ID   A0A182I546_ANOAR        Unreviewed;      1107 AA.
AC   A0A182I546;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Receptor ligand binding region domain-containing protein {ECO:0000259|Pfam:PF01094};
OS   Anopheles arabiensis (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA008696-PA.1, ECO:0000313|Proteomes:UP000075840};
RN   [1] {ECO:0000313|Proteomes:UP000075840}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AARA008696-PA.1}
RP   IDENTIFICATION.
RC   STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA008696-PA.1};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
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DR   EMBL; APCN01003776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A182I546; -.
DR   EnsemblMetazoa; AARA008696-RA; AARA008696-PA; AARA008696.
DR   VEuPathDB; VectorBase:AARA008696; -.
DR   VEuPathDB; VectorBase:AARA21_012343; -.
DR   Proteomes; UP000075840; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR   CDD; cd06366; PBP1_GABAb_receptor; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR002455; GPCR3_GABA-B.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR   PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          329..701
FT                   /note="Receptor ligand binding region"
FT                   /evidence="ECO:0000259|Pfam:PF01094"
SQ   SEQUENCE   1107 AA;  124587 MW;  21D3476029C13ADA CRC64;
     MASVKRYGGE WPDPTIDLEV WLLSDYHYIP GEIREAGAIA NPGRFGLFLP KALIRKEDNF
     PKPLIYTLFQ EDSNNHRYYD FIKKFDISQP VLESIYRYAE RKCDNDCDDY GMFVPTQCTQ
     GVKCALVLAP HYEDTRFLVQ HITEMNFQLK VIWLGDRLKL GIRQLMNTYG GDRKNGKKFL
     VFHWTPSEVI NTRTMEYVPI TMPRCEDMIA SNDTGCKYEM TPLLKYYGKK FREADYAFNS
     LILTHFEEQS MQQIFDLYDA HEPEIMRVRE EGDPDQTRVA EIYNQIACEW MRAQESTWMR
     WKPEDPKEEV YIGGIFPLTG MGPSYLGIAP AALLAQDHIN GNGTILPNYE LTVQQNDGQC
     RADTVMKSFI SYYIQQTRMI GILGPACSET VEPIAGVSKH FRMAVISYSA EGAFLSDREK
     YPFFFRTIGE NRQYEHVYAQ LLQRMNWRRV AALTEDGQKA TEYISYMETL LKERSIELIS
     NKKFPRDRTD TEMNQYLLDL KSKSAKIIIA DVDDKVARVI MCEAYKLEMT AENGYIWFLP
     IWLSNVWNFS SEVPGGENGA TAVPPTSTNR TTRSCTNSEL LRAMNGHFSL SHAPYADDDS
     ILDVNRSATV RDWKQAYNVS LSEYNYMASD YAGFAYDAVW VYALAFDRLL REDPSYISDL
     HSRHTTKRLM ELIRETDFQG VTGRIKFNEA GSRYTIVNVL QFVNGTANIV GHFTPNISEP
     DYKLLGGDLV LNESAIVWMT RDGHIPDDGT PVCALESFVR IFGISCDEVT MIVISMVSII
     SILILSVASF LFWKVRYDRK MQTSAKYLQK LGIDLLSQTS GPDYKKRPSA SEVSEFISNY
     PRLLNPCLDV PLASVEMVDT GSDQFELLPG LRKYKDESQQ PTADLLVGTQ PMNDLNNGYN
     NVSIMSTGGA QRAHNRARAI NLNDLNVATD FTTVNPMPPL DDYVEEEPAM ARRQPFGGSS
     STQRQTTSTN HLNVYNPIEP LLQRDTEVTK SNNSLLRYVP MFGFGKSKTV TIGGTTIVTG
     GAAGAGGTGA GRTVPPTTAL HCTTSLGAMA GPSSPQSPTG SVLGMSGGTM IHAKDEAKEK
     LCSGKVTDEP EQTHVMVDRG GVASEDN
//