ID A0A182HHM1_ANOAR Unreviewed; 1213 AA.
AC A0A182HHM1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
OS Anopheles arabiensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA000724-PA.1, ECO:0000313|Proteomes:UP000075840};
RN [1] {ECO:0000313|Proteomes:UP000075840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AARA000724-PA.1}
RP IDENTIFICATION.
RC STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA000724-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; APCN01002428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182HHM1; -.
DR EnsemblMetazoa; AARA000724-RA; AARA000724-PA; AARA000724.
DR VEuPathDB; VectorBase:AARA000724; -.
DR VEuPathDB; VectorBase:AARA21_012960; -.
DR OrthoDB; 45541at2759; -.
DR Proteomes; UP000075840; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd16724; RING-HC_MIB1_rpt1; 1.
DR CDD; cd16725; RING-HC_MIB1_rpt2; 1.
DR CDD; cd16727; RING-HC_MIB1_rpt3; 1.
DR CDD; cd02339; ZZ_Mind_bomb; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR042056; MIB1/2_ZZ.
DR InterPro; IPR010606; Mib_Herc2.
DR InterPro; IPR037252; Mib_Herc2_sf.
DR InterPro; IPR040847; SH3_15.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR24202:SF53; E3 UBIQUITIN-PROTEIN LIGASE MIB1-RELATED; 1.
DR PANTHER; PTHR24202; E3 UBIQUITIN-PROTEIN LIGASE MIB2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13606; Ank_3; 1.
DR Pfam; PF06701; MIB_HERC2; 2.
DR Pfam; PF18346; SH3_15; 2.
DR Pfam; PF13920; zf-C3HC4_3; 3.
DR Pfam; PF00569; ZZ; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 8.
DR SMART; SM00184; RING; 3.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF159034; Mib/herc2 domain-like; 2.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS51416; MIB_HERC2; 2.
DR PROSITE; PS50089; ZF_RING_2; 3.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ SEQUENCE 1213 AA; 130117 MW; F1D48A892C2552CD CRC64;
MACASTSSTA SMELVGPAGP TNVAAAARPS RFTMEGVGSR VIRGPDWKWG KQDGGEGHVG
TVRNFESQEE VVVVWDNGTA ANYRCAGAYD LRILDSAPTG IKHEGTMCDT CRQQPIFGIR
WKCAECNNYD LCSICYQSDK HHLRHRFHRI TTPGGEKTLL EPRRKSKKIA VRGIFPGARV
VRGVDWQWED QDGGNGRRGK VNEVQDWSSA SPRSAAYVVW DNGAKNLYRV GFEGMADLKV
VNDAKGMTVY RDHLPLLGEY GPGRAPNNFQ IGDQVTVDLD IEIVQSLQHG HGGWTDGMFE
CLSTTGTVVG IDEDHDIVVA YPSSHRWTFN PTVLTIVSSP MMLLADNQPQ QFAVGDFVKI
CSDLERIKIL QRGHGEWAEA MVPTLGKVGR VQQVYHDNDL KVEVCNTSWT YNPLAVTKVA
SSSDGATAVT TNGERLSAIL KKLFEPHASG DTTEELVKAA ANGDKAKVEE FLIGSAGGQN
VAPSSSSAAG AAASLGESQS VVKVDVNGVF AGHTALQAAS QNGHLEVIEV LLRHNADVEI
EDKDGDRAVH HAAFGDEPGV MGMLAKAGAD LNARNKRRQT ALHIAVNKGH FNVVKTLLEL
NCHPSLQDSE GDTALHDAIS KEHDNMLALL LDNGADITLT NNNGFNALHH AALKGNPSAM
KVLLTKTNRL WIVEEKKDDG YTALHLAALN NHVEIAELLV RMGKANMDCQ NVNLQTALHL
AVERQHVQIV KLLVREGANL NIPDKDGDTP LHEALRHHTL SQLRQLQDVE GFGKILMGLR
NNTDKKASAS IACFLAANGA DLTIKNRKLQ TPLDLCPDPN LCKTLIKCYN ERKTEDMDSM
TLGMASHTGG GGGPTMPLRR GGYRPPDEPI ASTSAGNPGT SGLGSGGLNH AQIDANLLMG
LSKMSIQPNA AGEANTNVSV NHNTASSGGG GGVSVACSVA TTTAGDSSGP LDECLLCSDQ
KRDTVFKPCG HVVCCENCGP RIKKCLICRE SVLSREKIDE CLVCSDRKAS VFFKPCGHMV
ACEHCAPIMK KCVQCRTQLE QMVPLSVCSG GQGSVINIQH PVEDGKKDLL HNHNASQQQQ
QQLLQGTNKA GLGVAMNNTM SPNASALAAG SGSGGVALGN NGQAVGGASS STGSSNTNAS
LIVSPNNLNL VDDFQKLQQQ LQDIKEQTMC PVCFDRIKNM VFLCGHGTCQ MCGDQIDGCP
ICRKTVEKRI LLF
//
