ID A0A182H2E1_AEDAL Unreviewed; 598 AA.
AC A0A182H2E1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=mRNA m(6)A methyltransferase {ECO:0000256|ARBA:ARBA00012160};
DE EC=2.1.1.348 {ECO:0000256|ARBA:ARBA00012160};
GN ORFNames=RP20_CCG020342 {ECO:0000313|EMBL:KXJ71521.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EnsemblMetazoa:AALF020342-PA.1, ECO:0000313|Proteomes:UP000069940};
RN [1] {ECO:0000313|EMBL:KXJ71521.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ71521.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ71521.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ71521.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ71521.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ71521.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:AALF020342-PA.1}
RP IDENTIFICATION.
RC STRAIN=Foshan {ECO:0000313|EnsemblMetazoa:AALF020342-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-
CC methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:55584, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.348;
CC Evidence={ECO:0000256|ARBA:ARBA00036277};
CC -!- SIMILARITY: Belongs to the MT-A70-like family. {ECO:0000256|PROSITE-
CC ProRule:PRU00489}.
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DR EMBL; JXUM01105150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01105151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KQ564943; KXJ71521.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182H2E1; -.
DR STRING; 7160.A0A182H2E1; -.
DR EnsemblMetazoa; AALF020342-RA; AALF020342-PA; AALF020342.
DR VEuPathDB; VectorBase:AALC636_015940; -.
DR VEuPathDB; VectorBase:AALF020342; -.
DR VEuPathDB; VectorBase:AALFPA_057022; -.
DR OMA; NCMSPAA; -.
DR OrthoDB; 179166at2759; -.
DR Proteomes; UP000069940; Unplaced.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0016422; F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; IEA:InterPro.
DR GO; GO:0001734; F:mRNA (N6-adenosine)-methyltransferase activity; IEA:UniProt.
DR InterPro; IPR025848; MT-A70.
DR InterPro; IPR007757; MT-A70-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12829; N6-ADENOSINE-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12829:SF2; N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF05063; MT-A70; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51143; MT_A70; 1.
DR PROSITE; PS51563; SAM_MTA70L_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000249989};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 18..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 67072 MW; D982D8163F74356B CRC64;
MSSWEEIHAL KAKRNTLRER LEKRKKERQD LLGGSSPGPS VIKTEAGVAG ADDKSKILLT
AIKLEQDIDS EVEKALVKVL GDRSLILPSN SSQIAQRVEK IIQRSTANES ILVCLQKLSG
QNLVNIKEVS IGGTVGYEVI SAEYGKLQSL HDNLLLNQSE REATKRKAIK EEMDSDSKMA
RLGSGLIKEE LQKKPGESST LSSTSDIMSL LSLPSTREKQ SKQVGEEILE LLTKPTAKER
SLAEKFKSQG GAQVMEFCPH GTRIECLRSL EAANDALLKS EDDDDVIITR IEPGSNGNNG
FEIVEIKKEK DDDKIKFQCN KLHFKKIIQS HTDESLGDCS FLNTCFHMDT CKYVHYEVDT
YVGQNTGSKF EGEVSKRTID PCATLYPPQW IQCDLRYLDM TVLGKFAVVM ADPPWDIHME
LPYGTMSDDE MRQLGVPALQ DDGLIFLWVT GRAMELGREC LKLWGYERVD ELIWVKTNQL
QRIIRTGRTG HWLNHGKEHC LVGMKGNPPN LNRGLDCDVI VAEVRATSHK PDEIYGIIER
LSPGTRKIEL FGRPHNVQPN WITLGNQLDG IRLVDPELIS SFQKRYPDGN CMTPGKNP
//