ID A0A182HF12_AEDAL Unreviewed; 1629 AA.
AC A0A182HF12;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=RP20_CCG028267 {ECO:0000313|EMBL:KXJ69220.1};
OS Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7160 {ECO:0000313|EMBL:KXJ69220.1};
RN [1] {ECO:0000313|EMBL:KXJ69220.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ69220.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ69220.1};
RX PubMed=26483478; DOI=10.1073/pnas.1516410112;
RA Chen X.G., Jiang X., Gu J., Xu M., Wu Y., Deng Y., Zhang C., Bonizzoni M.,
RA Dermauw W., Vontas J., Armbruster P., Huang X., Yang Y., Zhang H., He W.,
RA Peng H., Liu Y., Wu K., Chen J., Lirakis M., Topalis P., Van Leeuwen T.,
RA Hall A.B., Jiang X., Thorpe C., Mueller R.L., Sun C., Waterhouse R.M.,
RA Yan G., Tu Z.J., Fang X., James A.A.;
RT "Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals
RT insights into its biology, genetics, and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:E5907-E5915(2015).
RN [2] {ECO:0000313|EMBL:KXJ69220.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Foshan {ECO:0000313|EMBL:KXJ69220.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:KXJ69220.1};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; KQ567940; KXJ69220.1; -; Genomic_DNA.
DR STRING; 7160.A0A182HF12; -.
DR VEuPathDB; VectorBase:AALC636_038282; -.
DR VEuPathDB; VectorBase:AALF028267; -.
DR VEuPathDB; VectorBase:AALFPA_066889; -.
DR Proteomes; UP000249989; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd18018; DEXHc_RecQ4-like; 1.
DR CDD; cd22289; RecQL4_SLD2_NTD; 1.
DR Gene3D; 1.10.10.1460; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR021110; DNA_rep_checkpnt_protein.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001878; Znf_CCHC.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF108; ATP-DEPENDENT DNA HELICASE Q4; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF11719; Drc1-Sld2; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000249989}.
SQ SEQUENCE 1629 AA; 180327 MW; F621F06A4E2922FF CRC64;
MEDPVFRTKY RKYKFIVKNW ERKFRKQHGR IPSKHDIRDS TVDVRNAYKM YYKLKTSLLE
DTLQDALLDD DDFDSSLISQ MEGTLSQDCS IGAFSNLSDL SSANVSISAL LTDQIDGRVT
EFEAVEQSEQ NANAWNLPRR KADVPEEPKE QPASKPKAKA PTKLMMEASA VIPKRNPRKS
LSSLRLSQSG SSFSSPSMAS WKDSLPDLET LLYEKSKQSV EVSPSQEQCS QKQSASGNES
QLDSKGLVNE LDERWLTRQG MDAGSLTPVS SASGQAKKFG LRNISGISVS DVSAPVDTSN
SFGISSLSMT SFASEAPGSE LEQSNQTQQV VSAQNTAYDR AIQSDSDGVV ENSEDEATSA
NSSFNTSGAI RHVAKKRKVF TSVNLKVDPK VNQAVVVVAS DSMKAVPIEV PPVEVGIGVE
NKDPEIKGDL PIESDEPKTK RARKKAPAKA KAKKTVQPKK VPVRRTTRGR KPVQYTQHAG
SEEETGDFDP DDEDKDPDFK EQAEETRSLH DEEEQEHQME QTVPEDTVST AKPARKTIAA
RKSRAKQPAA SAGERKRRSG STKKSPSAPR IGGNTGKGKK RVARQPAAKV VPSKEEAAKE
DGFDDYVLEF GIESLNNAPR VDIKELIKST QAVESFIQGV PLKAAKSAKK LDEDEVVTAK
EAAFRKKVAA GKQNENFVRL DLRKKVFARG KKTMNFSKYK KNLWKKKKAA ALCGPDMDMG
GCDGGVLTCF QCGGVGHMAR QCKVKGEQLL PLDVDATEES PFPTLDEVET MAKAQSLAVH
SNKIDKLPAV SNPLWKLDDT ESTPDLEADS EYEDLPEEPA VPAETKPSYI GHVIPQDFLK
KSGILELTVS NKDKIGPLYQ LNPDGSLPAT PKAVFDALKM FGHQQFRSGQ ERAVMRVLCG
MSTLVTLSTG SGKSLCYQLP AYLYRKHRKC VTLVISPLVS LMEDQVHGVP DFLNAQCLHM
NQSPKVRART MDAITNGELD VLLISPEAVV SGEKSTGFGS LLRQLPPIAF ACIDEAHCVS
QWSHNFRPSY LMICRVLKEK LGVQTILGLT ATATVQTRLS IVEHLAVPDG TNGIISDIPL
PDNLILTVSK DANRDSALLN LLQSNRFAEL HSIIIYCTRR DECERIASFL RTCFQDAQRA
AEAKAAASAT ASRKRKKLNY TAEPYHAGLS SARRRTIQNA FMSGELRIVV ATIAFGMGIN
KADIRAIIHY NMPRNFESYV QEVGRAGRDG GASHCHVFLD NRGKDRNELR RHIYANSIDR
HVIRKLLQKI FVPCACVRNF KDEKFSEEHR KQIEALKDIS WTDDFEETTQ ANPSTSAASP
VKSKRVCPGH EACFSIESTV QQLDIPEENI ETLLCYLELH EQRYIHVLSK AYVMCKVMSY
AGPKALRNAA KNCPPLAMAI ALELKKGNAE ASSTFIEFPV IDVASAIGWD SGVVKFQLKN
LEWTIENNTR TRTPISVSFS DLGFRIRAPG DLTDDELDKT LDTLYARVSG QERAQLVQLQ
CISNALSSVA FQTYLPVSGA ECPDGPSGKL KTIVRQYFQT DISNEEVELM PELDDTPDAQ
LLNDIRTLIH RYPQNNFSGR AVARIFHGVQ SPNYPAVIWF RCQFWRAHTC VDFNRIVRMA
NAELVRMQT
//
