ID A0A182HL33_ANOAR Unreviewed; 2174 AA.
AC A0A182HL33;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=U5 small nuclear ribonucleoprotein 200 kDa helicase {ECO:0000256|ARBA:ARBA00034541};
OS Anopheles arabiensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA001963-PA.1, ECO:0000313|Proteomes:UP000075840};
RN [1] {ECO:0000313|Proteomes:UP000075840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AARA001963-PA.1}
RP IDENTIFICATION.
RC STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA001963-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
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DR EMBL; APCN01000879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EnsemblMetazoa; AARA001963-RA; AARA001963-PA; AARA001963.
DR VEuPathDB; VectorBase:AARA001963; -.
DR VEuPathDB; VectorBase:AARA21_010568; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000075840; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18019; DEXHc_Brr2_1; 1.
DR CDD; cd18021; DEXHc_Brr2_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
SQ SEQUENCE 2174 AA; 246978 MW; 5C6CA35F4509E1EE CRC64;
MADAAARQLQ YEYKANSNLV LQADVRLIER PRRDEATGEV ISLVGKLDGT RMGDRAQRSK
PEKTEERKAK RQKRDEAQYD FNSMKGATLL SEGIDEMVGI VYRPKTQETR QTYEVLLSFI
QEAIGDQPRD ILRGAADEIL AVLKNDRMKE REKKREIDGL LGSVADERFA LLVNLGKKIT
DFGSDAATAI GGAGQAGPGG DEPIDETYGI NVRFEESEEE SDEDKYGEVR EDDGQDEGEE
ARDDGILHAE NLGGGEDMNK KEKALDPRDI DAHWLQRCLR KYYNDSMMSQ AKALEVLSVL
KESGDDRECE NQLVLLLGYD CFDFIKQLKK NRQMILYCTM LAQSQSESDR AKLRDRMKSD
AALAKILRQL DTGKQEAQEA RDYANGGGAD GSDSKTSLRS RRERAMDEGA MDDMDVHVGG
AAERTAPVGG TILGNRTVLE LDELAFTQGS HLMANKRCQL PDGSFRKQRK GYEEVHVPAL
KPRPFDEDEE LIAIEKLPKY VQPVFNGFKT LNRIQSRLYK SALESDENLL LCAPTGAGKT
NVALLTMMRE IGKHINDDGT INVDEFKIIY IAPMRSLVQE MVGNFGRRLA TYNLTVAELT
GDHQLSREQI AATQVIVCTP EKWDIITRKG GEKTYTQFVR LVIIDEIHLL HDERGPVLEA
LVARTIRNIE TTQEDVRLVG LSATLPNYQD VSTFLRVRPE TGLFYFDNSY RPVALEQQYI
GVTEKKALKR FQVMNDIVYE KVMEHAGRNQ VLVFVHSRKE TGKTARAIRD MCLEKDTLGT
FLRDGSASME VLRSEAEQVK NQELKDLLPY GFAIHHAGMT RVDRTLVEDL FADRHIQVLV
STATLAWGVN LPAHTVIIKG TQVYNPEKGR WVELGALDVL QMLGRAGRPQ YDTKGEGILI
TNHSELQYYL SLLNQQLPIE SQLISKLPDM LNAEIVLGTV QNVKDAVTWL GYTYLYIRML
RQPTLYGVSI DAVKEDPLLE QFRADLIHTA ALHLERSGLI KYDRKSGHLQ VTEVGRIASH
YYCTHDTMLT YHQLLKPTLS EIELFRVFSL SGEFRNITVR EEEKLELQKL MERVPIPIKE
SMEEPSAKVN VLLQAYISQL KLEGFALMAD MVYVTQSASR LLRAIFEIVL HRGWAQLADK
CLTLCKMIDR RMWQSMSPLR QFRKMPEEIV KKIEKKNFPW ERLYDLEANE IGELIRVPKL
GKTIYRYIHQ FPKLELSTHI QPITRSTLRV ELTITPDFQW DEKVHGQSEA FWILVEDVDS
EVILHHEYFL LKAKYSTDDH LVKFFVPVFE PLPPQYFLRI VSDRWIGAET QLPVSFRHLI
LPEKNLPPTE LLDLQPLPIT ALRDPSFEAL YADRFPQFNP IQTQVFNAVY NSEDNVFVGA
PTGSGKTTIA EFAVLRLLSQ NPAGRVVYLV ARDPLADLVF HEWHQRFSQS SLGCKVVKLT
GETGTDLKLI AKGQIIVTTA DKWDVLSRRW KQRKNVQNVQ LFIVDELQLI GGEDGPVLEV
ACSRMRYISS QTEQPIRIIA LSASLADARD IAQWLGCGTN ATFNFHPSVR PIPLELHVQG
LNITHNASRV AAMSKPVYNA ITKFSPHKPV IVFVTSRKLA RLTAIDVLTY CAAELQPNRF
FHAEEEDIKP FLDRMTDKTL KETLSQGVAY MHEGLTAADQ RIVEQLFDSG AVQIAICTRD
LCWALNISAH LVIIMDTQFY NGRNHTYDDY PITDVLQMIG RANRPLEDDD AKAVLMCQSS
KKDFYKKFLN EPLPVESHLD HRLHDHFNAE IVTKTIENKQ DAVDYLTWTF LYRRLTQNPN
YYNLQGVTHR HLSDHLSELV ESTLSDLEQS KCIGVEDEMD ALPLNLGMIA AYYYINYTTI
ELFSLSLNSK TKIRGLLEII SSAAEYEDLI VRHHEDNILR SLAGRLPNKL TGPNGTAPKY
NDPHIKTNLL LQAHLSRLQL GAELQGDTEQ ILGKAIRLVQ ACVDVLSSNG WLSPAVAAME
LAQMVTQAMW SKDSYLKQLP HFTTDIIKRC QEKGIETVFD IMELDDDDRT RLLQMTDQQM
SDVARFCNRY PNIELTFSVL DKDRIHSGSS VDVEVALERE DDVTGPVIAP FFPQKREEGW
WVVIGDPKTN SLLSIKRLTL QQKAKVKLNF VAPSPGHHEY TLYYMSDSYL GCDQEYKFSI
NVGDFQSESE SESD
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