ID   A0A182I050_ANOAR        Unreviewed;      4725 AA.
AC   A0A182I050;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS   Anopheles arabiensis (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA006929-PA.1, ECO:0000313|Proteomes:UP000075840};
RN   [1] {ECO:0000313|Proteomes:UP000075840}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AARA006929-PA.1}
RP   IDENTIFICATION.
RC   STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA006929-PA.1};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC       intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   EMBL; APCN01002043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EnsemblMetazoa; AARA006929-RA; AARA006929-PA; AARA006929.
DR   VEuPathDB; VectorBase:AARA006929; -.
DR   VEuPathDB; VectorBase:AARA21_004392; -.
DR   Proteomes; UP000075840; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   CDD; cd00009; AAA; 2.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.472.130; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 2.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 1.20.920.60; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR013594; Dynein_heavy_tail.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR   PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08385; DHC_N1; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 2.
DR   SMART; SM00382; AAA; 4.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          1912..2063
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2226..2377
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2597..2747
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2939..3105
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
SQ   SEQUENCE   4725 AA;  539247 MW;  676B9859989791E0 CRC64;
     MGDSLEATMP SMGSEQPPSV EPEAVAIIDF DNFSNYLRKA ITVLLPEDDM KSFGPLNAAL
     EDSVNQDCIR KFISDPQTQA LYIQRNCFKD DENEPPTEGE EEKDSITYYF GNDVHFTNQR
     MASLVCIKRG AMIEADKSIH SQVRLINFSE GSPYETLHAF ISKTLAPFFK SYVKESGRAD
     RDGDKMAPSV EKKLAELEMG LLHLQQNIDI PEVTLNINST VAQVVKKCAD EQRKAKITDF
     GDKVQDSTFL NTLQNGVNRW IKEIQKVTKL DRDPSSGTAL QEISFWLNLE RALHRIQEKR
     ESPEVALTLN ILKHGKRFHA TVSFDTDTGL KQTLAMVADY NPLMKDFPIN DLLSATELDK
     IRQAVHSIFN HLRKIRNTKY PIQRCLRLIE AISRDLSQQL LKVLGTRRLM HIPFDEFERV
     MNQCFEVFSC WDDEYDKLLG TLREIVKRKR DEHIKMVWRI SPAHKILQQR MEHMRKFRRQ
     HEQLRTVIVR VLRPTRQPSS ALSAAGDTGV GGEGKQPYSL DTADANAIEE VNLAYENVKE
     IECLDISKEG SEAWDAAIKR YEERIDRVEA RITAHLRDQL GTAKNANEMF RIFSRFNALF
     VRPHIRGAIR EYQTQLIQRV KDDIEALHEK FKVQYPQSKS CRLSVVRDLP PVAGSIIWAR
     QIDNQLTMYL KRVEDVLGRG WESHIDGQKL KADGDSFRAK LSTAEVFQDW ARKVQERNTG
     ITGRIFSIEA TRSRTGRGNT LRLRVNFLPE IITLYKEVRN LKSLGFRVPL AIVNKAHQAN
     QLYPFAISLI ESIRTYERTL EKIEDRASII PLVAGLRKEV LSLISEGIAL VWESYKLDPY
     VQRLSENVVS FQEKVEDLLV VEEQLDVDVR SLETCPYSAA TFADILSKIQ HAVDDLSLKQ
     YSNLHVWVAR LDEEVEKKLA ARLQAGIQAW TDALTGNKKE VDLSMDTDAP TQPTIRPGGD
     PQIQRAIHEI RITNQQMYLY PSIEEARFQI MQQLFAWEAI VTSQTRLQSS RYQVGLDKPV
     SQTYRNLLTK LPNKPDPLEG AYAAIENQIG DVRSYVDEWL RYQSLWDLQA DMLYGRLGED
     INLWIKCLND IKKSRTTFDT SDTRRAYGPI VIDYAKVQAK VTLKYDSWHK EALSKFGQLL
     GNEMSTFHSK VSKSRSDLEQ QSIEAASTSD AVCFITYVQS LKKEMLVWDK QVEVYREAQR
     ILERQRFQFP NNWLHVDNIE GEWSAFNEIM KRKDSAIQTQ VASLQAKIVA EDKAVETRTV
     DFLNDWEKNK PTGGRTRPDD ALQQLHIFET KFSRLKEERD NVAKAKEALE LQESAIPNNS
     TERMSVVLEE LQDLRGVWSE LSKVWAQIDE TREKPWLSVQ PRKLRQSLEA MMNQLKELPA
     RLRMYESYEY VKKLLQSYIK VNMMIVELKS DALKERHWKQ LTKQLRVSWV LSDLTLGQVW
     DVNLLKNESI VKDIILVAQG EMALEEFLKQ VRESWQNYEL DLINYQNKCR IIRGWDDLFN
     KVKEHINSVA AMKLSPYYKV FEEEALTWEE KLNRINSLFD VWIDVQRRWV YLEGIFSGSA
     DIKTLLPVET SRFQSISSEF LGLMKKVAKS PKVMDVLNIP AVQRSLERLA DLLGKIQKAL
     GEYLERERTS FPRFYFVGDE DLLEIIGNSK NVARLQKHFK KMFAGVASIL LNEDNTVILG
     IASREGEEVR FIKPVSTIEH PKINEWLSLV EKEMRFTLAS YLAQAVQDIK QFKDVIDTQK
     YMEWCDKYQA QIVVLAAQIL WSEDVENALQ QTSEGNGGTG GNGKDKTPLH RVLTTVETTL
     NVLADSVLQE QPPLRRKKLE HLINEFVHKR TVTRRLIAHG VNNPKSFHWL CEMRFYFDPR
     QTEVLQQLTI HMANARFYYG FEYLGVQDRL VQTPLTDRCY LTMTQALEAR LGGSPFGPAG
     TGKTESVKAL GNQLGRFVLV FNCDETFDFQ AMGRIFVGLC QVGAWGCFDE FNRLEERMLS
     AVSQQIQTIQ EALKSQQDAN RDAQSITVEL VGKQVRVSTD MAIFITMNPG YAGRSNLPDN
     LKKLFRSLAM TTPDRQLIAE VMLFSQGFRT AEKLACKIVP FFKLCDEQLS NQSHYDFGLR
     ALKSVLVSAG NVKRDRIMKI KDTKKQQGEE NIDEASIAEN LPEQEILIQS VCETMVPKLV
     AEDIPLLFSL LSDVFPNVGY TRAEMKGLKD EIRKVCSEEY LVCGEGDEQG GAWMEKVLQL
     YQISNLNHGL MMVGPSGSGK SSAWKVLLKA LERFEGTEGV AHVIDPKAIS KEALYGVLDP
     NTREWTDGLF THILRKIIDN VRGEINKRQW IIFDGDVDPE WVENLNSVLD DNKLLTLPNG
     ERLSLPPNVR IMFEVQDLKY ATLATVSRCG MVWFSEDVLS TEMIFENYMS RLRHIPLEDG
     EEESFSGQPK GSTEKEDEVT PALQTQREIA ALLQPYFSSD GLVVRCLEYA MGQEHIMDFT
     RLRALSSLFS MLNQGARNVL TFNQQHPDFP VPPEQLEQYI PKLLIYSMLW SFAGDSKLKV
     RSDLGDFLRS ITTVTLPAQG ANPIIDYEVN IQGDWVPWSN KVPVIEIETH KVAAPDVVVP
     TLDTVRHESL LYTWLAEHKP LVLCGPPGSG KTMTLFSALR ALPDMEVVGL NFSSATTPEL
     LLKTFDHYCE YRKTPNGVVL APVQLGKWLV LFCDEINLPD MDSYGTQRVI SFLRQLVEHK
     GFYRAADQSW VSLERIQFVG ACNPPTDPGR KPLSHRFLRH VPIIYVDYPG ETSLKQIYGT
     FSRAMLRLMP NLRGYAEPLT NAMVEFYLAS QDRFTQDMQP HYVYSPREMT RWVRGICEAI
     RPLDNLPVEG LVRLWAHEAL RLFQDRLVEE SERRWTNENI DLVATKHFPS VDRDKALARP
     ILYSNWLSKD YMPVNRDELR DYVKARLKVF YEEELDVPLV LFDEVLEHVL RIDRIFRQPQ
     GHLLLIGVSG AGKTTLSRFV AWMNGLSIFQ IKVHNKYTSE DFDEDLRCVL RRSGCKDEKI
     AFILDESNVL DSGFLERMNT LLANGEVPGL FEGDEYTTLM TQCKEGAQRE GLMLDSSDEL
     YKWFTQQVMR NLHVVFTMNP STDGLKDRAA TSPALFNRCV LNWFGDWSDS ALFQVGKEFT
     IRVDLEKPTW SAPDFFPAVC PLVSNTPSHR DAVINSCVYV HQTLHKANAR LAKRGSRTMA
     ITPRHYLDFI HHFVKLYSEK RSDLEEQQLH LNVGLNKIAE TVEQVEEMQK SLAVKSQELQ
     AKNEAANAKL KQMFKDQQEA EIKKVQSQEI QQQLAEQTVK IEEKRKDVMA DLAQVEPAVI
     DAQAAVGNIK KKQLAEVRTM ANPPLPVKMA LESVCLLLGE DDRGGDWKAI RAIMVKDSFI
     ASISIKKQHL VEVRSMANPP AVVKLALESI CLLLGENASD WKSIRAVIMR ENFINLIVSN
     FSTEDITDEV REKMKSKYLS NPDYNFEKVN RASMACGPMV KWAIAQVEYA DMLKRVEPLR
     EELSSLERQA DTNIKHGREV KELIAQLEQS IAAYKEEYAQ LISQAQAIKT DLENVQAKVD
     RSIALLKSLV IERERWEATS ETFRSQMSTI VGDVLLSAAF IAYGGYFDQH YRSNLFSTWC
     QHLQAANIQF RADIARTEYL SNPDERLRWQ ANALPTDDLC TENAIMLKRF NRYPLIIDPS
     GQATEFIMNE FKDKKITKTS FLDDSFRKNL ESALRFGNPL LVQDVENYDP ILNPVLNREL
     RRTGGRVLIT LGDQDIDLSP SFVIFLSTRD PTVEFPPDIC SRVTFVNFTV TRSSLQSQCL
     NQVLKAERPD IDEKRSDLLK LQGEFHLRLR QLEKSLLQAL NDAKGKILDD DSVITTLETL
     KKEAADIGQK VEETDKVIGE IETVSQQYLS LSQACSNIYF TMDSLNQVHF LYQYSLKMFL
     DIFSTVLHNN PKLEGKSDHT ARLLIITSDL YRVCYDRVAR GMLHADRLTF AILLCRIHLK
     GTAEPNLDQE FNFFLRNKEG LVASASHVDG VSAEQLESVT RLATRLPIFR KLLDKIKSMP
     ELTAWLQQGS PEQNVPVLWD ESKALSAISA AMHQLLLIQA FRPDRVIAAA HLFVSTVLGE
     DFMPQAEKEL DFAACVEKEL TSNTPALLCS VTGYDASSRV DDLAAELNKQ ISSIAIGSAE
     GFNQAERAIN MACKSGRWVL LKNVHLAPQW LVQLEKKLHS LQPHSGFRLY LTMEINPKVP
     VNLLRAGRIF VYEPPPGIRA NLLRTFSTVP AARMMKQPSE RARLYFLLSW FHAIVQERLR
     YVPLGWAKKY EFNESDLRVA CDTLDTWIDA TAMGRTNLPP EKVPWDALVT LLSQSIYGGK
     IDNDFDQRLL ASFLSKLFTA HSFEAEFALV ANVDGVAGGP NGQRHITMPD GTRRDHFLKW
     IEALADRQTP SWLGLPNNAE KVLLTTRGTD LISKLLKMQQ LEDDDELAYS NDESLDTMQT
     RQEDGRPSWM KTLHNSALTW LELLPKSLAT LKRTVENIKD PLYRYFEREV SSGAKLLQTV
     VSDLQDVVFI CQGEKKQTNY HRTMLSELVR GILPAGWRRY TVPAGCTVIQ WITDFSQRVQ
     QLQKVSTLVS QAGAKELQSF PVWLGGLFNP EAYITATRQC VAQANSWSLE ELTLTVTITE
     SGSDSYDNLK DSSFGVSGLK LQGAQCKNNQ LLLTSAIMTE LPLTLLKWTR IDSESARATK
     LTLPVYLNST RVELLFTVDM TVAPGQDPHS FYERGVAVLA STALN
//