ID A0A182I3L0_ANOAR Unreviewed; 1874 AA.
AC A0A182I3L0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Kinesin motor domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles arabiensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA008156-PA.1, ECO:0000313|Proteomes:UP000075840};
RN [1] {ECO:0000313|Proteomes:UP000075840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AARA008156-PA.1}
RP IDENTIFICATION.
RC STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA008156-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; APCN01000214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EnsemblMetazoa; AARA008156-RA; AARA008156-PA; AARA008156.
DR VEuPathDB; VectorBase:AARA008156; -.
DR VEuPathDB; VectorBase:AARA21_015389; -.
DR Proteomes; UP000075840; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22706; FHA_KIF13; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF3; KINESIN FAMILY MEMBER 14-LIKE; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM01052; CAP_GLY; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}.
FT BINDING 71..78
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1874 AA; 208725 MW; 1DC20B825873E166 CRC64;
MCLLLTLLLI HCFCSVSCRK PPKIFAFDHC FYSTDANANN FASQELVFNN IGRDILENAF
QGYNACIFAY GQTGSGKSYT MMGSQDSKGI IPRLCDELFA SIAAKQTDEL NYKVEVSYME
IYNEKVHDLL DPKTAKQSLK VREHNVLGPY VDGLSQLAVT SFLDIDNLMA EGNKSRTVAA
TNMNSESSRS HAVFTVVLTQ TLIDTLSGVT GEKVSRVSLV DLAGSERAVK TGAVGDRLKE
GSNINKSLTT LGLVISKLAD STGGKNKDKF VPYRDSVLTW LLKDNLGGNS RTVMLATLSP
AADNYEETLS TLRYADRAKR IVNHAVVNED PNARIIRELR KEVETLREML KHATGSNFGD
MKRVDIHDKL AESENLMKQI SQTWEEKLEK TEQIQSERQQ ALEKMGISVQ DSGIKVEKNK
YYLVNLNADP SLNELLVYYL KEETLIGGRS SSGSKQPDIQ LLGLGIQPEH CLITIEDGEL
YMDPIENARC YVNGSVVSDK MALHHGDRIL WGNHHFFRVN CPKSATNSTA LGSSEPQTPA
QHMDYYYAQE ELMQNELSNN PIQAAISRLE KQHEEDKQVA LEKQRQEYEK QFQQLRNILS
PTTPYAPYAP YDPFRLGKLP PNTPTAQLRV EKWAQERDEM FKRSLGQLKT DIVRANALVQ
EANVLAEEMD KQTKFSVTLQ IPPANLSPNR KRGAFVSEPA ILVRRMNSGS QIWSMEKLEN
KLIDMRDMYQ DYKERHQAAM EEAKAKSDPF YESQENHNLI GVANIFLEVL FHDVKLDYHT
PIISQQGEVA GRLQVEISRV AGTFPQDRMC ESASESSADS HEDDEDSPDT PSPPPPTNSN
QISCRISIKQ ASGLPLYLSN FVFCQYSFWN HEVAVVPATN QEVAGHNQNI TFKFDHEADY
IVTMNEEFLE HCSDGALSIE VWGHRSVGFS RMKDWEVEQQ QAKARSLADR WAELSRKIEL
WVEIHELNDN GDWAPVEVQC ARDMLTGGVY QLRQGFQRRV MVRVKPVQNS GTLPIICQSI
INVSMGCVTV RSKLQKPMDS YQEEDLTVLR DKWSEALGRR RQYLDQQIQR LINKDDKTEQ
EKEREQSLVN QWVSLTEERN AVLVPAPGSG IPGAPASWDP PLGMEPHVPV LFLDLNADDL
STQGLSNDEV PMAGLNSILP KEHGNKFYNL QIIQHLDKDI CAICSWDSSI HDCAALNRIT
EANERVYLIL KTTVRLSHPA PMDLVLRKRL ALNIYKRQSF TDRLKKLRIG RAESLSLQSG
VTYEVVSNIP KASEELEDRE SLAQIAATGD DCSASDGETY IEKYTKGVSA VESILTLDRL
RQSVAVKELE QVRGPALSMR KTASVPNFSQ MRFFDASFES LLSIGRSESY ADLKMGLNNA
QSTRETANSR QKMKNNNGEE SSSSGYGAAS PAASKLAQRM TTLHEEPLIK QICYEEEGED
HFSEPDYPEY NDFYEQPMGK KPSLSKMKSS YTVESFIDID KRSQSAGGEG MNSAGGKFAS
KTKAESASMG GISSAPVSGG SAGGPGAKYQ TMTPSMSSST SSGYGSQAVS CSNLTNDDTY
SIRSMSVGET PDTMSPSNKM QEQIMSTSSS TNAKSEEESV TSPTTSTTAS EHTLMAESMD
SYSSSPTTRA PLGEMPKRVN PFLKDANIEA FDDSSAQLDA AKDEQPQQQA SEEDEGLGGE
QSQSESTTTM SDSTQMVDES EESDHSSANT KHSSDVMESS FSSTPGKQEI IPDWVVVGES
VLIRPYNTSG VIAFVGATHF QGGTWIGVEL DTPTGKNDGT VQGIQYFDCR PKHGIFVRVD
KLILDKRGRA MRELKKAEKM KGRTKATDRR HRNGNEWTTQ MIRVQSWPQQ RSVFVEAVHG
PEAVCAEICL RCSI
//
