ID A0A182H0V6_AEDAL Unreviewed; 1666 AA.
AC A0A182H0V6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KXJ81496.1};
GN ORFNames=RP20_CCG019457 {ECO:0000313|EMBL:KXJ81496.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EMBL:KXJ81496.1};
RN [1] {ECO:0000313|EMBL:KXJ81496.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ81496.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ81496.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ81496.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ81496.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ81496.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; KQ560635; KXJ81496.1; -; Genomic_DNA.
DR STRING; 7160.A0A182H0V6; -.
DR VEuPathDB; VectorBase:AALC636_011358; -.
DR VEuPathDB; VectorBase:AALF019457; -.
DR VEuPathDB; VectorBase:AALFPA_050165; -.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR46513:SF36; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR Pfam; PF00058; Ldl_recept_b; 7.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS51120; LDLRB; 11.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000249989};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 135..177
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 178..223
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 224..265
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 399..441
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 442..484
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 485..529
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 530..572
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 705..747
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 748..790
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 791..832
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1098..1140
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 1306..1321
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1324..1336
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1331..1349
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1343..1358
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1666 AA; 185795 MW; 058A65FE91F4D542 CRC64;
MTNAISIIPA ARRLQRKDTH FLKCTHHHIY SCLASAFTNQ LLYTTYIDIR LANVTIQQNT
TCSVEILVKD LNEASAMDFY YDRGLVCFTE HNSETIQCAQ MRGDPGAPQA SVNKTAVITH
GLDKPEGLAI DWYTDKLYWT DGETNRIEVA TLNGKFQKVL IWSDLDQPRA IALVPARRFM
IWTDWGESPK IERASMDGDP QSRVVLVHDR IFWPNGLAVD LDNELIYWVD GNLHFLDVMN
LDGSNRRTLV NNLDYPYSLT FAPNYLFWTD WQDGTLHYYN IATEKHEEIL DSPVVPITVH
AWDSRLQPAS DNPCRRNNGD CSHLCLLSTN MAGYSCACPT GVKLLSRTQC ADGPQDMLFV
VQRTQISRIS LDSPDYTSIQ LQLGKVRYAI AIDYDPVDNY IYWSDEGSNA IKKVRPDGTG
MIEVVNTEIQ SPDGLAVDWL ARNLYWTDTG TDRIQVCRLD GSFRRVLIYE HLEEPRAIAL
APTLGWMFWS DWSEKDPKIE RASLDGTERV LIVQQNLGWP NGIALDVEAR KIYWCDAKLD
RIEVANMDGS GRNIILSDNL PHAFGLSLLG DYLYWTDWQR RSIDRANKLN GNDRTVIVEA
FPDLMGLKVA KLGDAKGNNP CAIRNGGCSQ LCLNRPRDYV CRCQIDYELD RDNRTCFIPS
AFLLFSRHDT GSIGRISIDS HNHTDYAPFR SVIDAHYLDV DIADRRIYWA SQKQKHISRA
YINGSNVEKI VESGLIQPEG IAVDWLAHNI YWTDAEARRI EVARLDGSSR RILIWKGIEE
PRNLILEPRR GLMYWAEWPS DSIRRAVMDG SELKTIISGA NLATGLTLDP DTRRLYWACQ
SSPIAIESAE WDGTKRKVLV TADSDNPFVP HAVTLYKDYV YWSDWSTGEI ERANKTTGFN
RTIVHTNLKY TNSLLAFHPF RQSGSNQCRT NNGGCSHLCL ALGQRKMTCA CPTHYTLTAN
RISCSPPKNY IIFSQRNSFG RFMPNTTDSP DVPLPVTGKN IRAVEYDVVT RYVYWIDGRG
PIIRRAFDNG TSAKVFIDPA SSPFDMVIDP IGRLLFWSCS HTNTINITTL DGEIDRIGNV
DIGNSEKPRS LALHPTKRLL FWTDVGTAQA IIRAKLDGTQ RKELVSRLEG ITALALDPLT
NRLFYAHGKR IDMMDIDGKE IKPLVTEHIS LVSSIAALNG YIYWLDERPG MERISVLGEN
RRTEIQKIPH ITDIVAVWTP EPRMLRNHTC NSVRAKCSHI CIGAPDDTKG EDVCGCPQGL
MLMKDRRSCG ALPVCGPDHF TCAVTFSSNG LDGDNNKDCI PVSWRCDGQK DCPDRSDELD
CPACGADQFK CQSGECIDKH LVCDGTMQCL DGYDEAVCCK HPEDFQCPTS KVCISYHNIC
DGDEHCANGE DEAPELCAEY NNRRMAPSGS KITMLIVVVI AVAVVFIVVY LLQTCRSRFG
AGSSEPKEDQ AAAPLSPGGL NKNIRVSKLT SVADAVRMST LNSRNSTNSY DRNHITGASS
STTNGSSLIG YPLNPPPSPA TTAGSARYSS NYHPYKHYKI INQPPPPTPC STDVCDESDS
NYTSKSARSR DRIGGMGGGG SLGGGGTSSS SGRGGTSGKY KNNSNSDRYD SEPYPPPPTP
RSHYHSDVGG MLPESCPPSP SSRSSTYFSP LPPPPSPVPS PSRGYS
//
