ID A0A182HFN9_ANOAR Unreviewed; 134 AA.
AC A0A182HFN9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Insulin-like domain-containing protein {ECO:0000259|SMART:SM00078};
OS Anopheles arabiensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA000037-PA.2, ECO:0000313|Proteomes:UP000075840};
RN [1] {ECO:0000313|Proteomes:UP000075840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AARA000037-PA.2}
RP IDENTIFICATION.
RC STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA000037-PA.2};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds. {ECO:0000256|ARBA:ARBA00011207}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; APCN01005548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182HFN9; -.
DR EnsemblMetazoa; AARA000037-RA; AARA000037-PA; AARA000037.
DR VEuPathDB; VectorBase:AARA000037; -.
DR VEuPathDB; VectorBase:AARA21_009511; -.
DR OrthoDB; 3028803at2759; -.
DR Proteomes; UP000075840; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd04366; IlGF_insulin_bombyxin_like; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR040228; Insulin-relat-peptide_inver.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR13647; INSULIN-LIKE PEPTIDE 2-RELATED; 1.
DR PANTHER; PTHR13647:SF6; INSULIN-LIKE PEPTIDE 2-RELATED; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Secreted {ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 44..133
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
SQ SEQUENCE 134 AA; 14934 MW; AA310BA51F4DDF8D CRC64;
MRSSAVGMSS VLIVAVVVVL LMLNETHATS TPNSDALISQ LTRSRYCGRR LTETLAFLCQ
GRYPMLTHYR TDYVHDQANQ RVKVEVATLP DTLPPGFPYP GAGVHRRSRR SSGGIYDECC
KKSCSYVELR AYCD
//
