ID   A0A182HIL3_ANOAR        Unreviewed;       510 AA.
AC   A0A182HIL3;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=Serine/threonine-protein kinase ULK3 {ECO:0000256|ARBA:ARBA00021644};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE   AltName: Full=Unc-51-like kinase 3 {ECO:0000256|ARBA:ARBA00032242};
OS   Anopheles arabiensis (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA001073-PA.1, ECO:0000313|Proteomes:UP000075840};
RN   [1] {ECO:0000313|Proteomes:UP000075840}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AARA001073-PA.1}
RP   IDENTIFICATION.
RC   STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA001073-PA.1};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; APCN01004001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A182HIL3; -.
DR   EnsemblMetazoa; AARA001073-RA; AARA001073-PA; AARA001073.
DR   VEuPathDB; VectorBase:AARA001073; -.
DR   VEuPathDB; VectorBase:AARA21_006358; -.
DR   OrthoDB; 8335at2759; -.
DR   Proteomes; UP000075840; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR   CDD; cd14121; STKc_ULK3; 1.
DR   Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 2.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR045269; Atg1-like.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR007330; MIT_dom.
DR   InterPro; IPR036181; MIT_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR24348; SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED; 1.
DR   PANTHER; PTHR24348:SF65; SERINE_THREONINE-PROTEIN KINASE ULK3; 1.
DR   Pfam; PF04212; MIT; 2.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00745; MIT; 2.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF116846; MIT domain; 2.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
SQ   SEQUENCE   510 AA;  57292 MW;  FBB9589AA8B6E1AA CRC64;
     MSEAKITEYK LLERLGSGTY AIVYRAMKKT TKEILAVKVM AKSKLSCTAM DNIISEISLL
     KKLKHRHIVE MRDFLWDEEN IYILMEYCDA GNLSSYIRQH RTLDEGTCKR FLQQLALALR
     YMRQHDVSHL DLKPANLLLT RASGTYVLKV GDFGFAQRLK LNQENTAVKG SPLYMAPEIL
     LNSSYGPAAD LWSVGVILYE CLFGRAPYSS TSLHELAERI HRNDPIAIPC RPAISTDCRQ
     LLVSLLQRDP GRRIGFEKFF DDPYLDLAHV ACEENLEKAI ALINRAIELE QRQELAGAYR
     AYCQGLQYFV PITRAEPDAG KRQLLRQRVL TYLNRAEALK QHIYATTQTE QQQQQQQQQD
     VPAASVLKRP DEKGRSGAGN IHSSSSSKEG TGGGGGGRSS DTLVEKAHEP GIAELARDNE
     AIARGLEIGW QAAKEASENK LDAALDSYTS ALSLLIPVLH QDIPAGQKRV LRQRVVQWME
     EAEQIKSIRS AQIMQEMEST EANHYACTVQ
//