ID   A0A182K5H4_9DIPT        Unreviewed;       557 AA.
AC   A0A182K5H4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Major facilitator superfamily associated domain-containing protein {ECO:0000259|Pfam:PF12832};
OS   Anopheles christyi.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=43041 {ECO:0000313|EnsemblMetazoa:ACHR006009-PA, ECO:0000313|Proteomes:UP000075881};
RN   [1] {ECO:0000313|Proteomes:UP000075881}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACHKN1017 {ECO:0000313|Proteomes:UP000075881};
RG   The Broad Institute Genomics Platform;
RA   Neafsey D.E., Besansky N., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Anopheles christyi ACHKN1017.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:ACHR006009-PA}
RP   IDENTIFICATION.
RC   STRAIN=ACHKN1017 {ECO:0000313|EnsemblMetazoa:ACHR006009-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC       {ECO:0000256|ARBA:ARBA00005241}.
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DR   AlphaFoldDB; A0A182K5H4; -.
DR   STRING; 43041.A0A182K5H4; -.
DR   EnsemblMetazoa; ACHR006009-RA; ACHR006009-PA; ACHR006009.
DR   VEuPathDB; VectorBase:ACHR006009; -.
DR   OrthoDB; 2905618at2759; -.
DR   Proteomes; UP000075881; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR   InterPro; IPR024989; MFS_assoc_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR16172:SF38; GH27779P; 1.
DR   PANTHER; PTHR16172; UNCHARACTERIZED; 1.
DR   Pfam; PF12832; MFS_1_like; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        53..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        237..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        313..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        378..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        416..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        446..465
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        471..491
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          19..470
FT                   /note="Major facilitator superfamily associated"
FT                   /evidence="ECO:0000259|Pfam:PF12832"
SQ   SEQUENCE   557 AA;  61206 MW;  FCCAB693516A4BC5 CRC64;
     MDTKEKNLPS TRWFNPKLLQ LKVTLFLLFG ATSALTPYLT IHMQSIGLTV EEVASVYLTL
     LFTSCLSPPL TGYLIDRFGR YKPVLLTSIV LNAVSHHLIH FIPARDATAT QHRSWNVSLA
     DDSSALFINA VICPNEVYLN ATCTSNATTS LPTYLTTSDT RCGNLIIPEC AFSELSTGSL
     TLVERIPLIT EYDETFWTYL AVRFVAASML ASTLTITDPI ALDMVEQYGG DFGREKLYSS
     VGMAIFTPLT GLMIDACSSG SGPTETVYTP AFYTYDLLLL GSLVSVSLMP IGRKVPSDSV
     MKDTRRILRL PPVLAFLAFL FLLGNFWGFI ESYLFVIMKS MGSPNYLLGL TYTVGTVASI
     PMMYLLERIT QRVGHVNLLA IAFFAHALRI LGYSWITNPF WCFPIELNEA ISCYFMWVVA
     TTYCAVLAPN NLVATLIGIA GMVHFCLGKG VGAFVGGFLI ARVGLTLAFR YVGYLAIGCG
     VLYKLVHLLW LHKYDGRSQS SPEPGHPAVA ELVKRRASIL PKVDQFGSVV SFGGLTRTKM
     DDARGCTVEE QAPLEKG
//