ID A0A182I1M1_ANOAR Unreviewed; 427 AA.
AC A0A182I1M1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=FAM69 N-terminal domain-containing protein {ECO:0000259|SMART:SM01299};
OS Anopheles arabiensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA007467-PA.2, ECO:0000313|Proteomes:UP000075840};
RN [1] {ECO:0000313|Proteomes:UP000075840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AARA007467-PA.2}
RP IDENTIFICATION.
RC STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA007467-PA.2};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the DIPK family.
CC {ECO:0000256|ARBA:ARBA00006338}.
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DR EMBL; APCN01000069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182I1M1; -.
DR EnsemblMetazoa; AARA007467-RA; AARA007467-PA; AARA007467.
DR VEuPathDB; VectorBase:AARA007467; -.
DR VEuPathDB; VectorBase:AARA21_005996; -.
DR OrthoDB; 2968643at2759; -.
DR Proteomes; UP000075840; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR022049; FAM69_kinase_dom.
DR InterPro; IPR029244; FAM69_N.
DR PANTHER; PTHR21093:SF2; DIVERGENT PROTEIN KINASE DOMAIN 1C; 1.
DR PANTHER; PTHR21093; UNCHARACTERIZED; 1.
DR Pfam; PF12260; PIP49_C; 1.
DR Pfam; PF14875; PIP49_N; 1.
DR SMART; SM01299; PIP49_N; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 22..182
FT /note="FAM69 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01299"
SQ SEQUENCE 427 AA; 49117 MW; EE81D88842D98A7F CRC64;
MTISSNSALV LHNRFKNMTR RLRFSPRRRQ YCVLTSAAIL LLVVVGVVGY LLTGMHYCFD
VLVEWKVSEI CNQYYTNEVT GYMCPELCAG DTISEFHCPP TAHAAAYPFN AHRFLARKAQ
QFVVVKHAVP DASYEKLSWI DSHRQEEHYP TEQEYGGIVR RYIELRYGVQ LPFDKLAGLL
ALKNKNNRIL FHASMRNSWN LIQNNEYLLS RLYEEKEIFP QVLGTCGELF LTELLETVEF
VDEGRYHFTN HIDLSKWRYH LKVAVLVLDY LDEMGQNRFQ MCSVVLGGFG ISDSRMKYHD
LRYISTEATI DRRLSDGRTC AVDADCSYYD CRSRCNATSH QCTAGLLNNN LQIVCEKIFR
GTAEEPGILV TEKSSPRLLR ILDRCARPAS RSDVDAARPW GPSKTLKKQL YNELTSIYEQ
LASSLYS
//
