ID A0A182H564_AEDAL Unreviewed; 921 AA.
AC A0A182H564;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Staphylococcal nuclease domain-containing protein {ECO:0000256|PIRNR:PIRNR017179};
DE EC=3.1.31.1 {ECO:0000256|PIRNR:PIRNR017179};
GN ORFNames=RP20_CCG021925 {ECO:0000313|EMBL:KXJ70956.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EMBL:KXJ70956.1};
RN [1] {ECO:0000313|EMBL:KXJ70956.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ70956.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ70956.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ70956.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ70956.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ70956.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endonuclease that mediates miRNA decay of both protein-free
CC and AGO2-loaded miRNAs. {ECO:0000256|PIRNR:PIRNR017179}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-
CC phosphooligonucleotide end-products.; EC=3.1.31.1;
CC Evidence={ECO:0000256|PIRNR:PIRNR017179};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR017179}.
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DR EMBL; KQ565451; KXJ70956.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182H564; -.
DR STRING; 7160.A0A182H564; -.
DR VEuPathDB; VectorBase:AALC636_022430; -.
DR VEuPathDB; VectorBase:AALF021925; -.
DR VEuPathDB; VectorBase:AALFPA_043385; -.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016442; C:RISC complex; IEA:UniProtKB-UniRule.
DR GO; GO:0016894; F:endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters; IEA:UniProtKB-EC.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:InterPro.
DR CDD; cd00175; SNc; 2.
DR CDD; cd20433; Tudor_TDRD11; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.50.90; -; 5.
DR InterPro; IPR016685; Silence_cplx_Nase-comp_TudorSN.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047386; Tudor_TDRD11.
DR PANTHER; PTHR12302; EBNA2 BINDING PROTEIN P100; 1.
DR PANTHER; PTHR12302:SF2; STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00565; SNase; 4.
DR Pfam; PF00567; TUDOR; 1.
DR PIRSF; PIRSF017179; RISC-Tudor-SN; 1.
DR SMART; SM00318; SNc; 4.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF50199; Staphylococcal nuclease; 5.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50830; TNASE_3; 4.
DR PROSITE; PS50304; TUDOR; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR017179};
KW Reference proteome {ECO:0000313|Proteomes:UP000249989};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ SEQUENCE 921 AA; 103387 MW; EA02F68224C1120C CRC64;
MSAAPAAAAP APAPVLKRGI VKQVLSGDSV IIRGQPKGGP PPEKQINFSG VIAPKLARRP
TNNSTEITKD EPYAWEAREY LRQRLIGQEV YFYAERPPNA TRDYGYVCLG KDPATSENIV
ESIVSEGLVS VRREGVRQTP ELTRLCELED AAKAARKGKW SDSPSSDHVR NITWNIENPK
AFFDHHDGKP IKAIIEHVRD GSTVRAFLLP EFQHVTLMMS GIRCPGFKLD LDGKPDATAE
VPFAEEARYF VESRLLQREV EIRLESVNNS NFVGTIIFPK GNIAEALLKE GFAKCVEWSM
PYVKEGVDRL RAAEKHAKAN RLRLWKDYQA PTAAYNSKDK DFTGNVVEVF NGDAIMVKIS
NTVSKKVFLS SIKPPREAAR TADEEGNLPP RPKGSRPLYD VPWMFEAREF LRKKLIGKKV
HCSLDYVTPA RDNFPEKCCY TVTLSGANVA EALVAKGLAT VIKYRQDDDQ RSLHYDELRS
AETQAMKQLK GVHAKDDIPS HRINDLTVDH SRIKHQYLPS WQRALRTEAI VEFVASGSRF
RIYCPKDSCL VTFLLAGISC PRSSRPALSG VPAQEGEPFG DDALQFSKER ILQRDVSVKI
ETTDKAATSV IGWLWTENNV NLSVALVEEG LASVHFTAEK TEHYRALSEA EARAKAKRKN
IWKDYVEKVE EDNKENEDEK DDPAAPADRK VKYENVVVTE VTPELHFYAQ HADQGAKLEE
LMTKLRQEFR AMPPVTGAYN PRRGDMCAAK FSEDNEWYRA KVEKIEKGGN ASILYVDYGN
RETVPTTRLA MLPPAFVSDK PYAHEYSLAL VVLPTDEEDK ADALKAFAQD ALNKTLQMNV
EYRVSGAEHV TLVDPATKAD LGKELINDGF LIAEKNKKDR RLQKLINDYK EAEQSARKNR
NGIWQYGDST EDQAGEFGLS R
//
