ID   A0A182I5B6_ANOAR        Unreviewed;       722 AA.
AC   A0A182I5B6;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 2.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AARA008768-PA.2};
OS   Anopheles arabiensis (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA008768-PA.2, ECO:0000313|Proteomes:UP000075840};
RN   [1] {ECO:0000313|Proteomes:UP000075840}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AARA008768-PA.2}
RP   IDENTIFICATION.
RC   STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA008768-PA.2};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC       phagocytosis of apoptotic cells and cell motility. Acts in association
CC       with DOCK1 and CRK. Was initially proposed to be required in complex
CC       with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC       nucleotide exchange factor (GEF) activity of DOCK1.
CC       {ECO:0000256|ARBA:ARBA00024863}.
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DR   EMBL; APCN01003844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A182I5B6; -.
DR   EnsemblMetazoa; AARA008768-RA; AARA008768-PA; AARA008768.
DR   VEuPathDB; VectorBase:AARA008768; -.
DR   VEuPathDB; VectorBase:AARA21_011372; -.
DR   Proteomes; UP000075840; Unassembled WGS sequence.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR   CDD; cd13359; PH_ELMO1_CED-12; 1.
DR   Gene3D; 6.10.250.810; -; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024574; ELMO_ARM.
DR   InterPro; IPR006816; ELMO_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR12771:SF56; CED-12; 1.
DR   PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR   Pfam; PF11841; ELMO_ARM; 1.
DR   Pfam; PF04727; ELMO_CED12; 1.
DR   Pfam; PF16457; PH_12; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51335; ELMO; 1.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW   SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
SQ   SEQUENCE   722 AA;  82326 MW;  485443843E31DF7A CRC64;
     MLPKHSKMPA IKDSHIVKIA VEYVDNTPQM YPQLIEFDQR QPLGAIIQNL CSSWGIPDAE
     SYALQFDGIN YVTEKNRNEV KNGTVLKLRF SPSKTTNDIL EKLRSGTEDE KVAELKELQV
     LSADNTFALE FIKEQGLRLI IALIEDGQCE ERILELALCS FVQLMEHGTI SWDILEPSFI
     MRNVAFINGS SKPEIIQSAL SILENIVQSS NKYALVEKEI TLETLLKLLR DATRTQVQQN
     AIALLNALFI KADDGKRRML AATLGSKQYR SVINSVITPT MGAEMAHQLY VLQTLTLGLL
     EQRMKTAMDV QDQDAQEKIK ELRRIAFEAD GIEPMPDVTA RRQHGSSYSS HYKKLGFKCD
     INPAQDFFET PPGTLALDCM IYFARNYTQS YTKVVHENSC RADEHECPFG RTSIELVKVL
     CDIFRIGESP SEQGQEFYPM FFTHDHPFEE FFCICIVVLN KTWKDMRATT EDFVKVFSVV
     REQIVRSIVG RPASLEDFKA KIHTFTYNTI TTLRQQERTS REECESTASA IVSLKKKITP
     EIRALIKEQR LGYLIVGTRF CKYSGGKRER DKYWYVRLSP NHKVIHYGDC DEKTVPTLEE
     LSNKLPVIDI RQMLVGKECP HMKEMRSKKA STPLGFSLVP ESSEQPTLDF IAPDEATFNY
     WTDGINALLG QPMTSKQQEE DFETLLSMEI KLRLLDTEGV DISKDPPAIP PEPENYDFCF
     DS
//