ID A0A182I9L5_ANOAR Unreviewed; 1021 AA.
AC A0A182I9L5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
OS Anopheles arabiensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA010275-PA.1, ECO:0000313|Proteomes:UP000075840};
RN [1] {ECO:0000313|Proteomes:UP000075840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AARA010275-PA.1}
RP IDENTIFICATION.
RC STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA010275-PA.1};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; APCN01001000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A182I9L5; -.
DR EnsemblMetazoa; AARA010275-RA; AARA010275-PA; AARA010275.
DR VEuPathDB; VectorBase:AARA010275; -.
DR VEuPathDB; VectorBase:AARA21_014888; -.
DR Proteomes; UP000075840; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd04033; C2_NEDD4_NEDD4L; 1.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd00201; WW; 3.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR024928; E3_ub_ligase_SMURF1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR11254:SF443; E3 UBIQUITIN-PROTEIN LIGASE NEDD-4; 1.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00397; WW; 3.
DR PIRSF; PIRSF001569; E3_ub_ligase_SMURF1; 3.
DR SMART; SM00239; C2; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00456; WW; 3.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF51045; WW domain; 3.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 3.
DR PROSITE; PS50020; WW_DOMAIN_2; 3.
PE 4: Predicted;
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
SQ SEQUENCE 1021 AA; 113699 MW; 89AB67140DB9EBAA CRC64;
MANVDENGCA GAAPDGQQPL DGAYPLRIKV VAGLQLAKKD IFGASDPYVR IDVNQISGDA
TVLSKFTKTK KRTLHPKWNE EFILRVNPAE HKLVLQVFDE NRLTRDDFLG MVELSLDQLP
KERPGVEIPI RSYPLRPRSA RSNVRGELQL YHAFIVDQDS NETDWEMVDS NPVTSVASTP
RTSTSNAAAF ELPQGWEERQ DANGRTYYVN HVARSTQWER PTAVPMEAIA ESDMDVAFQR
RVHISVDDSA TSDTGSVGSD LAALQLNTSR SNSLVSASNG SLASSARPDG TAEAESTHTV
VLRSGASPAH PAQRHLSTPP RLPAALVRSS TRAVPIPGRA AALNRSRSAV SRWTTVGAAG
QQRMARPGRH EQLTEEPAQT TAEENGENGG VQLRSSAHLT DGGRRSSSRS SIGSDSSLRA
QQRAAIEAAD EDMVDGGGVG QTVVRSGSSH SSSSSSASSN MNGDRRPSTS GGTHPHQHHN
NNNNGGTFGT GATHGSNSIN NNDTSDDRSS TRSSTSNEND SSGSSPSTGG GAGSMTLPAG
WSMQLAPNGR VFFIDHNERK TSWVDPRTGR ASPMPTSQGS AALNDVRRPE DGLAPLPEGW
EERVHSDGRI FFIDHNTRTT QWEDPRLSIP NIAGQAVPYS RDYKRKYEYL KTQLRKPQNV
PNKIEIKVRR ASIMEDSYRI INSVTRLDLL KTKLWIEFEG EAGLDYGGLA REWFYLLSKE
MFNPYYGLFE YSAMDNYTLQ INPYSELCNE DHLLYFRFIG RIAGMAVYHG KLLDAFFIRP
FYKMMLQKPI DLKDMEAVDT EYYNSLVWIK ENDPSELMLT FCVDEDTFGQ TTQHELLPNG
AQIDVTNENK DEYIRLVIQW RFVSRVQVQM QAFLDGFGSL VPLNLLKIFD EHELELLMCG
IQNIDLRDWK RNTLYKGDYY PNHVVIQWFW RAVLSFSNEM RARLLQFVTG TSRVPMNGFK
ELYGSNGPQM FTIEKWGTPE NYPRAHTCFN RLDLPPYESY QQLKDRLIQA VEGSQGFAGV
D
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