ID A0A182JXQ3_9DIPT Unreviewed; 2215 AA.
AC A0A182JXQ3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Laminin subunit alpha {ECO:0008006|Google:ProtNLM};
OS Anopheles christyi.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43041 {ECO:0000313|EnsemblMetazoa:ACHR003285-PA, ECO:0000313|Proteomes:UP000075881};
RN [1] {ECO:0000313|Proteomes:UP000075881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACHKN1017 {ECO:0000313|Proteomes:UP000075881};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles christyi ACHKN1017.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ACHR003285-PA}
RP IDENTIFICATION.
RC STRAIN=ACHKN1017 {ECO:0000313|EnsemblMetazoa:ACHR003285-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR STRING; 43041.A0A182JXQ3; -.
DR EnsemblMetazoa; ACHR003285-RA; ACHR003285-PA; ACHR003285.
DR VEuPathDB; VectorBase:ACHR003285; -.
DR OrthoDB; 90222at2759; -.
DR Proteomes; UP000075881; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00055; EGF_Lam; 7.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 7.
DR Pfam; PF00054; Laminin_G_1; 1.
DR Pfam; PF02210; Laminin_G_2; 3.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00180; EGF_Lam; 8.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00282; LamG; 5.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR PROSITE; PS01248; EGF_LAM_1; 4.
DR PROSITE; PS50027; EGF_LAM_2; 6.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
DR PROSITE; PS51115; LAMININ_IVA; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT DOMAIN 1..49
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 50..97
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 145..190
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 191..246
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 286..478
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 522..568
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 623..670
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1437..1621
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1625..1838
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1850..2026
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2031..2211
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT COILED 708..774
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 978..1005
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 1..13
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 3..20
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 22..31
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 50..62
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 52..69
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 71..80
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 145..157
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 147..164
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 166..175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 217..226
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 541..550
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 623..635
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 625..642
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 644..653
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2184..2211
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 2215 AA; 246579 MW; F6F76A053F2D6E67 CRC64;
CNCHLKGSLG QNCSQKTGQC QCKPNIEGRQ CNLCRKGYWD LNSGNGCIPC ACDSNGSELE
GCDLHTGQCF CKTGVTGTSC DRCDVGFYGF SAQGCKRCDV CSSAAYVCDP DTGRCICPAN
SHGPECRSCI ANTWGNEFQK GCKHCACDIV GSIGQSCERE TGQCSCKEGY TGRQCNECAP
GYYGYPTCHR CACDERGTLP NNNGTVFPCD RNGQCQCKEM VYGKRCDLCR QGTFGLAAFH
PEGCTRCFCF GRASDCTQSD HSWGQVRLAG SRNLSVEYLE RQDGHNEVDY VVILQLEGSQ
MHREDVNITS MNNLELIPSS SGNVSIGAYA TFRYPLYFQL PPQFLGDRTA SYGGQLNFTL
ITAGATINIP EPSLRQFPLV QLHTHENLVL DFYEESIRYG QAVESHSVRL LGSLWRSHYD
GAWVNRTILM TALQNVRHIF VRGSTTMDFQ QVVLTNVTLD TGIFVVGAEN NHAYGVERCS
CSPKYSGLSC QNPGAGYYRH RLPIVDLEWA TIDDMIGKVV PCGCNGRSEE CDPETGVCLN
CRNNTGGEHC ERCAEGFYGD PNLGQCSPCP CPETRKNFAR GCSVRGSEVH CICKPGYTGA
LCDSCMRGYF GHPHLDNGHC DACECNREGS MSDECDHFTG ECHCRPGITG RKCDRCEQPK
HIVQDYRCKI CDNCTITLID DFEILASRLA EDTSHIDRNG IPAPWVELTK YEAKKRQLSD
RVARLLEAED TAKKFMADFA EPLKRNATRL TKRLHKLENR VTNREEEINK CTERANDLFD
EIHVIDGDLR NTIQILKNYG VGDHHIKLPL AIQEAKDLLA DIRDRYEAVQ FDDTVLDCAN
RQFNHWTNVS KTVERQARRL DDLKFEIEQI HHKADHLQNY TVQVFRHVQE TEVYQTANQK
HFDRARGAND KALEYEADVK KLLDTNIMAD TDVTLEMLGD NYDQLEKDNS TLHLFVEGLN
DSTEDLIRKK SILLETQIPK AIRHAEQLKA KADQIKNKFQ TTEDISAKAM KASQAYENII
SSIVAAQSSA DNATSTVEKA DQLIHPLHDV TISDQSHKAL GVSTNLTSRA NKELNKAVAL
NETMIQKEKS VQSLKDQIWQ TAIKNNNLMD ELGKVERGET MKTVQSDLDR SSIVSEQMKF
VRQDAINLNS DVYKLKLKLK SLEPEWDTKF GMAEENVSQT FGNIRKAKDK LNGIEALAKI
QEDRYKAWNQ SFAGQLQQLR DQIALAKHAA EGIRVSMESA DQCIRSYAPA TFGPSTTNRI
VMSIALTNPN VQNSPLAYIE GDDRRFIALE LRQRKIRMLW SLDGGTVTTM THPQEIEVRD
LKNDAAWYFI DATRTFNVGT LNVRHMLPAG VLNNARPIAG ASSPAYTTIN IGPSSRIWVG
GIPDDLRVPE LEPSQGLGVA VSQLYVDQRQ LGLWHFTSSS GKCAGAMLGP QEVASSTNER
NFNGNGYAVL QHTGRLNKVE FSLSLSFKTL DEDALIFLAL DEKNNRSVSL TLYQGRLVFR
VDYGDDARLE INTTKRYNTG RWVVVEASRQ YRKSRTDEGV LKVDGLDNIL GSPTKPIGAS
MLPVLSDKYY LGGVPPGFKT GTTKAPGADH AFLGCVKGLQ ISGTSYDPLD STTHFGIETS
CDSTIVKAGF FGEGYVEFPS FPLKKRANFG FVFRTMQPDA LLLLSAYPSR IHDDYDAKDT
FGNYSVFLSE GRLHLWMDAG TGRIELISNG TLNDGEYHVL AVVKQGRHVE LRIDDKLQMS
RTLQSSLVNM PGESGGLYIG GVPYDPAFAS LAKVFDGLKG VVANVVFNNQ TLSFGQALNF
TDVQMGRTGP PMGSQGLYTA LMKTEPIGRS FKAAPEGCHR VGSYSYEPNA FKYGDKPQSY
SVVTVQARNM WQRNFHIEFD FRTYYPNGIL FVALGTKEKA KHFIMLALKD GFLKLTVRGR
KRDQLLLPPK LNDGQWYRVS LSSVKKKAKL SVQMGGGHSS AQLKLPKKLN AANTLHVGGL
PDEVPILPRE LQPRPEAFKG CLRKFVVNNN TQDLARPGRH LHVGQCFPRI ERGSYFPGDA
YAIYKRNFNV GKFMEIELEV RTSEMNGILM SVADQINGFP ALSLEISNGN ILLSVDNGDG
NPTRLSTSLP SKYTLCDNRW HNISALYEDH QMALRVNEFP PSLLLPHGTT GFGRVNTKAP
LYIGGLPDAA SSGTLLMREN FKGCIRNIVI RNERKDWTDM DDLHNVLLSE CLAVN
//
