ID A0A182H3F9_AEDAL Unreviewed; 628 AA.
AC A0A182H3F9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein {ECO:0000259|PROSITE:PS00623, ECO:0000259|PROSITE:PS00624};
GN ORFNames=RP20_CCG020917 {ECO:0000313|EMBL:KXJ81243.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EnsemblMetazoa:AALF020917-PA.1, ECO:0000313|Proteomes:UP000069940};
RN [1] {ECO:0000313|EMBL:KXJ81243.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ81243.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ81243.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ81243.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ81243.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ81243.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:AALF020917-PA.1}
RP IDENTIFICATION.
RC STRAIN=Foshan {ECO:0000313|EnsemblMetazoa:AALF020917-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|RuleBase:RU003968}.
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DR EMBL; JXUM01024565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KQ560694; KXJ81243.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182H3F9; -.
DR STRING; 7160.A0A182H3F9; -.
DR EnsemblMetazoa; AALF020917-RA; AALF020917-PA; AALF020917.
DR VEuPathDB; VectorBase:AALC636_011825; -.
DR VEuPathDB; VectorBase:AALF020917; -.
DR VEuPathDB; VectorBase:AALFPA_056670; -.
DR Proteomes; UP000069940; Unplaced.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF208; GLUCOSE DEHYDROGENASE [FAD, QUINONE]-LIKE PROTEIN; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00623; GMC_OXRED_1; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR000137-2, ECO:0000256|RuleBase:RU003968};
KW Flavoprotein {ECO:0000256|RuleBase:RU003968};
KW Reference proteome {ECO:0000313|Proteomes:UP000249989}.
FT DOMAIN 143..166
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00623"
FT DOMAIN 320..334
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT BINDING 283
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 628 AA; 69284 MW; 02D173326D2155D1 CRC64;
MALSVKLCVL AIAIGILCIG SGDAFFFLLK SLAHIGRYDD GYDDQYNYVQ PTYGNPQVKE
IPEYDFIIVG AGPAGCVLAN RLSENSRWKV LLLEAGPGEN ELNNIPILTT FLQNSQYNWA
DVAEAQNDSC WGMIDQRCSI PHGKGLGGST LINYMMYTRG NPADYDRWAS MGNPGWSYSD
VYPYFLKTER ASLRGLENSS YHGYDGELSV EFPPFRTDLA RTFVKGAREI GHKKIDYNGK
GQLGVSYVQT NTINGMRQTA YRALIQPILA NRPNLHVKAY SRVIKVLINP NTKSAYGVTY
TKNFRNFDIH ARKEVIVTAG AINTPQLLML SGVGPEDTLQ DIKVPVVQNL PVGQNMIDSI
VFNGLTFVLN ETGHALLTDS RFQLNSIADY FNGQGPLTVP GGVEAVDFLQ TSRAEQPGVP
DIAVIFSTGS LVSDGGLGLR SGKRIKTSLY NKVYKPLETL PNDQWTATVS LLHPKSRGFI
KLRNANPFNS PKIYTNYLTE DNDVETLLEG IKEAVRLSKS PSMKRYDARV LGIPLPNCKQ
YEISSDDYWR CAIRTLSSTA YQQLGTCKMG PHGDPTAVVS AELEVHGVEN LRVADVSVVP
TTISGHSAAI DYMIGEKAAD LIKQRWAM
//
