ID A0A182HBR2_AEDAL Unreviewed; 543 AA.
AC A0A182HBR2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Kelch-like protein diablo {ECO:0000256|ARBA:ARBA00013699};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EnsemblMetazoa:AALF026098-PA.1, ECO:0000313|Proteomes:UP000069940};
RN [1] {ECO:0000313|EnsemblMetazoa:AALF026098-PA.1}
RP IDENTIFICATION.
RC STRAIN=Foshan {ECO:0000313|EnsemblMetazoa:AALF026098-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex which mediates the ubiquitination and subsequent
CC proteasomal degradation of target proteins. May have a role in synapse
CC differentiation and growth. {ECO:0000256|ARBA:ARBA00043912}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JXUM01032288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JXUM01032289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182HBR2; -.
DR EnsemblMetazoa; AALF026098-RA; AALF026098-PA; AALF026098.
DR VEuPathDB; VectorBase:AALC636_012113; -.
DR VEuPathDB; VectorBase:AALF026098; -.
DR VEuPathDB; VectorBase:AALFPA_045395; -.
DR Proteomes; UP000069940; Unplaced.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412:SF35; ACTIN-BINDING PROTEIN IPP; 1.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; Kelch motif; 2.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
SQ SEQUENCE 543 AA; 59512 MW; 0EB6E0478DF6379A CRC64;
MFTGHLRESQ QEEITLQEVS GEALQLLIQY CYTGTIELRE DTVETLLATA CLLQLSTIVN
ACCTFLARQL HPSNCLGFSL FAEQQGCTAL LKIASAYTCQ HFMQVWKNQE FFQLDSMQLS
TLLKSDDLNV PNEQEVFHAL MAWIQFEPET RKQYIPELLA LIRLPLLQPS FIVDHVEALC
GANECQQLVM EAFKWHLIPG RRSQISTQRT RPRKSTIGKL LAVGGMDGHK GAISIESYEP
RLDKWTLLKN MPARRLQFGV AVMDDKLIIV GGRDGLKTLN TVECFDLTTM TWGSIVPPMG
TPRHGLGVAF LEGPLYAVGG HDGWSYLATV ERWDPAARTW SYVAPMSSMR STAGVAVLNS
RLFVIGGRDG SVCHRTVECY DPHTNKWTLR APMNKRRGGV GVGVLNGYLY ALGGHDCPAS
NPAVCRTETV ERYDPTTDTW TLIASLSVGR DAIGVSVLGD WLIAVGGYDG NQYLKTVEQY
DTESNEWQQI APVNYSRAGA CVVAIPNNFS PASGTSAVAT SGPSVASIAG ALVSSSSSTN
TTV
//
