ID A0A182HTF1_ANOAR Unreviewed; 545 AA.
AC A0A182HTF1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Na_H_Exchanger domain-containing protein {ECO:0000313|EnsemblMetazoa:AARA004556-PA.2};
OS Anopheles arabiensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA004556-PA.2, ECO:0000313|Proteomes:UP000075840};
RN [1] {ECO:0000313|Proteomes:UP000075840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AARA004556-PA.2}
RP IDENTIFICATION.
RC STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA004556-PA.2};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|ARBA:ARBA00007367}.
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DR EMBL; APCN01000506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182HTF1; -.
DR EnsemblMetazoa; AARA004556-RA; AARA004556-PA; AARA004556.
DR VEuPathDB; VectorBase:AARA004556; -.
DR VEuPathDB; VectorBase:AARA21_012360; -.
DR Proteomes; UP000075840; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR31102; -; 1.
DR PANTHER; PTHR31102:SF21; NA[+]/H[+] HYDROGEN ANTIPORTER 2, ISOFORM B; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 142..517
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 545 AA; 58196 MW; 1D93A4F6A3DDF096 CRC64;
MPHPLTPPRS AVSRAPTTVP APIPSIDLAM ALSKREATTD GALPLTGMVV VTAETADTGD
WHPVRTTSPS VGNGGTISSS PTPGRTAAFA RKCPSLVRSW PTTSQPLALL LLFAFLWAIA
YAILPPELSE PAGGLMRLAF LFVGAQACGV LVSLTGLPDM LGMLFWGVLY ANVGWADFAG
YERVEVFLRE MALVNIMLLA GLGLDYDALR SLFRFIMQLT LVPTVAEVAA VAVLSHYLLA
LPWLWGVLLG LVVTAISPNV VVTVLLRLRE ERLGLNKGIH TLIIAMTSCN DVLAIFLFGV
ILGVIFSTGD LTSQILQGPI GIVIGLVYGS LCGLALLYLP SYQAKYTNGL RFAMTALAGT
LSVVGSKKVG YPSAGALGCI VTAFVAGTGW RKRPPTECNE VSMYLDLLWK FLKPVSFSLI
GKEVKFSVLE GETVLYGFVT LLVAVLLRLI ASYLSTVGSE LNWKEKAYVT LAGFPKATVQ
AALGPAALDL ARSVNATDEY GRAQTVLIVT VLAIILTAPL GALLMIKLAP RWLKRSTDER
TDQYS
//