ID   A0A182JV70_9DIPT        Unreviewed;       685 AA.
AC   A0A182JV70;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Xaa-Pro aminopeptidase {ECO:0008006|Google:ProtNLM};
OS   Anopheles christyi.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=43041 {ECO:0000313|EnsemblMetazoa:ACHR002402-PA, ECO:0000313|Proteomes:UP000075881};
RN   [1] {ECO:0000313|Proteomes:UP000075881}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACHKN1017 {ECO:0000313|Proteomes:UP000075881};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles christyi ACHKN1017.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ACHR002402-PA}
RP   IDENTIFICATION.
RC   STRAIN=ACHKN1017 {ECO:0000313|EnsemblMetazoa:ACHR002402-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766}.
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DR   AlphaFoldDB; A0A182JV70; -.
DR   STRING; 43041.A0A182JV70; -.
DR   EnsemblMetazoa; ACHR002402-RA; ACHR002402-PA; ACHR002402.
DR   VEuPathDB; VectorBase:ACHR002402; -.
DR   OrthoDB; 869at2759; -.
DR   Proteomes; UP000075881; Unassembled WGS sequence.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   PANTHER; PTHR43763:SF4; XAA-PRO AMINOPEPTIDASE 2; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE   3: Inferred from homology;
FT   DOMAIN          54..175
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          358..571
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          583..646
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
SQ   SEQUENCE   685 AA;  78064 MW;  B99A63F84F629B6E CRC64;
     MVGQSVANEF QGIRRSKCQQ SRDRTQIYEG VDNVLMKRLQ ALRTEMRTRT STQSAELDAY
     LVPMYDEHQS QYLMESDQRI RFLTGFTGTI GEAVVLLRSA AIWTDDRYIE QADLELNCAW
     RLFRTGERPT VAEYLLSELS PEARVGADPQ LVPHQAWKAV ETELSADYIR MVPITRNLVD
     MVWGGRRPAP RSGAIKVHPV RFAGDRWENK VGRLRANLTA LRCDGMIVTS LTEVAYLLNL
     RGTDIPHVPV FKAYLLVTHR ELLLYTNTSR ETLGLKNHLK AHSCHNENCV QLRDYGDVWR
     DLRTLAQHWH RLLVPGAVVF DTGASEAIHA TLPRNIVFER PSPIIFLRAQ KNPVERQGMR
     QAHVRDGVAM CEVLSRLEER FIAGDHITEM SLAREIDHAR KTQNNSEGIA FPTSVAYGVH
     SSMPNYTPSN RTNIELSEGM VLIDSGGQYE DGTTEVSRTL HLGEPTAEQI RAYTNVLIGM
     IRLSMLTFPE NLKPAELDAL ARGPVWGSMN DYPHGTGHGI GSYSSVRESP ISISYTAKQR
     FTFKEGYFFS NEPGYYKNGA FGIRLENVLE VIDTGKMHPT GYKFLSFQDV TLVPFEWKMI
     DRTLLSVPEK KWLNDYNARI RQHVGSELKR KHKMDAFYWM MNKTRHVPEY VTEAEYNGVA
     RPQHYHLSIA SALTVTFLLT RFVIN
//