ID A0A182H1M1_AEDAL Unreviewed; 785 AA.
AC A0A182H1M1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Venom dipeptidyl peptidase 4 {ECO:0008006|Google:ProtNLM};
GN ORFNames=RP20_CCG019913 {ECO:0000313|EMBL:KXJ71707.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EnsemblMetazoa:AALF019913-PA.1, ECO:0000313|Proteomes:UP000069940};
RN [1] {ECO:0000313|EMBL:KXJ71707.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ71707.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ71707.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ71707.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ71707.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ71707.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:AALF019913-PA.1}
RP IDENTIFICATION.
RC STRAIN=Foshan {ECO:0000313|EnsemblMetazoa:AALF019913-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
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DR EMBL; JXUM01103618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KQ564819; KXJ71707.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182H1M1; -.
DR STRING; 7160.A0A182H1M1; -.
DR EnsemblMetazoa; AALF019913-RA; AALF019913-PA; AALF019913.
DR VEuPathDB; VectorBase:AALC636_031939; -.
DR VEuPathDB; VectorBase:AALF019913; -.
DR VEuPathDB; VectorBase:AALFPA_079285; -.
DR Proteomes; UP000069940; Unplaced.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF192; IP17501P; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000249989};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 119..488
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 577..782
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 785 AA; 87801 MW; F0115EAF81A13116 CRC64;
ELVGSKKRNT KKYLLIGGGV AIVLAVVITL VVVFTGDDSS DNGDNSPIVS GGDPITLEDF
LTGKLSARGF NGAWSPSGKV ISRDDVGRVL AYDPATNETK TLLDEQHEDL LQGFKFDLSA
DERYLLVARG YSKIFRHSFL AVYDIVDLQN NRVIPINVNG ERKALNVVEW SPVGNSFIFV
FLNNLYYKAS PDAQELQITS DGEASIYNGI PDWVYEEEVF STNLATWFST DGQKLAFIRF
NDTTTRLMKI PIYGPPGHPE FQYPHELALH YPKAGTPNPS VNLYQVDLVN PSVKTEIKPP
VALVTPENDH IITSVGWASN NRLITIWKNR VQNHAIVTTC DQNNNCGEIQ DIRVDGGWLE
LFSAPVFNKD GSQFVIIKSQ DQPDAGGYNH ITMMSTQTRS SMAFTSGKYV VQEILLWEPE
TNLIFYTANT EEDSHVLHIF AVQGHSGAKP MCLTCTVGSS PKQSYFNAQM SKKGNYIVLE
AKGPGVPWSE MFEWSFANGA VSLKPVKTLE TNTELRNRLE GKSLPTVQYH EIDLENGFTS
KVMLLIPPGA DLSGKTKYPL LVDVYGGPNS YSVTSSWSIG WGHHMSSNRS VIYAKIDGRG
SGLRGDKLLF QIYRKLGTFE IEDQITTAKK LSEKLPFVDP ARAAIWGWSY GGYASAMALA
KDANRVFKCA VSVAPVTDWT FYDSIYTERY MGLPTATDNK QGYEQSRLTA MYEKFRDRKY
MLVHGTFDDN VHYQQAMQLA RALETHDIMF KQVSYPDEDH SLAGVRPHLY HTLGRFFSEC
FDLRD
//
