ID A0A182H869_AEDAL Unreviewed; 890 AA.
AC A0A182H869;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN ORFNames=RP20_CCG023842 {ECO:0000313|EMBL:KXJ80681.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EnsemblMetazoa:AALF023842-PA.1, ECO:0000313|Proteomes:UP000069940};
RN [1] {ECO:0000313|EMBL:KXJ80681.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ80681.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ80681.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ80681.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ80681.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ80681.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:AALF023842-PA.1}
RP IDENTIFICATION.
RC STRAIN=Foshan {ECO:0000313|EnsemblMetazoa:AALF023842-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
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DR EMBL; JXUM01028836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KQ560833; KXJ80681.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182H869; -.
DR STRING; 7160.A0A182H869; -.
DR EnsemblMetazoa; AALF023842-RA; AALF023842-PA; AALF023842.
DR VEuPathDB; VectorBase:AALF023842; -.
DR VEuPathDB; VectorBase:AALFPA_052917; -.
DR Proteomes; UP000069940; Unplaced.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProt.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR36688; ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR36688:SF1; ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF14529; Exo_endo_phos_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000249989};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT DOMAIN 490..761
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 890 AA; 101201 MW; 13B08A0B0818DA1D CRC64;
MTNHHCLRVV NWNGRSVHSK QLEFFDFVQQ RNIDVAVVTE TWLRPNISFL HPDFACVRLD
RPPSDEVGRG GGVLIAVRKG LSFKQINIST KTIETTGIVI STGVNQICIV AAYFPGGRRC
SDWTQFRRDI RTMTNHDVPF FITGDLNARH RYWNCAKSNK AGNILFQEAA QTGLNIHFPD
SPTFVPSGRG NPSTLDIVLS NNLVNMSKPI TLNELSSDHL PVCFEISLSA IPETITSTVR
CYARANWPAF QRVVNARLDP IDPLFANIQD EDGVNAAVRC FKEVLLDAES IAVPAIAPRP
YEVARLPDET KLLIQLRNRR RRQWMRTRDP MLKNIVLALN DRIRTDCANA RFSKFADTLV
SMERGDNKIW RITKALKNTN KYSPPLRSGD TLVACPKDKA QLLAESFSLA HNNQCVDDRN
TAEAVERSVE QIDQSPSTAD NSWLVRPKEI ANIIRNLKNK KAPGHDGVKN WLLKHLPRKG
YVVLSKIFSA CFKLSYFPND WKHAIVVAIP KANKDTSVPT NYRPISLLPT LSKVFERVIL
TRIEKHLEVT RIIPNEQFGF QKGHSTSHQI VRLVKEVRRN FHQGKSSGLI LLDVEKAYDS
VWHGAILHKM LLGNFSMLIL KMIRSFLKDR TFQVSVNGST SDRKPVPFGV PQGSVLSPTL
YNIFSADIVK INGVEYYFFA DDTGFLVSHH DPAVVVDTLQ EAQNSIQEYQ RKWKVKVNPA
KSQAIFFTRR RSPRHLPQSQ VSCGGVDIPW SQNVGYLGMT LDPKLKFGCH VANCLQKCDK
LTKMLYPLVK RRSRLDRNLK VLLYKTVFRP TVAYGFPVWY DCAQSHRNKI QVKQNRLLKM
MLDLSPFHPT EEVHRLAGVE KIDDWFRRLI PKFLQSCASS VNPLLQELAV
//
