ID A0A182K0S4_9DIPT Unreviewed; 970 AA.
AC A0A182K0S4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
OS Anopheles christyi.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43041 {ECO:0000313|EnsemblMetazoa:ACHR004356-PA, ECO:0000313|Proteomes:UP000075881};
RN [1] {ECO:0000313|Proteomes:UP000075881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACHKN1017 {ECO:0000313|Proteomes:UP000075881};
RG The Broad Institute Genomics Platform;
RA Neafsey D.E., Besansky N., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Anopheles christyi ACHKN1017.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ACHR004356-PA}
RP IDENTIFICATION.
RC STRAIN=ACHKN1017 {ECO:0000313|EnsemblMetazoa:ACHR004356-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A182K0S4; -.
DR STRING; 43041.A0A182K0S4; -.
DR EnsemblMetazoa; ACHR004356-RA; ACHR004356-PA; ACHR004356.
DR VEuPathDB; VectorBase:ACHR004356; -.
DR OrthoDB; 1194at2759; -.
DR Proteomes; UP000075881; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd03683; ClC_1_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 2.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR PANTHER; PTHR45720:SF10; CHLORIDE CHANNEL PROTEIN 2; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 56..73
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 99..121
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 204..228
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 240..261
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 286..308
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 329..348
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 394..413
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 425..444
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 464..485
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 497..516
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 547..607
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 623..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 945..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 970 AA; 107306 MW; C5E45F7C085B3976 CRC64;
MKREDSGFLN DEEKKMIKQE TRWKSLQELL DVRDNKFFKA ASWLWRNTFA RLGEDWVFLA
MLGIIMALLS YVMDKGISMC TNSRVWLYRD LTNHPVAQYL AWVSLPVCLI LFSAGFVHLV
APQSIGSGIP EMKTILRGVA LKEYLTFKTL VAKVIGLTAT LGSGMPLGKE GPFVHIASIV
SQLLSKIITS FQSIYENESR NTEMLAAACA VGVGACFAAP IGGVLFSIEV TTTYFAVRNY
WRGFFAAVCG ATVFRLLAVW FQKADTVTAM FSTNFTSDFP FDPQELFVFA LIGLVCGLGG
ALYVWVHRKY VLFMRSNKKM NKFLQKNRFL YPGIVALIVA TLSFPLGFGK YIAGELSTHD
QVHQLFSNFT WTKHELTVEQ AAVVSNWRTP ETNVFANLII YLLYTFFMSI IASTIPVPSG
MFIPVFKIGA AFGRIVGEAM HLWFPHGVRY GGMLAPIIPG GYSVVGAAAF SGAVTHTVSV
GVIVFEMTGQ ITHIVPVMIA ALISNAVAAL LQPSMYDSII LIKKLPYLPD LLPSGSGMYN
IYVEDFMVRD VRYIWKGISY QQLKEILKAN KGLRSLPIVD SPDNKTLLGS VQRYELIKMI
DKHIGREKRL EVAAKLMKEA EEKAREEQER QKREAAEAQK ARRPSRFEVV PAPDILKLRE
RANNEMLPPQ ARRESNASLT SGPVFGGTQP KKSILKKTNS FTLKGFSPLS PHSPVHTPYT
TITGTESRIR SAFDIIFRKS ATLQDVTPDP EIGSIGTPSI VGSEVAPLTP GISKKVQLPR
ERVIDMSPED QKAWEMEEMA KSIDVANLHI DPAPFQLVER TSILKVHSLF SMVGINHAYV
TNVGQLVGVV ALKELRTAIE SVNNGTLTPE SVKAKQEEEA RALAQKESDN NNGISAEDPL
LPKRPGDTFS DKKVNNTITS MDSALSNSDN CSDIELDNIN IDHGDTAATT NGTTTTTTKH
TNNHSGSQQQ
//
