ID A0A182I9B7_ANOAR Unreviewed; 1865 AA.
AC A0A182I9B7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Transcription elongation factor spt6 {ECO:0000256|PIRNR:PIRNR036947};
OS Anopheles arabiensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA010177-PA.2, ECO:0000313|Proteomes:UP000075840};
RN [1] {ECO:0000313|Proteomes:UP000075840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AARA010177-PA.2}
RP IDENTIFICATION.
RC STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA010177-PA.2};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- FUNCTION: Transcription elongation factor that enhances transcription
CC elongation by RNA polymerase II (RNAPII).
CC {ECO:0000256|PIRNR:PIRNR036947}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036947}.
CC -!- SIMILARITY: Belongs to the SPT6 family. {ECO:0000256|ARBA:ARBA00009253,
CC ECO:0000256|PIRNR:PIRNR036947}.
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DR EMBL; APCN01003250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EnsemblMetazoa; AARA010177-RA; AARA010177-PA; AARA010177.
DR VEuPathDB; VectorBase:AARA010177; -.
DR VEuPathDB; VectorBase:AARA21_007472; -.
DR Proteomes; UP000075840; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0032968; P:positive regulation of transcription elongation by RNA polymerase II; IEA:UniProtKB-UniRule.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd00164; S1_like; 1.
DR CDD; cd09928; SH2_Cterm_SPT6_like; 1.
DR CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 1.10.10.650; RuvA domain 2-like; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 1.10.10.2740; Spt6, Death-like domain; 1.
DR Gene3D; 1.10.150.850; Spt6, helix-hairpin-helix domain; 1.
DR Gene3D; 1.10.3500.10; Tex N-terminal region-like; 1.
DR Gene3D; 3.30.420.140; YqgF/RNase H-like domain; 1.
DR InterPro; IPR041692; HHH_9.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR028083; Spt6_acidic_N_dom.
DR InterPro; IPR042066; Spt6_death-like.
DR InterPro; IPR032706; Spt6_HHH.
DR InterPro; IPR028088; Spt6_HTH_DNA-bd_dom.
DR InterPro; IPR035420; Spt6_SH2.
DR InterPro; IPR035018; Spt6_SH2_C.
DR InterPro; IPR035019; Spt6_SH2_N.
DR InterPro; IPR028231; Spt6_YqgF.
DR InterPro; IPR023323; Tex-like_dom_sf.
DR InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR InterPro; IPR017072; TF_Spt6.
DR InterPro; IPR006641; YqgF/RNaseH-like_dom.
DR InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR PANTHER; PTHR10145; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR PANTHER; PTHR10145:SF6; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR Pfam; PF14635; HHH_7; 1.
DR Pfam; PF17674; HHH_9; 1.
DR Pfam; PF14641; HTH_44; 1.
DR Pfam; PF00575; S1; 1.
DR Pfam; PF14633; SH2_2; 1.
DR Pfam; PF14632; SPT6_acidic; 1.
DR Pfam; PF14639; YqgF; 1.
DR PIRSF; PIRSF036947; Spt6; 1.
DR SMART; SM00316; S1; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00732; YqgFc; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 2.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF158832; Tex N-terminal region-like; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036947};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036947};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR036947}.
SQ SEQUENCE 1865 AA; 213506 MW; 73B99DF24A976AFD CRC64;
MADFIDSEAE ESEDEEELEP HERKRLKKNK AVSDSEDEEE DDEDRLREEL KDLIDDNPIE
EESDNDDSDD GSEGGHQKRK KSDDELDDRL EDEDYELIEE NLGVKVERKR FKRLKKFTND
DGSDGESGDE GMIRETIENR LFDAASEEDE ERASDHEGGQ RDTMANVREH YDEEEDEESD
ADDFIVDDDG VPISDKRKKR RHIFTDASLQ EGQDIFGVDF DYDEFEKYDD EYEEGSEAED
EYEEEQLDQA DRPSGERGKK SKPAARKRML KKSIYEIYEP SELKRGHFTD LDNEIRKIDI
PERMQLRDIP VTAVPEGSNE LEEEAEWIYQ QAFCKPHVSD QGAMTRKPPS NVPKIKHALD
FMRNQHLEVP FIAFYRKEYV QPDLNINDLW KIYKFDSMWC QLLGRKTSLQ RLYENMRNYQ
LDKLMENPDA PIPEDMRVIR DEDLSRLRSV QSHEELKDVH LHFLLYYAHD IAPMRLRTRE
KSGQQQQQST QRVQKKARAP KKKNPEDGEG AGEDGAEGEE NGDEDKEEDA EEEDEEEEKQ
EEETVGGSGG GKAVDDAGKE RVRLNIDVGP YEICRKRGLT GLTKRFGLTP EQFAENVRDS
YQRHEVEQET KEPLEVAKEY MGTTFESPEE VLQGGVFMVA RQLAREPLFR KCIRELYFER
AKLNVRPTKK GMKEIDETHH CYAMKYLKEK PVRDLTGDQY LKLYIAQEDK LLTMEFVDRI
EGNTSGDFLE ELKALYHRDE FAKNVQEWNK VRAECVVLAV NRMVIPDLKR ELHNTLLTEA
KDAVLRVCCR KLYNWIKVAP YKPPVPDFDD YEWETTRGVR VMGVAYVPDY TQSAFGAIIA
PDGEVTDYLR IPHLLKKKNA YRESEKQCKE SDLRTITNFI RSKKPHVIVI GGESKDALMV
QQDFVECVKR LQEEEQFPQI AVEIADNELA KVYANSVKGT TDFKEYPPLL RQAISLARRI
QDPLVEFSQL CNSDEEILCL RYHTLQEQLT KEELLENIQL EFINRTNEVG VDVNLAVQNP
LTANLVQFIC GLGPRKGQTL LKVLKQTNSR LENRTQLVTT CHMGPKVFIN CSGFIKIDTN
SLGDSTETYV EVLDGSRVHP ETYEWARKMA VDALEYDDEE ANPAGALEEI LEAPERLKDL
DLDAFAIELD RQGFGNKSIT LYDIRAELNS RYKDLRTPFR SVTAEELFDY LTKETPESLF
VGKMMLATVS GFTYRKPQGE QLDQANPVRN DETGFWQCPF CMKTEFPELS EVWNHFDAGE
CPGQATGVRV RFDNGLNGFI HIKNLSDKHV KNPEERVQIG QTVHVRVTKI DIERFSLECS
SKSSDLCDRK QEWRPRKDPC YDQELEEADT RKEADSKKQQ ARQQYVKRVI VHPSFHNISY
AEALKLLEGY DQGDVIVRPS SKGSDHLTAT WKVTDGIYQH IDVREEGKEN VFSLGQSLWI
GNDEFEDLDE IIARHITPMA TYVRDLLNYK YYRDTDGGSK EKAEEIIKAE KQKNPNKIHY
IVSVSKTYPG RFLLSYLPRN KFRHEYVTVT PDGYRFRHQT FDSVNSLLKW FKEHFRDPIP
IDTPKSTPKV GGMSSRTPYG STPKFSDINS ETIESVAKNM PTHMLNSLSA AAHHTPHYSY
TPLEYGSSNF VTTPYTPSGQ TPYMTPYQQT PHFSQTPRYG TSTPSQYSNK SAYTGIPTGH
PPPSASHHGY KSTSAARGMG GVSSAASSSS SSLMMMQQPS PYSNSSDHHY RTQQPPMHHH
ARNNEYDSWS KATDSWSNRG NSSNMMKGHH GASERSSGGS YHHHHHSGGG GVGRSSDSVT
SSSSHDHRMT PRSSSKYSAT RSPMPPPAQP PPQPTQAQPA QQAAAAAASS AASLTLGDAT
PLWDE
//
