ID A0A182HTV9_ANOAR Unreviewed; 1089 AA.
AC A0A182HTV9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
DE Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
DE Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
DE AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
OS Anopheles arabiensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA004719-PA.1, ECO:0000313|Proteomes:UP000075840};
RN [1] {ECO:0000313|Proteomes:UP000075840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AARA004719-PA.1}
RP IDENTIFICATION.
RC STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA004719-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
CC Nucleus {ECO:0000256|RuleBase:RU361195}.
CC -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
CC {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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DR EMBL; APCN01000586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182HTV9; -.
DR EnsemblMetazoa; AARA004719-RA; AARA004719-PA; AARA004719.
DR VEuPathDB; VectorBase:AARA004719; -.
DR VEuPathDB; VectorBase:AARA21_003099; -.
DR VEuPathDB; VectorBase:AARA21_005743; -.
DR Proteomes; UP000075840; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009791; P:post-embryonic development; IEA:UniProt.
DR GO; GO:0050793; P:regulation of developmental process; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051239; P:regulation of multicellular organismal process; IEA:UniProt.
DR CDD; cd10492; MH1_SMAD_4; 1.
DR CDD; cd10498; MH2_SMAD_4; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 3.90.520.10; SMAD MH1 domain; 1.
DR InterPro; IPR013790; Dwarfin.
DR InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR InterPro; IPR013019; MAD_homology_MH1.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR001132; SMAD_dom_Dwarfin-type.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036578; SMAD_MH1_sf.
DR InterPro; IPR007881; UNC-50.
DR PANTHER; PTHR13703:SF45; MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG; 1.
DR PANTHER; PTHR13703; SMAD; 1.
DR Pfam; PF03165; MH1; 1.
DR Pfam; PF03166; MH2; 1.
DR Pfam; PF05216; UNC-50; 1.
DR SMART; SM00523; DWA; 1.
DR SMART; SM00524; DWB; 1.
DR SUPFAM; SSF56366; SMAD MH1 domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS51075; MH1; 1.
DR PROSITE; PS51076; MH2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU361195};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361195};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
SQ SEQUENCE 1089 AA; 117945 MW; BE3C75AE676123A6 CRC64;
MKYATSPTPS RSNSSLLGMS SRTASPLPAP ANYRDCMSAT TKSYKYLRRF IKFDQMDFEY
AMWQMVYLFI APKKVYRNFN YRKQTKSQFA RDDPAFLVLL VGCLCVTSIG FAWVLSLGFL
QTILFTLYVV FVDCIFCGMI VATLLWVIAN RYFRDRNSDF DMEWGYAFDV HLNAFFPPLI
LLHFIQLFFY HPLISRDWFI STFIGNTIWL LALGYYIYIT FLGYNVVPSL KNTRIILVTL
PLLCLFYVVT LIIGWNLSVS LMYYYHYRVL GLLCELRISA NALTAPSRFS KVDTKSNLGL
SQDFERMVGL TGGSHLYAAG IPAAAQEIVR DMAAMPTAAP TSADACLSIV HSLMCHRQGG
ESEGFSKRAI ESLVKKLKEK RDELDSLITA ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF
PHVIYARIWR WPDLHKNELK HVKFCQFAFD LKCDSVCVNP YHYERVVSPG IDLSGLTLQS
GPSRLIKDEY TPGSVVGGGM DIDGNEIGTI QHHPSMVASG AYGTMSMHPQ VPDPSQLGGL
YGASSGPRPI PKLESADPSR NSGPSSWMSG AGSVGGPSSA AAAMLSASSG GQQQHARLSS
SLPLSSVIGG PPGMVNNGLR APPSSQQQPQ QQPSQQPQPS SQSNAQLTNG GSNGLLGSSS
QAGGSGGSSG GGLLGTDGSQ YYTSAADPSM GNDPQTGMGG PASMSGSLSA TSPVSPHLQQ
NGYVSASNGQ SAQAGGPAGG QAQPSQSAAQ QYQPQQQQQQ QQQQQPQSQQ QQQQQQQQQQ
SGSATWSGSN TLNYTQSIQP PAHASGSHQQ QASQQQSQYW PHGSGGSSSA VVAPSGASVG
NATGGQLAGE LPGQQRLLSR QPAPEYWCSV AYFELDTQVG EMFKVPSNRP NVTIDGYVDP
SGGNRFCLGA LSNVHRTEQS EKARLHIGKG VQLDLRGEGD VWLRCLSDHS VFVQSYYLDR
EAGRTPGDAV HKIYPGACIK VFDLRQCHLQ MQSLANCAQK AAQMQAAVVA GVSAVGAPRS
LSAAAGIGVD DLRRLCILRL SFVKGWGPDY PRQSIKETPC WVEVHLHRAL QLLDEVLHQM
PIDGPRAIE
//
