; -.
DR   VEuPathDB; VectorBase:AALC636_027038; -.
DR   VEuPathDB; VectorBase:AALF019010; -.
DR   VEuPathDB; VectorBase:AALFPA_072141; -.
DR   Proteomes; UP000249989; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR   GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR   CDD; cd00257; Fascin; 4.
DR   Gene3D; 2.80.10.50; -; 4.
DR   InterPro; IPR008999; Actin-crosslinking.
DR   InterPro; IPR010431; Fascin.
DR   InterPro; IPR022768; Fascin-domain.
DR   InterPro; IPR024703; Fascin_metazoans.
DR   PANTHER; PTHR10551; FASCIN; 1.
DR   PANTHER; PTHR10551:SF9; PROTEIN SINGED; 1.
DR   Pfam; PF06268; Fascin; 4.
DR   PIRSF; PIRSF005682; Fascin; 1.
DR   SUPFAM; SSF50405; Actin-crosslinking proteins; 4.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW   ECO:0000256|PIRNR:PIRNR005682};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005682};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW   ECO:0000256|PIRNR:PIRNR005682};
KW   Reference proteome {ECO:0000313|Proteomes:UP000249989}.
FT   DOMAIN          34..146
FT                   /note="Fascin"
FT                   /evidence="ECO:0000259|Pfam:PF06268"
FT   DOMAIN          155..269
FT                   /note="Fascin"
FT                   /evidence="ECO:0000259|Pfam:PF06268"
FT   DOMAIN          283..391
FT                   /note="Fascin"
FT                   /evidence="ECO:0000259|Pfam:PF06268"
FT   DOMAIN          417..511
FT                   /note="Fascin"
FT                   /evidence="ECO:0000259|Pfam:PF06268"
SQ   SEQUENCE   511 AA;  57496 MW;  6D52B9B46971CF6F CRC64;
     MNGSSYEINT NGDILSQNQQ KGWWTIGLIN GQYKYMTAET FGYKLNANGA SLKKKQLWTL
     EPSNTGESII YLKSHLGRYL SVDSFGNVLC ESEERDAGSR FQISIADDNS GRWALKNEQR
     GYFLGGTPEK LTCTAKAPGR EEFWSVHLAA RPQVNLRAVG RKRFAHLSES QDEIHVDANI
     PWGEDTLFTL EFRTDEEGRY ALHTCNNKYL NSNGKLETKC TDDCLFSAEY HSGHLALRDR
     HGLYLSPIGS KAVLKSRSQT VTRDELFSLE DSLPQASFVA ALNNKYVSVK QGVDVTANQD
     EIGDNETFQL EYDWSAHRWA LRTTQDRYWC LSTGGGIQAT GNRRSADALF ELVWHGEGSV
     SFRANNGKLL ATKRSGHLFA TAEAVEDTTK FYFYLINRPI LVLKCEQGFV GYRAPGSNKL
     ECNKAIYETI LVERAPKGVV YFKGQNGKYW RIDGEGIAAD SDTPVDGFYI ELREPTRICL
     RSKDGRYLGA TKNGTFKLVD TGFDTATQWE Y
//

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