ID A0A182JYR7_9DIPT Unreviewed; 1366 AA.
AC A0A182JYR7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Major facilitator superfamily associated domain-containing protein {ECO:0000259|Pfam:PF12832};
OS Anopheles christyi.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43041 {ECO:0000313|EnsemblMetazoa:ACHR003649-PA, ECO:0000313|Proteomes:UP000075881};
RN [1] {ECO:0000313|Proteomes:UP000075881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACHKN1017 {ECO:0000313|Proteomes:UP000075881};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles christyi ACHKN1017.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ACHR003649-PA}
RP IDENTIFICATION.
RC STRAIN=ACHKN1017 {ECO:0000313|EnsemblMetazoa:ACHR003649-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC {ECO:0000256|ARBA:ARBA00005241}.
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DR STRING; 43041.A0A182JYR7; -.
DR EnsemblMetazoa; ACHR003649-RA; ACHR003649-PA; ACHR003649.
DR VEuPathDB; VectorBase:ACHR003649; -.
DR OrthoDB; 1937075at2759; -.
DR Proteomes; UP000075881; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17352; MFS_MCT_SLC16; 1.
DR CDD; cd17335; MFS_MFSD6; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 5.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR024989; MFS_assoc_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR16172:SF2; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6; 1.
DR PANTHER; PTHR16172; UNCHARACTERIZED; 1.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF12832; MFS_1_like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 61..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 501..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..679
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 730..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 790..808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 913..942
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 954..971
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 991..1009
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1102..1122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1134..1152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1164..1181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1257..1275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 727..1256
FT /note="Major facilitator superfamily associated"
FT /evidence="ECO:0000259|Pfam:PF12832"
FT REGION 311..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1339..1366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1366 AA; 149196 MW; A5347156E81D404D CRC64;
MIVFFCPLQM PPQNSIELTT KPEAENGATG KLLAANGNGD TVKAKEDPPT TTLIVPPDGG
WGWLVMIASF FCNVIVDGIV MNVGSFLGPI RDEFGVSEAE VALVSSLLSG FYLLTGPFVS
ALANRWGFRI VTIIGALVAS LGFFVSQYAT SIVFLYVTFG FIGGVGFCFI YVPSVITVGY
YFEKWRAVAT GIALCGSGVG TFIFSPVNAM LIESLGWRSA LVAQAAIILL CIACGAIFRP
IQPTEVTATK TDDTPADKGI LLGEGLPVVY TRPLPEGRYA YSMPNSSHNT WMGTNPNYQY
PTAAEIFRQG SGHNLDRRPS HTSGQLVSHN LQSTTKKLEK IQKRLAGQMT PDDTIHAHGY
PTAHHELNPV GEADEEETEN GTLLTAPEQQ SATITTAAGR RHTVSGRRPN EPASSRHGSR
RTLNDGARPM YRDDIFFTGS LARIPQYKSQ TSLGYHMSVT RLPTQADVEE TETEQCMVCP
EAVRRTLVTM LDMSLLKSPS FMMLAFSGFL TMMGFFVPFL YVKQRAVAGG MADEVSTFIV
SAIGISNTIA RVVCGVLTSF KNINALHLNN VAITLGGIAT MISGIYITEA YQFTYAGVFG
LAIACFSALR SILVVDLMGL EKLTNAFGIL CLFQGIAAFL GAPIAGYFTE LTGSYDASFY
ISGALITLSA ILCYPLAFVN RWEKQRAAKK DSQKVYPQAK ESTHKIRGKS DILEMLFGSV
DQELLPVKTF YFFFYSAFGS LFPLMGVYFK QMGMNPGQCG LLIGTRPFVE FLSAPFWGSY
ADRCKKGKML LLASLAAWII FTLPLGFIQP PATSCIERKN ATDFELRTPQ VPRILKRSID
ESMLEEISFG KYATDSDSSF TRVERAARPV AAAGVSPLDV SYANNFNEKL HRDWVSPLFS
SIVYRTADIQ KAFFLLLLLV IIGEFFSAPA ITLADSAVIT ILGEDADRYG HQRMFGSLGW
GLAMFFVGIA LDHSTAFPDH PCGPEKQEKN YTICFATFSV LMGAALISAT QIQFKYDYSE
PQEPIQVEKV PQELTHEEQM QAQLAQQLQL PSLAATGTGM TSAAPPAAAL GAQTKMFAQT
TREMPEWVTV LKQFKNLKCA SFLFVAWFMG FGIGLIFTFL FWHLQDYGGS PTLFGVASVI
NHISEIFAYF FSFKLITQIG HVKVLCLGLV GNILRFLYIS YLKNPWWVLP FEFMQGITHA
AVWAACCSYI AHNTPQHLRS SAQGVLQGLH HGLGRGCGAV IGGMFVTYFG TTATFRGYGV
ICILVLAAFV FINFYRKDEG FISEIPTTED PHQVAEETAH LAPHGVPSNP IPRALSSTRL
NEIGQQNVDN GYGTYQTTGG ALDVPGGAPK NPFGAPQGNV YGGNQY
//
