ID A0A182IBD8_ANOAR Unreviewed; 2251 AA.
AC A0A182IBD8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 2.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
OS Anopheles arabiensis (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7173 {ECO:0000313|EnsemblMetazoa:AARA010902-PA.2, ECO:0000313|Proteomes:UP000075840};
RN [1] {ECO:0000313|Proteomes:UP000075840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dongola {ECO:0000313|Proteomes:UP000075840};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Howell P., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles arabiensis DONG5_A.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AARA010902-PA.2}
RP IDENTIFICATION.
RC STRAIN=Dongola {ECO:0000313|EnsemblMetazoa:AARA010902-PA.2};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; APCN01000672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EnsemblMetazoa; AARA010902-RA; AARA010902-PA; AARA010902.
DR VEuPathDB; VectorBase:AARA010902; -.
DR VEuPathDB; VectorBase:AARA21_008920; -.
DR OrthoDB; 5482994at2759; -.
DR Proteomes; UP000075840; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd17993; DEXHc_CHD1_2; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR040793; CDH1_2_SANT_HL1.
DR InterPro; IPR025260; CHD1-like_C.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623:SF14; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR Pfam; PF18375; CDH1_2_SANT_HL1; 1.
DR Pfam; PF13907; CHD1-like_C; 1.
DR Pfam; PF00385; Chromo; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01176; DUF4208; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ SEQUENCE 2251 AA; 247888 MW; 43BA0D84450B65DF CRC64;
MSQTKEDKSD SENESSSGGS KSGSSSDSES ESGSGSSSSS SSDNEHDASN NNNGLSRNTS
GTTSTTTHNT STGSSGSDLR NSRTENGLSD SKSSLNRHDE QGEDEEEEEE DDDDRNDSDE
DASMGGGNER VGAGANHHTH THPSAQNSHS RPTARSSSHS GSDSEESGGE DPAHTNGPDG
HNASGVNHHS DSDNSASKPS NTSRQQSDDD DDEEEDDDDE EEDDEDEDEE EEENGTRTAT
PKAEQRLAAG VTAPSVPPPP DEDDDDEEEE DEDEDEEEAQ QSSKSSYDDE DYAANKLRRK
SARKKAVAAA RKRPAAQPTS KAKKKKSSNN RWKSETSESD GSDGDSDDSR EQRHRRKPSG
AAAAAAAAAK KRSTTSNAKS KAAVAAASKK KKSNAYSSDD GSNSDDDRKR SSAATRRKNN
TVSYKEESGD EPTDSDDLLE VDQEAEEAAA ALAAEEEKAE TIERIIGRRR GRRGATGAVT
TVYAIEENGD PNVLGGEGVG REQEEEEEQF LIKWTGWSYL HCTWESEETL REQKVKGMKK
LENYIKREQQ LEYWRKYQAG PEDIDYYECQ QELQQDLLKS YYHVERIIAQ ANKAEEGDSG
LEYLCKWESL PYSDSTWEDA GLIRRKWQQK IVEFHEREES RRTPSKHCKA IRYRPNFKHL
KQQPEYLGEE RGLKLRDYQM DGLNWLILTW CKDNSVILAD EMGLGKTIQT ICFLYYLFKS
QQLYGPFLCV VPLSTMPAWQ REFGIWAPEL NVVTYLGDVQ SREIIRQYEW CYESTKKLKF
NAILTTYEIL LKDKTFLGSI GWASLLVDEA HRLKNDDSLL YKALKEFDTN HRLLITGTPL
QNSLKELWAL LHFIMPERFE SWDDFERNYG NTTNDKSYTK LHKELEPYIL RRVKKDVEKS
LPAKVEQILR VEMTSIQRQY YKWILSKNFD ALRKGMKGSV GTFLNIVIEL KKCCNHAALT
RPIEFETQRN SQQDVVQQLL KGSGKLVLLD KLLCRLKETG HRVLIFSQMV RMLDILAEYL
QKRHFSFQRL DGSIKGELRK QALDHFNAEG STDFCFLLST RAGGLGINLA TADTVIIFDS
DWNPQNDLQA QARAHRIGQK NQVNIYRLVT AHSVEENIVE RAKQKMVLDH LVIQRMDTTG
RTVLDKNGGS NTSNPFNKDE LSAILKFGAE ELFKEEEDGD EELVCDIDEI LRRAETRDEA
PGMPGDELLS AFNVTTFDFD EDKVVSGAKP IGGAPGGGAA DQDQDTKDWD EIIPKSYREL
VEAEERDREI KDLYLPPRRP AVKPGGNSQH GGEPDGRKGG GKAGGKKRKG AADEDSDEAL
DSDGASGAED GKAKRSRGRP SNKEKINGFS DAELRRLIKS YKKFPAPLKR LEAIACDAEL
QEKPLSDLRR VAQLLHDRCL QTMREIAKDA EAEAGGKHHG GGGSAAAAAG ADAKKKCARA
AYSSKIGGAS FNVKTMMQCV EELQPLDEVI PSDAAERARW TLNIKTRPPN FDVDWGGEDD
SRLLRGIYQF GIGSWEAMKM DPSLGLADKI LSNDASRKPQ GKHLQSRAEY LLKVLRKTLE
LKRGPSKPRK QRKPKEMKSA LGGAGMAPVP VVSSPLRDGG DASFSCSISA TIAAVAAGED
VTMGGGVVAG GNGAGGAGAA SLGGGGAVAT GGGAAGGAVV GSTEEKKTGS KIKKLSESDH
HHHHHHHHHH NHHDEHSNGS RAADEHAAVG SSNHAAPAPD KKDKKKSKKD RQKDAKKDKK
NKNTGPMHFT ANNEPCALNI LGDLDPTVFN ECKEKMRPVK KALKTLDNPD ESLSQEEQLR
QTRACLLSIG DQINLCLAEY RDPEKAKEWR SNLWYFVSKF TEFDARKLFK LYKHALKRSE
GSAASGGEAG GGGGGGTTNS TPVKGDGSSG GKGRKGGTKK DNGHGEAGAP PGDSADEGKG
GGSRRDRKEK KRHHHHHSHH PGGGIGGPIM SDSALQQRER YQQQQQSAVG GDNSHHGSDA
VSAGGPKDDS SSTMHSKRRL EEGEYDENSK EYKRLHGDSR SSHRDRDKKW DEYGSERDRM
RNVPPSSRGS APGTPQSMRG AYPDERSPAP YPADGGAWRD HRFGPDHKRD RYDGYGSSRH
SSSSGGYHRD RDRERDRDRD RERDRDRDRD RDRDRDRGDR AYKDKRRYPP PGSGGYSGGH
GYGMSPSGGY YPPGSDSSYR YPMGSGGGGG GGGGYPPSSR PSGTAPPVAV VMPTGAGGGV
VAAPGVVVPP ADYLDYRRSE YDRRPPPAAN N
//
