ID A0A182HV19_ANOAR Unreviewed; 566 AA.
AC A0A182HV19;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=TGF_BETA_2 domain-containing protein {ECO:0000313|EnsemblMetazoa:AARA005136-PA.2};
OS Anopheles arabiensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA005136-PA.2, ECO:0000313|Proteomes:UP000075840};
RN [1] {ECO:0000313|Proteomes:UP000075840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AARA005136-PA.2}
RP IDENTIFICATION.
RC STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA005136-PA.2};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; APCN01002490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182HV19; -.
DR EnsemblMetazoa; AARA005136-RA; AARA005136-PA; AARA005136.
DR VEuPathDB; VectorBase:AARA005136; -.
DR VEuPathDB; VectorBase:AARA21_010825; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000075840; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13760; TGF_beta_BMP2_like; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF263; PROTEIN DECAPENTAPLEGIC; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 448..566
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 566 AA; 63191 MW; 3AF6D1F230D965F5 CRC64;
MTRERLRAHA APCPPGCSET RGLARQRRAA SGTRTRSTMI GRQTSRRLLP ATMHVWFYVL
AVLAISHGAT RVASTDSSSP ARTKAASLLH SDQSHISHPF NQPALRQGSA DSTPPVTDVS
PEPRIGGTGA PEAASIKSSE TIEYEEYVAA KDAAVEVDTE GPAEEPELEN EISDSEPDTV
DTVVVESRPD PKTLVEIEKN LLSLFGFPNR PKIDRSKVVI PEAMKQLYAQ IMGHDLVDSV
SVPKEGLNTR NANTVRSFTH EESHIDQRFQ HHHRFRLLFN VTSIPRGEKL RAAELTLTRE
GIAHRSSRAQ ARTPVLYQVM VYDIVRPGVK GKRAPTFLLV DTKTLAINES GTASFDVMPA
VERWLRQPRK NHGLFVQVTG RGRGPPGHSR QRRSIVPAVP VHEHVRLRRN AAERHDSWVQ
KQPLLFTYTD DGRHKQRPIR DAISSANRAR RASAKRSSRR KNELCQRKPL YVDFSDVGWN
DWIVAPPGYE AYYCQGDCRF PIADHLNTTN HAIVQTLVNS YNPTLAPKAC CVPTQLSSIS
MLYLNEQNKV VLKNYQDMTV VGCGCR
//