ID   A0A182HQB8_ANOAR        Unreviewed;      1459 AA.
AC   A0A182HQB8;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AARA003461-PA.1};
OS   Anopheles arabiensis (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA003461-PA.1, ECO:0000313|Proteomes:UP000075840};
RN   [1] {ECO:0000313|Proteomes:UP000075840}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AARA003461-PA.1}
RP   IDENTIFICATION.
RC   STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA003461-PA.1};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   EMBL; APCN01003306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EnsemblMetazoa; AARA003461-RA; AARA003461-PA; AARA003461.
DR   VEuPathDB; VectorBase:AARA003461; -.
DR   VEuPathDB; VectorBase:AARA21_004408; -.
DR   OrthoDB; 927694at2759; -.
DR   Proteomes; UP000075840; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 7.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR   PANTHER; PTHR24373:SF275; VASORIN; 1.
DR   Pfam; PF13855; LRR_8; 5.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   PRINTS; PR00019; LEURICHRPT.
DR   SMART; SM00364; LRR_BAC; 7.
DR   SMART; SM00365; LRR_SD22; 6.
DR   SMART; SM00369; LRR_TYP; 24.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 4.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 5.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ   SEQUENCE   1459 AA;  164085 MW;  E4F0CE35C47136F4 CRC64;
     MSRCELLLPA LLLLVSVQVN YSLQYDSAES SRYYHPAGAG SEPGSNLRYD APDDCKYRIL
     PGNEVDLACN LRTVNSEFDN TNFSVIPAEH TAALSILCNE AIMARSKLLP NSFVHLARLK
     ALSLEFCKIA KFSSTVLAGL GDLRNFTLRT HNIAWPELNL EIEADAFGQT RNLEVLDLST
     NNIWSLPDHL FCSLSGLRSL NISSNRLQDV NDLGFREKGV KDEVESEGHK TNSSGSVAPP
     VSCALDLEDL DVSRNHFVLL PAAGFGMLKR LKMLKIHDNE ISMVGDKALS GLKELQILDL
     SSNKLVALPT DLFRDPAQSI QEIYLQNNSI SVLSPGLFSK LEQLQALDLS QNQLTSAWVN
     RDTFAGLIRL VLLNLASNKI TKLESEIFSD LYTLQILNLR HNQLEIIAAD TFSPMNNLHT
     LLLSHNKLKY LDAYSLNGLY ALSLLSLDNN ALTGVHPEAF RNCSSLQDLN LNGNELTQVP
     LALKDMRLLR TVDLGENSIS VIEEPGFRGM NNLYGLRLIS NNIENITRKA FKDLPSLQIL
     NVARNKISYI EKGAFEPAVS VQAIRLDGNL LSDIDGLFTS MPNLVWLNIS DNKLEHFDYS
     HIPPHLQWLD LHRNELTELT NRYGLDNQLH LQTLDASFNR LTRVTPATIP NSIEFLFLND
     NLIVHVEPHC FTHKTNLTRV DLYANQLTSL DIKALRLQPV PEDKQIPEFY IGGNPFVCDC
     NIDWLQKINH VTSRQYPTIN DIETVYCKLM YNRERSYIPL IEAEPKHFLC SYNTHCFALC
     HCCEFDACDC EMTCPNNCAC YHDNSWSTNI VECSAAGYTD IPNNIPMDTT EVYIDGNNLV
     ELSGHSFIGR KNLRVLYANH SNIEAIYNTT FIGLRRLTIL HLENNAIRKL YGHEFSALES
     LRELYLQGNR IAYIEDHTFA ELRKLEVLRL DGNRITSFEV WQLSANPYLV EIALANNLWT
     CDCGFVNKLR SYLQSNADKI VDANEISCSY NNATSILRDN GTKCTFREGM SSIVHRQEIE
     DMLPLLLVAT CAFVGFFGLI FGIFCYRKEL KVWVHSGLCY KSGTFVNEYD KDRLYDAYIT
     YSLQDEHFVS QILTSTLEND IGFRLCLHYR DLNANAYLAD TIVEAVESSK RAILVLSKSF
     LYNEWTRFEF KGAIHEVLKR RRKLIIILYG DLPQRDLDAD MRLYLRTNTC IEWDDKKFWQ
     KLRIALPHVK KSNCLNKRSA INIYATAGND YNTPGRPSTL GPSVASTRLD GPQHHSYATI
     GPNCPRNCDN YDTVSNCKYN TTQHHQTHHE RRTTADFGRK ATDGRQHEYA VPSNCLLDTT
     HETYNTTATS CERIAGETFE CTSTSSKFST SSRGSGSDSG SHSISSAAQH DFQGSHRSPN
     GCAPNLLSST TSTTNFSYQH PHPHHHHNGS GRSKPPGPEG VGGGGGKSPS DKHNPGTLGT
     DSRGGNSFND RRLPQAMWA
//