ID A0A182JSA8_9DIPT Unreviewed; 905 AA.
AC A0A182JSA8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
OS Anopheles christyi.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43041 {ECO:0000313|EnsemblMetazoa:ACHR001390-PA, ECO:0000313|Proteomes:UP000075881};
RN [1] {ECO:0000313|Proteomes:UP000075881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACHKN1017 {ECO:0000313|Proteomes:UP000075881};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles christyi ACHKN1017.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ACHR001390-PA}
RP IDENTIFICATION.
RC STRAIN=ACHKN1017 {ECO:0000313|EnsemblMetazoa:ACHR001390-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A182JSA8; -.
DR STRING; 43041.A0A182JSA8; -.
DR EnsemblMetazoa; ACHR001390-RA; ACHR001390-PA; ACHR001390.
DR VEuPathDB; VectorBase:ACHR001390; -.
DR OrthoDB; 5475408at2759; -.
DR Proteomes; UP000075881; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 5.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24044:SF420; NEUROGENIC LOCUS PROTEIN DELTA; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 4.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF07657; MNNL; 1.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 6.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 7.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 548..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..102
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 167..205
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 207..253
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 255..300
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 384..420
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 422..458
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 460..496
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 511..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 60..69
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 73..85
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 93..102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 195..204
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 243..252
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 259..269
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 290..299
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 410..419
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 448..457
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 486..495
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 905 AA; 96045 MW; 1E322E2FF34C297C CRC64;
GYFTLIIEAW HDTNETTTRS PGTLISRLSI QRILEVSADW MEDSYNSSHT MIRYAFRVTC
DPNYYGAGCA NLCRKRDDQF GHYTCSPIGE RVCLSGWLGE YCTIAQCTPG CLHGHCNKPN
ECICQSGWKG PLCDECEPYP GCLHGTCKKP WECICKEGWG GLFCNQDLNY CTNHKPCLNG
GTCFNTGQGL YTCQCRPGYR GTECELSITS CTDQPCLHGA TCTSTVDGET SMDADGRKYQ
CHCAKGWMGR HCEREAITCS EKPCHQGTCV DVTPSTSSSS STSANFRCDC PPGYSGTACE
IKSGECYSNY CANGGTCHVV GSSSSSSASS ALSSIMSPSS SSSSSSLSAL YGSGNINNNN
NDGGNGMLMC LCPDGFVGDR CEENIDDCVG NLCQNGGTCV DADNHFKCQC VPGFIGTHCE
ETVDLCLTKP CANGGICTNL ENDYRCQCRA GFTGKDCSAD VDECHSAPCR NGGTCINRVN
SYQCVCAGGY RGHSCEEESA AAIQRDTSLE GSEFHHHHHH PQQQQRHSGG EGVDASSRTA
DGLSSGQIVL IAMFSISTPL LAFIATTIVI CLKRKRQREQ EKDDAEARKQ NEQNASHNLS
ASSHHHHHHL QQQQQHQQQQ QQLHHQQSSS SSTSSGALLH PTSQQQQQQY HNGFHNHLQS
SGQKRNSSNT LSNFDSSHHM IKNTWDKSIN NMPSPPTTAS SSGSSGSGSA GTGGCSANGG
GGNVGSAALL LSSANMDDNS CLMASAAAVG NSGVGGTGIG SVGNAANALL YLSTSDDGPT
LASCSTLQRA KSQKQLNTDP SLLLQQQQQH QNHHHNTMLS QTSSSSLHTS ANAASVGGGS
VLSSTVVSST GTPCSNGGGK DMFDKRISVL SESGRLCHPR WNAATSAGVM GGSHSVVGPC
SPPHI
//
