ID A0A182H0M1_AEDAL Unreviewed; 531 AA.
AC A0A182H0M1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=SRCR domain-containing protein {ECO:0000259|PROSITE:PS50287};
GN ORFNames=RP20_CCG019315 {ECO:0000313|EMBL:KXJ71944.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EnsemblMetazoa:AALF019315-PA.1, ECO:0000313|Proteomes:UP000069940};
RN [1] {ECO:0000313|EMBL:KXJ71944.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ71944.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ71944.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ71944.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ71944.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ71944.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:AALF019315-PA.1}
RP IDENTIFICATION.
RC STRAIN=Foshan {ECO:0000313|EnsemblMetazoa:AALF019315-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- COFACTOR:
CC Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC Evidence={ECO:0000256|ARBA:ARBA00001935};
CC -!- SIMILARITY: Belongs to the lysyl oxidase family.
CC {ECO:0000256|ARBA:ARBA00007492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR EMBL; JXUM01101570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01101571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01101572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01101573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KQ564658; KXJ71944.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182H0M1; -.
DR STRING; 7160.A0A182H0M1; -.
DR EnsemblMetazoa; AALF019315-RA; AALF019315-PA; AALF019315.
DR VEuPathDB; VectorBase:AALC636_001073; -.
DR VEuPathDB; VectorBase:AALF019315; -.
DR VEuPathDB; VectorBase:AALFPA_056156; -.
DR Proteomes; UP000069940; Unplaced.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0016641; F:oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; IEA:InterPro.
DR Gene3D; 3.10.250.10; SRCR-like domain; 2.
DR InterPro; IPR001695; Lysyl_oxidase.
DR InterPro; IPR019828; Lysyl_oxidase_CS.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR45817; LYSYL OXIDASE-LIKE-RELATED; 1.
DR PANTHER; PTHR45817:SF4; LYSYL OXIDASE-LIKE-RELATED; 1.
DR Pfam; PF01186; Lysyl_oxidase; 1.
DR Pfam; PF00530; SRCR; 2.
DR PRINTS; PR00074; LYSYLOXIDASE.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 2.
DR SUPFAM; SSF56487; SRCR-like; 2.
DR PROSITE; PS00926; LYSYL_OXIDASE; 1.
DR PROSITE; PS00420; SRCR_1; 1.
DR PROSITE; PS50287; SRCR_2; 2.
PE 3: Inferred from homology;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; LTQ {ECO:0000256|ARBA:ARBA00022477};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000249989};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW TPQ {ECO:0000256|ARBA:ARBA00022772}.
FT DOMAIN 81..181
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 212..319
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DISULFID 106..170
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 119..180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 150..160
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 285..295
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 531 AA; 59559 MW; B53220AF1E936394 CRC64;
MSEVSQLEFL EEEWLEEPQG LLEECQLEYP KLLGVTLVVA IAFLVSVSHA LQGSALEEAR
LHRENLVKKY LKKLKKEDGA IKLVGGRGDF EGNVEIFHDG KWGSVCDDEW DSTEAEVVCR
QLGFPGHIKA THSGFFGKAK RKFWMDNLFC GGKETELANC HFDGWGHSDC EASESAGVIC
KNDDEGGVST TPKPIPEKIK PKKVQLMKDL EVRLAGGRIP NEGRVEVRFA GSGTAWGTIC
ADGWSLLEGN VVCRQLGLGY ANDAIQTDYF GGSNRSEILL SGTECYGNET SLGNCLHHEV
GWHSSCSERG THVAAVTCVD VMADLVFDHV EMEQSLHLED RLMYLLQCAM EENCVASQAY
EIQRDNPNWH LETRRLMKFT ARVLNTGTAD FRPHIPKHLW EWHLCHMHYH SMEVFATFDI
YNGQGVKVAE GHKASFCLED NQCLPGTEPK YACANYGDQG ISVNCADIYR HNIDCQWVDI
SELDFGLYTL RVAINPEFKV PEMSYDNNAA ICSLLYTETY ARAYDCKITR P
//
