GenomeNet

Database: UniProt
Entry: A0A182HH42_ANOAR
LinkDB: A0A182HH42_ANOAR
Original site: A0A182HH42_ANOAR 
ID   A0A182HH42_ANOAR        Unreviewed;      1093 AA.
AC   A0A182HH42;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   03-JUL-2019, entry version 19.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
OS   Anopheles arabiensis (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=7173 {ECO:0000313|Proteomes:UP000075840, ECO:0000313|VectorBase:AARA000545-PA};
RN   [1] {ECO:0000313|VectorBase:AARA000545-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dongola {ECO:0000313|VectorBase:AARA000545-PA};
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000075840}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S.,
RA   Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|VectorBase:AARA000545-PA}
RP   IDENTIFICATION.
RC   STRAIN=Dongola {ECO:0000313|VectorBase:AARA000545-PA};
RG   VectorBase;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; APCN01002384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   VectorBase; AARA000545-RA; AARA000545-PA; AARA000545.
DR   Proteomes; UP000075840; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000075840};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000075840};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      116    466       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      531    960       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      998   1071       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     34       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A182HH42}.
FT   COMPBIAS      1     16       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A182HH42}.
SQ   SEQUENCE   1093 AA;  123482 MW;  11B4674377C371FC CRC64;
     MNTKRKPFTK PNEAASSSGP KKFRGGDDEE EEFESYFEAE LANLDDDADT ARIGLGPESE
     NTCAKWSRPA PAPLDPARDA LVFQQIDIDN YIGQPMAGMP GAQVGPVPVM RMFGVTMEGN
     SVCAHVHGFL PYLYVAAPRG FSKAHLQEFR AALDKAVLHD MRTNKDNVQE AVLEVELVER
     QSIMGYNGED LFTFIRVTVA LPKLLAAVKR LLEREQLMPS MDFQDCRVYE SNIDFDIRFM
     VDTGVVGCSW IELPAGSWTA RRKGVQPVPE TRCQLEVDVA FNAFVAHDPE GEWAKVAPFR
     ILSFDIECAG RKGIFPEPQH DPVIQIANMV IRQGEQEPFL RNVFTLNTCA PIVGAQVLSH
     KTEQELLDRW ACFVRELDPD ILTGYNINNF DVPYLLNRAN HLKVRNFEYL GRVTNIRSVI
     KDTVIQSKQM GRRENKFVNF EGRVPFDLLF VLLRDYKLRS YTLNAVSYHF LQEQKEDVHH
     SIITDLQNES EQTRRRLAMY CLKDAYLPLR LLNKLMCIVN YMEMARVTGV PLACLLTRGQ
     QIKVMSQLLR KSRVAGYLIP SYQSSGSEEQ YEGATVIEPK RGYYANPIST LDFASLYPSI
     MMAHNLCYTT LVQPNMKDKL GLSPDQLTHT PANNVFVKAS VRKGILPEIL ESLLAARKRA
     KADLKVETDP FKRSVLDGRQ LALKISANSV YGFTGAQVGK LPCLEISGSV TAYGRTMIEQ
     TKQEVEQRYT VEHGYENDAV VIYGDTDSVM VNFGVKTLER SMELGKEAAD YVSAKFVKPI
     KLEFEKVYYP YLLINKKRYA GLYFTRPDRY DKMDCKGIET VRRDNSPLVA NLMNSCLQKL
     LIERNPDGAI EYAKQTIADL LCNRIDISQL VITKELAKSD YAAKQAHVEL ANKMKKRDPG
     NAPKLGDRVP YVLIAAAKNT PAYMKAEDPI YVLENCVPID ANYYLENQLS KPLLRIFEPI
     LGEKAESILL RGDHTRTRAV VTSKVGALAA FTKKRDACLG CKALLAVGQE GKALCPHCTP
     NEASLYQGEL AAQRTLEERF CRLWTECQRC QGSLHEEVIC TSRDCPIFYM RTKIKMELET
     QEKRVARFGV PAW
//
DBGET integrated database retrieval system