ID   A0A182K378_9DIPT        Unreviewed;      1238 AA.
AC   A0A182K378;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=TATA-binding protein interacting (TIP20) domain-containing protein {ECO:0000259|Pfam:PF08623};
OS   Anopheles christyi.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=43041 {ECO:0000313|EnsemblMetazoa:ACHR005213-PA, ECO:0000313|Proteomes:UP000075881};
RN   [1] {ECO:0000313|Proteomes:UP000075881}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACHKN1017 {ECO:0000313|Proteomes:UP000075881};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles christyi ACHKN1017.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ACHR005213-PA}
RP   IDENTIFICATION.
RC   STRAIN=ACHKN1017 {ECO:0000313|EnsemblMetazoa:ACHR005213-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CAND family.
CC       {ECO:0000256|ARBA:ARBA00007657}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A182K378; -.
DR   STRING; 43041.A0A182K378; -.
DR   EnsemblMetazoa; ACHR005213-RA; ACHR005213-PA; ACHR005213.
DR   VEuPathDB; VectorBase:ACHR005213; -.
DR   OrthoDB; 68829at2759; -.
DR   Proteomes; UP000075881; Unassembled WGS sequence.
DR   GO; GO:0010265; P:SCF complex assembly; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039852; CAND1/CAND2.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR013932; TATA-bd_TIP120.
DR   PANTHER; PTHR12696:SF0; CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 1; 1.
DR   PANTHER; PTHR12696; TIP120; 1.
DR   Pfam; PF08623; TIP120; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   3: Inferred from homology;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REPEAT          47..84
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   DOMAIN          1041..1194
FT                   /note="TATA-binding protein interacting (TIP20)"
FT                   /evidence="ECO:0000259|Pfam:PF08623"
FT   REGION          311..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        315..335
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1238 AA;  138815 MW;  887AEF0C0FF90E78 CRC64;
     MASYQIANLL EKMTSNDKDF RFMATNDLMT ELQKDSIKLD DESEKKVVRM VLRLLEDKNG
     EVQNLAVKCL GPLVNKVKEN QVETIVDLLC ANMVSNNEQL RDISSIGLKT VISELPQSSN
     SLVPNVCQRI TGKLSVAIEK EDVSVQLEAL DILSDLLSRF GDLLVPFHEL ILKALVPQLG
     SARQAVRKRT IVALSHLLTT CNNNAYNKVI EHLLDGLEKP QNPGTIRTYI QCLAAICRQA
     GHRLCNHIER VMFLLNQYSL RDDDELREFC LQACEAFVQR CPEAIMPHIP TIVDLCLKYI
     TYDPNYNYEA DDGEGGTSME MEDDEEIDSE EYSDDDDMSW KVRRSAAKCL ESVISTRHEL
     LEEFYKTLSP ALIARFKERE ENVKSDIFHA YIALLKSTRP MGDDIGHDPD SMEQIPGPIS
     MLTDQVPTIV KAVQPLMREK SVKTRQDCFL LLRELLNALP GALSNHIDQL MSGIHYSLND
     KNSTSNMKID ALGFVYCMLV GHNPQVFHSH IQLLVPLVVN AVFDPFYKIA TEALLVLQQL
     VKVIRPVDVQ TTFDFTPYVS QLYTSTLQKL RSPEVDQEVK ERAIACMGQI IANMGDVLQP
     ELVTCLPLFM ERLRNEVTRL SSVKALTMIA ASPLRVNLSP IIGEVIPVLG SFLRKNQRAL
     KLNSLTLLDT LVTHYSQFLD PKLLRGAVGE VPPLLSESDL HVAQLSLVLL TSVARQQPEA
     LVGVHEQILQ EVMTLVRSPL LQGTALNCTL KLFQALVQAQ LPGLSYRHLL GMLMNPVYNQ
     QQQGGSPLHK QAYHSLAKCI AALTLQVPNE ALTVAGEFLR EIQNRRNDSH LMFYLLTIGE
     IGRHFNLHTI DTLAQTILNC FSASSEDVKG AASHALGAIA VGNLNHYLPF ILNEIEAQPK
     RQYLLLHSLK EVISSLSTSK AGLEQLLPSV PSIWTQLFKH CECSEEGSRN VVAECLGKLV
     LVNPEELLPR LQMALQSESA LMRTAVVSAI KFTISDQPQP IDPLLRQCIG QFLFALQDPE
     PSVRRVALVA FNSAVHNKPS LVRDLLPELL PQLYSETKVK KELIREVEMG PFKHTVDDGL
     DIRKAAFECM YTLLEQGLDR VDIMQFLEHV QAGLRDHYDI KMLTYLMTAR LAALCPNAVL
     QKLDQFVEPL RATCTLKVKA NSVKQEYEKQ DELKRSALRA VAALLQIPKA DKNIYLAEFL
     ILIRSSSELQ PLLESVQKDS SGQLNNNIDG RDLSMDQS
//